PT1018512E - Novos derivados basicos de benzo¬e|isoindol-1-onas e pirrolo¬3,4-c|quinolin-1-onas com actividade antagonista de 5ht3 a sua preparacao e o seu uso terapeutico - Google Patents
Novos derivados basicos de benzo¬e|isoindol-1-onas e pirrolo¬3,4-c|quinolin-1-onas com actividade antagonista de 5ht3 a sua preparacao e o seu uso terapeuticoInfo
- Publication number
- PT1018512E PT1018512E PT99120342T PT99120342T PT1018512E PT 1018512 E PT1018512 E PT 1018512E PT 99120342 T PT99120342 T PT 99120342T PT 99120342 T PT99120342 T PT 99120342T PT 1018512 E PT1018512 E PT 1018512E
- Authority
- PT
- Portugal
- Prior art keywords
- onas
- group
- derivatives
- novel
- methoxyphenol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998TO000871A IT1303123B1 (it) | 1998-10-13 | 1998-10-13 | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1018512E true PT1018512E (pt) | 2004-08-31 |
Family
ID=11417108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99120342T PT1018512E (pt) | 1998-10-13 | 1999-10-12 | Novos derivados basicos de benzo¬e|isoindol-1-onas e pirrolo¬3,4-c|quinolin-1-onas com actividade antagonista de 5ht3 a sua preparacao e o seu uso terapeutico |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6323216B1 (pt) |
| EP (1) | EP1018512B1 (pt) |
| JP (1) | JP2000119270A (pt) |
| AT (1) | ATE269329T1 (pt) |
| AU (1) | AU754739B2 (pt) |
| CA (1) | CA2285817C (pt) |
| DE (1) | DE69918046T2 (pt) |
| ES (1) | ES2218930T3 (pt) |
| IT (1) | IT1303123B1 (pt) |
| PT (1) | PT1018512E (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004506686A (ja) * | 2000-08-21 | 2004-03-04 | ジョージタウン ユニバーシティ | モノアミン輸送体のモジュレーターとしての２，３−二置換キヌクリジン、及びこれに基づく治療及び診断法 |
| CA2523077A1 (en) * | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
| SE0400970D0 (sv) * | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| PT2326645E (pt) | 2008-07-29 | 2012-12-27 | Acraf | Composto com atividade serotoninérgica, processo para a sua preparação e composição farmacêutica que o compreende |
| CA2787063C (en) * | 2010-01-11 | 2018-11-27 | Astraea Therapeutics, Llc | Nicotinic acetylcholine receptor modulators |
| CN113302175A (zh) * | 2018-11-09 | 2021-08-24 | 维瓦斯治疗公司 | 双环化合物 |
| WO2020214734A1 (en) | 2019-04-16 | 2020-10-22 | Vivace Therapeutics, Inc. | Bicyclic compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200413A (en) | 1987-01-05 | 1993-04-06 | Beecham Group P.L.C. | Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis |
| GB9009542D0 (en) * | 1990-04-27 | 1990-06-20 | Beecham Group Plc | Novel compounds |
| US5189041A (en) * | 1990-11-16 | 1993-02-23 | Syntex (U.S.A.) Inc. | Tricyclic 5-ht3 receptor antagonists |
| AU1161292A (en) * | 1991-01-09 | 1992-08-17 | Smithkline Beecham Plc | Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
| US5260303A (en) | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
| US5280028A (en) | 1992-06-24 | 1994-01-18 | G. D. Searle & Co. | Benzimidazole compounds |
| IT1265057B1 (it) | 1993-08-05 | 1996-10-28 | Dompe Spa | Tropil 7-azaindolil-3-carbossiamidi |
| WO1995009168A1 (fr) | 1993-09-30 | 1995-04-06 | Tokyo Tanabe Company Limited | Compose d'indoline et antagoniste des recepteurs de 5-ht3 contenant ce compose comme principe actif |
| FR2710915B1 (fr) | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique. |
| EP0647639A1 (fr) | 1993-10-11 | 1995-04-12 | Sanofi | Hétéroarylpipéridines, procédé pour leur préparation et compositions pharmaceutiques les contenant |
| US5399562A (en) | 1994-02-04 | 1995-03-21 | G. D. Searle & Co. | Indolones useful as serotonergic agents |
| GB9410441D0 (en) * | 1994-05-25 | 1994-07-13 | Erba Carlo Spa | Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation |
-
1998
- 1998-10-13 IT IT1998TO000871A patent/IT1303123B1/it active IP Right Grant
-
1999
- 1999-10-12 PT PT99120342T patent/PT1018512E/pt unknown
- 1999-10-12 ES ES99120342T patent/ES2218930T3/es not_active Expired - Lifetime
- 1999-10-12 EP EP99120342A patent/EP1018512B1/en not_active Expired - Lifetime
- 1999-10-12 DE DE69918046T patent/DE69918046T2/de not_active Expired - Fee Related
- 1999-10-12 AU AU53597/99A patent/AU754739B2/en not_active Ceased
- 1999-10-12 AT AT99120342T patent/ATE269329T1/de not_active IP Right Cessation
- 1999-10-12 JP JP11289461A patent/JP2000119270A/ja active Pending
- 1999-10-12 CA CA002285817A patent/CA2285817C/en not_active Expired - Fee Related
- 1999-10-13 US US09/417,098 patent/US6323216B1/en not_active Expired - Fee Related
-
2001
- 2001-10-02 US US09/967,972 patent/US6413978B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2218930T3 (es) | 2004-11-16 |
| CA2285817C (en) | 2008-12-16 |
| DE69918046D1 (de) | 2004-07-22 |
| IT1303123B1 (it) | 2000-10-30 |
| EP1018512A1 (en) | 2000-07-12 |
| DE69918046T2 (de) | 2005-07-14 |
| CA2285817A1 (en) | 2000-04-13 |
| EP1018512B1 (en) | 2004-06-16 |
| AU5359799A (en) | 2000-04-20 |
| AU754739B2 (en) | 2002-11-21 |
| US20020042426A1 (en) | 2002-04-11 |
| US6323216B1 (en) | 2001-11-27 |
| US6413978B1 (en) | 2002-07-02 |
| ATE269329T1 (de) | 2004-07-15 |
| ITTO980871A1 (it) | 2000-04-13 |
| JP2000119270A (ja) | 2000-04-25 |
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