ES2060655T3 - Derivados de lactamas. - Google Patents

Derivados de lactamas.

Info

Publication number
ES2060655T3
ES2060655T3 ES88308135T ES88308135T ES2060655T3 ES 2060655 T3 ES2060655 T3 ES 2060655T3 ES 88308135 T ES88308135 T ES 88308135T ES 88308135 T ES88308135 T ES 88308135T ES 2060655 T3 ES2060655 T3 ES 2060655T3
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
6alkyl
phenyl
phenylc1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88308135T
Other languages
English (en)
Inventor
Ian Harold Coates
Peter Charles North
Alexander William Oxford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878720695A external-priority patent/GB8720695D0/en
Priority claimed from GB888819382A external-priority patent/GB8819382D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2060655T3 publication Critical patent/ES2060655T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

LA INVENCION SE REFIERE A LAS LACTONAS TRICICLICAS CON FORMULA(I) DONDE IM ES UN GRUPO IMIDAZAZIL DE FORMULA(II) O (III) Y R1 ES UN ATOMO DE HIDROGENO O UN GRUPO C1-6 ALQUILO, C3-6 ALQUENILO, C3-10 ALQUINILO, C3-7 CICLOALQUILO, C3-7 CICLOALQUIL C1-4 ALQUILO, FENILO, FENIL C1-3 ALQUILO, FENILMETOXIMETILO, FENOXIETILO, FENOXIMETILO, - CO2R5, - COR5, CONR5R6, O - SO2R5 (DONDE R5 Y R6 PUEDEN SER IGUALES O DIFERENTES, Y PUEDEN SER UN ATOMO DE HIDROGENO, UN ALQUILO C1-6 O UN GRUPO CICLOALQUILO C3-7 O UN GRUPO FENILO O FENIL C1-4 ALQUILO, EN DONDE EL GRUPO FENILO PUEDE OPCIONALMENTE ESTAR SUSTITUIDO EN UNA O MAS POSICIONES POR GRUPOS C1-4 ALQUILO, C1-4 ALCOXI O HIDROXI O POR ATOMOS HALOGENOS, CON LA SALVEDAD DE QUE R5 NO PUEDE SER UN ATOMO DE HIDROGENO CUANDO R1 ES UN GRUPO - CO2R5 O - SO2R5); UNO DE LOS GRUPOS REPRESENTADOS POR R2, R3 Y R4 ES UN ATOMO DE HIDROGENO O UN GRUPO C1-6 ALQUILO, C3-7 CICLOALQUILO, C3-6 ALQUENILO, FENILO O FENIL C1-3 ALQUILO, Y CADA UNO DE LOS OTROS DOS GRUPOS, QUE PUEDEN SER IGUALES ENTRE SI O DIFERENTES REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO C1-6 ALQUILO; N TIENE UN VALOR DE 2 O 3; TAMBIEN SE REFIEREN LAS SALES Y SOLVATOS DERIVADOS QUE SON FISIOLOGICAMENTE ADMISIBLES. ESTOS COMPUESTOS SON POTENTES ANTAGONISTAS SELECTIVOS DE LOS EFECTOS DE LOS RECEPTORES DE 5 HT Y 5 - HT3, Y SON UTILES, P.E., EN EL TRATAMIENTO DE TRANSTORNOS PSICOTICOS, ANSIEDAD, NAUSEAS Y VOMITOS.
ES88308135T 1987-09-03 1988-09-02 Derivados de lactamas. Expired - Lifetime ES2060655T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878720695A GB8720695D0 (en) 1987-09-03 1987-09-03 Chemical compounds
GB888819382A GB8819382D0 (en) 1988-08-15 1988-08-15 Lactame derivatives

Publications (1)

Publication Number Publication Date
ES2060655T3 true ES2060655T3 (es) 1994-12-01

Family

ID=26292675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88308135T Expired - Lifetime ES2060655T3 (es) 1987-09-03 1988-09-02 Derivados de lactamas.

Country Status (15)

Country Link
EP (1) EP0306323B1 (es)
AT (1) ATE111910T1 (es)
AU (1) AU613662B2 (es)
CY (1) CY1789A (es)
CZ (1) CZ404491A3 (es)
DE (1) DE3851597T2 (es)
ES (1) ES2060655T3 (es)
GB (1) GB2209335B (es)
HK (1) HK75591A (es)
HU (1) HU211843A9 (es)
IE (1) IE61669B1 (es)
IL (1) IL87658A (es)
NZ (1) NZ226032A (es)
PH (1) PH25493A (es)
SK (1) SK404491A3 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
NZ230154A (en) * 1988-08-02 1991-10-25 Glaxo Group Ltd Imidazolyl-substituted 6- or 7-membered ring lactam derivatives and pharmaceutical composition
HU207078B (en) * 1988-08-02 1993-03-01 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
JPH02167280A (ja) * 1988-08-15 1990-06-27 Glaxo Group Ltd ラクタム誘導体
GB8820650D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
JPH02180885A (ja) * 1988-09-01 1990-07-13 Glaxo Group Ltd ラクタム誘導体
GB8820651D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
GB8820653D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
GB8904552D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical process
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
NZ233285A (en) * 1989-04-18 1992-06-25 Duphar Int Res Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions
US5530008A (en) * 1989-04-21 1996-06-25 Sandoz Ltd. Use of 5-HT3 receptor antagonists in treating panic disorders or obsessive compulsive disorders
CA2031214A1 (en) 1989-04-21 1990-10-22 Alberto Azcona Therapeutic use of 5-ht receptor antagonists
GB8913646D0 (en) * 1989-06-14 1989-08-02 Glaxo Group Ltd Chemical compounds
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5180728A (en) * 1989-09-25 1993-01-19 Fujisawa Pharmaceutical Company, Ltd. Pyrimidoindole derivatives and processes for preparation thereof
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
GB9011469D0 (en) * 1990-05-23 1990-07-11 Glaxo Group Ltd Chemical process
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
GB9721139D0 (en) 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
CA2399791A1 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
WO2003061657A1 (en) 2002-01-18 2003-07-31 Aryx Therapeutics 5-ht3 receptor antagonists and methods of use
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
WO2010133663A1 (en) 2009-05-20 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0191562B1 (en) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolone derivatives
NZ230154A (en) * 1988-08-02 1991-10-25 Glaxo Group Ltd Imidazolyl-substituted 6- or 7-membered ring lactam derivatives and pharmaceutical composition
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same

Also Published As

Publication number Publication date
ATE111910T1 (de) 1994-10-15
IE61669B1 (en) 1994-11-16
PH25493A (en) 1991-07-24
NZ226032A (en) 1991-12-23
CY1789A (en) 1995-10-20
AU613662B2 (en) 1991-08-08
EP0306323B1 (en) 1994-09-21
AU2174288A (en) 1989-03-09
DE3851597D1 (de) 1994-10-27
CZ404491A3 (en) 1993-04-14
EP0306323A3 (en) 1990-07-18
EP0306323A2 (en) 1989-03-08
GB2209335A (en) 1989-05-10
IL87658A (en) 1994-06-24
SK404491A3 (en) 2000-12-11
GB2209335B (en) 1991-05-29
DE3851597T2 (de) 1995-01-26
HK75591A (en) 1991-10-04
IL87658A0 (en) 1989-02-28
IE882669L (en) 1989-03-03
HU211843A9 (en) 1995-12-28
GB8820736D0 (en) 1988-10-05

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