ES2088389T3 - Derivados de lactamas. - Google Patents

Derivados de lactamas.

Info

Publication number
ES2088389T3
ES2088389T3 ES89307788T ES89307788T ES2088389T3 ES 2088389 T3 ES2088389 T3 ES 2088389T3 ES 89307788 T ES89307788 T ES 89307788T ES 89307788 T ES89307788 T ES 89307788T ES 2088389 T3 ES2088389 T3 ES 2088389T3
Authority
ES
Spain
Prior art keywords
group
4alkyl
hydrogen atom
6alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89307788T
Other languages
English (en)
Inventor
Ian Harold Coates
Alexander William Oxford
Peter Charles North
Barry John Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888818393A external-priority patent/GB8818393D0/en
Priority claimed from GB898904195A external-priority patent/GB8904195D0/en
Priority claimed from GB898904550A external-priority patent/GB8904550D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority claimed from HU90608A external-priority patent/HU207078B/hu
Application granted granted Critical
Publication of ES2088389T3 publication Critical patent/ES2088389T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LACTAMAS TRICICLICAS, DE FORMUA GENERAL (I), DONDE IM ES UN GRUPO IMIDAZOL DE FORMULA: (FIG. A) O (FIG. B), Y R1 ES UN ATOMO DE HIDROGENO O UN GRUPO ELEGIDO DE ALQUILO C1-C6, ALQUENILO C3-C6, ALQUINILO C3-C10, CICLOALQUILO C3-C7, CICLOALQUIL C3-C7 ALQUILO C1-C4, FENILO, FENILALQUILO C1-C3, -CO2R5, -COR5, -CONR5R6 O -SO2R5, DONDE R5 Y R6, QUE PUEDEN SER EL MISMO O DIFERENTES, REPRESENTAN CADA UNO UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO C1-C6 O CICLOALQUILO C3-C7, O UN GRUPO FENILO O FENIL ALQUILO C1-C4, EN EL QUE EL GRUPO FENILO ESTA OPCIONALMENTE SUSTITUIDO POR UNO O MAS GRUPOS ALQUILO C1-C4, ALCOXI C1-C4 O HIDROXI; O ATOMOS DE HALOGENO, CON LA CONDICION DE QUE R5 NO REPRESENTA UN ATONO DE HIDROGENO CUANDO R1 ES UN GRUPO ALQUILO -CO2R5 O -SO2R5, UNO DE LOS GRUPOS REPRESENTADOS POR R2, R3 Y R4 ES HIDROGENO O UN GRUPO ALQUILO C1-C6, CICLOALQUILO C3-C7, ALQUENILO C3-C6, FENILO O FENILALQUILO C1-C3, Y CADA UNO DE LOS OTROS DOS GRUPOS, QUE PUEDEN SER EL MISMO O DIFERENTES, SON UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-C6; Y ES EL GRUPO CH=CH O (CH2)N, DONDE N ES 2 O 3, Q ES UN ATOMO DE HALOGENO O UN GRUPO ELEGIDO DE HIDROXI, ALCOXI C1-C4, FENILALCOXI C1-C4, ALQUILO C1-C6, CIANO, FENILO, QUE PUEDE ESTAR SIN SUSTITUIR O SUSTITUIDO POR UNO O MAS ALQUILO C1-C4, ALCOXI C1-C4 O HIDROXI O ATOMOS DE HALOGENO, O -NR7R8, CONR7R8 O -(CH2)PCONR7R8, DONDE R7 Y R8, QUE PUEDEN SER EL MISMO O DIFRENETES, SON CADA UNO UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-C4 O ALQUENILO C3-C4, O JUNTO CON EL ATOMO DE N AL QUE ESTAN UNIDOS FORMAN UN ANILLO SATURADO DE 5-7 MIEMBROS; Y P ES 1, 2 O 3; (CH2)QNR9R10, DONDE R9 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-C4 , Y R10 ES UN GRUPO -COR11 O -SO2R11, DONDE R11 ES UN GRUPO ALQUILO C1-C4, Y Q ES 0, 1, 2 O 3, O -(CH2)CO2R11, SIENDO R11 COMO SE DEFINIO ANTES, Q'' ES UN ATOMO DE FLUOR; Y SUS SALES Y SOLVATOS FISIOLOGICAMENTE ACEPTABLES; LOS COMPUESTOS SON PODEROSOS Y SELECTIVOS ANTAGONISTAS DEL EFECTO DE 5-HT EN RECEPTORES 5HT3 Y SON UTILES, POR EJEMPLO, EN EL TRATAMIENTO DE DESORDENES PSICOTICOS, ANSIEDAD, NAUSEAS Y VOMITOS.
ES89307788T 1988-08-02 1989-08-01 Derivados de lactamas. Expired - Lifetime ES2088389T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888818393A GB8818393D0 (en) 1988-08-02 1988-08-02 Chemical compounds
GB898904195A GB8904195D0 (en) 1989-02-23 1989-02-23 Chemical compounds
GB898904550A GB8904550D0 (en) 1989-02-28 1989-02-28 Chemical compounds
HU90608A HU207078B (en) 1988-08-02 1990-01-31 Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds

Publications (1)

Publication Number Publication Date
ES2088389T3 true ES2088389T3 (es) 1996-08-16

Family

ID=27450153

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89307788T Expired - Lifetime ES2088389T3 (es) 1988-08-02 1989-08-01 Derivados de lactamas.

Country Status (14)

Country Link
EP (1) EP0353983B1 (es)
JP (1) JPH02160786A (es)
AT (1) ATE138659T1 (es)
AU (1) AU631131B2 (es)
CA (1) CA1336906C (es)
DE (1) DE68926553T2 (es)
DK (1) DK169922B1 (es)
ES (1) ES2088389T3 (es)
FI (1) FI92067C (es)
GR (1) GR3020349T3 (es)
IL (1) IL91167A (es)
NO (1) NO169714C (es)
NZ (1) NZ230154A (es)
PT (1) PT91336B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25493A (en) * 1987-09-03 1991-07-24 Glaxo Group Ltd 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same
GB8904552D0 (en) 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical process
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments
GB9011469D0 (en) * 1990-05-23 1990-07-11 Glaxo Group Ltd Chemical process
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
GB9216154D0 (en) * 1992-07-30 1992-09-09 Glaxo Group Ltd Chemical compounds
EP0581388A1 (en) * 1992-07-30 1994-02-02 Glaxo Group Limited Pyridoindolone Methansulphonate as 5HT and 5HT3 receptor antagonists
US5962448A (en) * 1995-12-01 1999-10-05 Suntory Limited Pyrroloazepine derivatives
JP2004502642A (ja) * 2000-02-11 2004-01-29 ブリストル−マイヤーズ　スクイブ　カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用
MXPA04001203A (es) * 2001-08-08 2004-05-20 Pharmacia & Upjhon Company 1-h-pirido[4,3-b] indoles terapeuticos.
CA2473392A1 (en) 2002-01-18 2003-07-31 Aryx Therapeutics 5-ht3 receptor antagonists and methods of use
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
CN101309903B (zh) * 2005-11-16 2012-10-03 弗·哈夫曼-拉罗切有限公司 制备thoc的新方法
RU2007139634A (ru) * 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
CN102480955B (zh) 2009-04-29 2015-08-05 梅迪维新技术公司 吡啶并[4,3-b]吲哚类和使用方法
CA2760516A1 (en) 2009-04-29 2011-02-17 Medivation Technologies, Inc. Pyrido[4,3-b]indoles and methods of use
JP5955767B2 (ja) 2009-05-20 2016-07-20 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 損傷性前庭障害の処置における使用のためのセロトニン５−ｈｔ３受容体拮抗薬
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
PH25493A (en) * 1987-09-03 1991-07-24 Glaxo Group Ltd 2,3,4,5-tetrahydro-2-£(imidazol-(or-5)-yl)methyl-ih-pyrido£4,3-b|indol-1-ones , derivatives having 5-ht antagonist activity 3
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same

Also Published As

Publication number Publication date
EP0353983A3 (en) 1990-07-25
AU3918689A (en) 1990-02-08
AU631131B2 (en) 1992-11-19
NZ230154A (en) 1991-10-25
DE68926553D1 (de) 1996-07-04
JPH02160786A (ja) 1990-06-20
GR3020349T3 (en) 1996-09-30
NO893101D0 (no) 1989-08-01
EP0353983A2 (en) 1990-02-07
IL91167A0 (en) 1990-03-19
FI92067C (fi) 1994-09-26
FI92067B (fi) 1994-06-15
DK377889D0 (da) 1989-08-01
NO169714B (no) 1992-04-21
FI893634A0 (fi) 1989-08-01
CA1336906C (en) 1995-09-05
IL91167A (en) 1993-06-10
NO169714C (no) 1992-07-29
ATE138659T1 (de) 1996-06-15
DE68926553T2 (de) 1996-10-17
PT91336A (pt) 1990-03-08
FI893634A (fi) 1990-02-03
DK169922B1 (da) 1995-04-03
EP0353983B1 (en) 1996-05-29
PT91336B (pt) 1995-05-04
NO893101L (no) 1990-02-05
DK377889A (da) 1990-02-03

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