ATE78254T1 - Indol-derivate. - Google Patents
Indol-derivate.Info
- Publication number
- ATE78254T1 ATE78254T1 AT88300522T AT88300522T ATE78254T1 AT E78254 T1 ATE78254 T1 AT E78254T1 AT 88300522 T AT88300522 T AT 88300522T AT 88300522 T AT88300522 T AT 88300522T AT E78254 T1 ATE78254 T1 AT E78254T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- 6alkyl
- phenylc1
- phenyl
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- -1 C3-6alkenyl Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 102000035037 5-HT3 receptors Human genes 0.000 abstract 1
- 108091005477 5-HT3 receptors Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878701494A GB8701494D0 (en) | 1987-01-23 | 1987-01-23 | Chemical compounds |
| EP88300522A EP0276163B1 (de) | 1987-01-23 | 1988-01-22 | Indol-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE78254T1 true ATE78254T1 (de) | 1992-08-15 |
Family
ID=10611114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88300522T ATE78254T1 (de) | 1987-01-23 | 1988-01-22 | Indol-derivate. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0276163B1 (de) |
| JP (1) | JPS63270679A (de) |
| AT (1) | ATE78254T1 (de) |
| DE (1) | DE3872722D1 (de) |
| GB (1) | GB8701494D0 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
| GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
| US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
| EP0387431A1 (de) * | 1989-03-14 | 1990-09-19 | Beecham Group Plc | Imidazolderivate, Verfahren zu deren Herstellung und deren Anwendung als pharmazeutische Mittel |
| ES2061024T3 (es) | 1989-04-21 | 1994-12-01 | Sandoz Ag | Uso terapeutico de antagonistas de receptores de 5-ht3. |
| US5126343A (en) * | 1989-09-11 | 1992-06-30 | G. D. Searle & Co. | N-azabicyclo [3.3.0]octane amides of aromatic acids |
| GB8928837D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459770A (en) * | 1966-12-07 | 1969-08-05 | American Home Prod | Indoleglyoxyloylpyrroles |
| EP0003901B1 (de) * | 1978-02-24 | 1981-08-05 | Pfizer Limited | 3-(Imidazol-1-ylalkyl) indole als selektive Thromboxansynthetase Hemmungsmittel, pharmazeutische Zusammensetzungen die diese enthalten und Verfahren zu ihrer Herstellung |
| EP0191562B1 (de) * | 1985-01-23 | 1991-07-10 | Glaxo Group Limited | Tetrahydrocarbazolonderivate |
| DE3771376D1 (de) * | 1986-03-17 | 1991-08-22 | Glaxo Group Ltd | Indol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
-
1987
- 1987-01-23 GB GB878701494A patent/GB8701494D0/en active Pending
-
1988
- 1988-01-22 EP EP88300522A patent/EP0276163B1/de not_active Expired - Lifetime
- 1988-01-22 AT AT88300522T patent/ATE78254T1/de not_active IP Right Cessation
- 1988-01-22 JP JP63012415A patent/JPS63270679A/ja active Pending
- 1988-01-22 DE DE8888300522T patent/DE3872722D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63270679A (ja) | 1988-11-08 |
| EP0276163B1 (de) | 1992-07-15 |
| EP0276163A2 (de) | 1988-07-27 |
| DE3872722D1 (de) | 1992-08-20 |
| EP0276163A3 (en) | 1988-11-30 |
| GB8701494D0 (en) | 1987-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |