ES2038532B1 - Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. - Google Patents
Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.Info
- Publication number
- ES2038532B1 ES2038532B1 ES9101147A ES9101147A ES2038532B1 ES 2038532 B1 ES2038532 B1 ES 2038532B1 ES 9101147 A ES9101147 A ES 9101147A ES 9101147 A ES9101147 A ES 9101147A ES 2038532 B1 ES2038532 B1 ES 2038532B1
- Authority
- ES
- Spain
- Prior art keywords
- piperacinilbecimidazole
- procedure
- preparation
- group
- new derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DE 2-PIPERACINILBENCIMIDAZOL. SE DESCRIBE LA PREPARACION DE NUEVOS DERIVADOS DE 2-PIPERACINILBENCIMIDAZOL, DE FORMULA GENERAL FORMULA EN DONDE R PUEDE SER UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE CADENA CORTA, Y UN RADICAL FENILO SUSTITUIDO O NO EN LA POSICION CUATRO POR UN HALOGENO, Y RSI1 PUEDE SER UN ATOMO DE HIDROGENO, UN RADICAL ALCOXICARBONILO, UN GRUPO HIDROXIMETILO, Y UN GRUPO DIFENILMETILO, ASI COMO SUS SALES DE ADICION CON ACIDOS FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD FARMACOLOGICA COMO ANTAGONISTAS DE LOS RECEPTORES 5HTSI3 LA SEROTONINA.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9101147A ES2038532B1 (es) | 1991-05-10 | 1991-05-10 | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. |
PT97882A PT97882B (pt) | 1991-05-10 | 1991-06-06 | Processo de preparacao de novos derivados de 2-piperazinilbenzimidazol |
AU15970/92A AU666477B2 (en) | 1991-05-10 | 1992-05-01 | 2-piperazinylbenzimidazole derivatives and processes for the preparation thereof |
KR1019920007702A KR100227458B1 (ko) | 1991-05-10 | 1992-05-07 | 신규 2-피페라지닐벤즈이미다졸 유도체 |
ZA923319A ZA923319B (en) | 1991-05-10 | 1992-05-07 | A process for preparing new 2-piperazinylbenzimidazole derivatives |
DE69229845T DE69229845T2 (de) | 1991-05-10 | 1992-05-08 | 2-Piperazinylbenzimidazolderivate |
CA002068292A CA2068292A1 (en) | 1991-05-10 | 1992-05-08 | New 2-piperazinylbenzimidazole derivatives |
EP92500056A EP0512939B1 (en) | 1991-05-10 | 1992-05-08 | 2-piperazinylbenzimidazole derivatives |
AT92500056T ATE183741T1 (de) | 1991-05-10 | 1992-05-08 | 2-piperazinylbenzimidazolderivate |
DK92500056T DK0512939T3 (da) | 1991-05-10 | 1992-05-08 | 2-Piperazinylbenzimidazolderivater |
MX9202178A MX9202178A (es) | 1991-05-10 | 1992-05-11 | Nuevos derivados de 2-piperacinil bencimidazol. |
JP4144877A JPH072795A (ja) | 1991-05-10 | 1992-05-11 | 新規な2−ピペラジニルベンズイミダゾール誘導体 |
TW081104137A TW200478B (es) | 1991-05-10 | 1992-05-27 | |
US07/946,012 US5256665A (en) | 1991-05-10 | 1992-09-15 | Process for preparing new 2-piperazinylbenzimidazole |
GR990403022T GR3031930T3 (en) | 1991-05-10 | 1999-11-24 | New 2-piperazinylbenzimidazole derivatives. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9101147A ES2038532B1 (es) | 1991-05-10 | 1991-05-10 | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2038532A1 ES2038532A1 (es) | 1993-07-16 |
ES2038532B1 true ES2038532B1 (es) | 1994-02-16 |
Family
ID=8272328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9101147A Expired - Fee Related ES2038532B1 (es) | 1991-05-10 | 1991-05-10 | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0512939B1 (es) |
JP (1) | JPH072795A (es) |
KR (1) | KR100227458B1 (es) |
AT (1) | ATE183741T1 (es) |
AU (1) | AU666477B2 (es) |
CA (1) | CA2068292A1 (es) |
DE (1) | DE69229845T2 (es) |
DK (1) | DK0512939T3 (es) |
ES (1) | ES2038532B1 (es) |
GR (1) | GR3031930T3 (es) |
MX (1) | MX9202178A (es) |
PT (1) | PT97882B (es) |
TW (1) | TW200478B (es) |
ZA (1) | ZA923319B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201744B (es) * | 1991-07-02 | 1993-03-11 | Kanebou Textile Co Ltd | |
JP3193560B2 (ja) * | 1993-04-16 | 2001-07-30 | 明治製菓株式会社 | 新規ベンゾオキサゾール誘導体 |
ES2072193B1 (es) * | 1993-05-21 | 1996-02-16 | Espanola Prod Quimicos | Nuevos derivados del1-fenilmetil bencimidazol piperacinas. |
FR2731707B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
JP3520177B2 (ja) * | 1996-05-09 | 2004-04-19 | 明治製菓株式会社 | セロトニン5−ht3受容体部分活性薬 |
CA2671857C (en) * | 2007-01-25 | 2013-11-19 | Janssen Pharmaceutica Nv | 2-piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives |
WO2017044693A1 (en) | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4351832A (en) * | 1980-04-18 | 1982-09-28 | American Home Products Corporation | 2-(Piperazinyl)-4-pyrimidinamines |
JPS5879983A (ja) * | 1981-11-06 | 1983-05-13 | Kanebo Ltd | 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 |
US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
AU7997091A (en) * | 1990-05-30 | 1991-12-31 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
-
1991
- 1991-05-10 ES ES9101147A patent/ES2038532B1/es not_active Expired - Fee Related
- 1991-06-06 PT PT97882A patent/PT97882B/pt not_active IP Right Cessation
-
1992
- 1992-05-01 AU AU15970/92A patent/AU666477B2/en not_active Ceased
- 1992-05-07 ZA ZA923319A patent/ZA923319B/xx unknown
- 1992-05-07 KR KR1019920007702A patent/KR100227458B1/ko not_active IP Right Cessation
- 1992-05-08 AT AT92500056T patent/ATE183741T1/de not_active IP Right Cessation
- 1992-05-08 EP EP92500056A patent/EP0512939B1/en not_active Expired - Lifetime
- 1992-05-08 DE DE69229845T patent/DE69229845T2/de not_active Expired - Fee Related
- 1992-05-08 CA CA002068292A patent/CA2068292A1/en not_active Abandoned
- 1992-05-08 DK DK92500056T patent/DK0512939T3/da active
- 1992-05-11 JP JP4144877A patent/JPH072795A/ja active Pending
- 1992-05-11 MX MX9202178A patent/MX9202178A/es not_active IP Right Cessation
- 1992-05-27 TW TW081104137A patent/TW200478B/zh active
-
1999
- 1999-11-24 GR GR990403022T patent/GR3031930T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR100227458B1 (ko) | 1999-11-01 |
DE69229845D1 (de) | 1999-09-30 |
DE69229845T2 (de) | 2000-04-27 |
PT97882B (pt) | 1998-10-30 |
CA2068292A1 (en) | 1992-11-11 |
ATE183741T1 (de) | 1999-09-15 |
GR3031930T3 (en) | 2000-03-31 |
AU666477B2 (en) | 1996-02-15 |
MX9202178A (es) | 1992-11-01 |
ES2038532A1 (es) | 1993-07-16 |
JPH072795A (ja) | 1995-01-06 |
TW200478B (es) | 1993-02-21 |
DK0512939T3 (da) | 2000-03-13 |
EP0512939A1 (en) | 1992-11-11 |
AU1597092A (en) | 1992-11-12 |
ZA923319B (en) | 1994-02-07 |
PT97882A (pt) | 1993-04-30 |
KR920021527A (ko) | 1992-12-18 |
EP0512939B1 (en) | 1999-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040511 |