DE69414255D1 - Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten - Google Patents

Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten

Info

Publication number
DE69414255D1
DE69414255D1 DE69414255T DE69414255T DE69414255D1 DE 69414255 D1 DE69414255 D1 DE 69414255D1 DE 69414255 T DE69414255 T DE 69414255T DE 69414255 T DE69414255 T DE 69414255T DE 69414255 D1 DE69414255 D1 DE 69414255D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
condensed
receptor antagonists
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414255T
Other languages
English (en)
Other versions
DE69414255T2 (de
Inventor
Laramie Gaster
Paul WYMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69414255D1 publication Critical patent/DE69414255D1/de
Application granted granted Critical
Publication of DE69414255T2 publication Critical patent/DE69414255T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69414255T 1993-08-05 1994-07-28 Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten Expired - Fee Related DE69414255T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939316195A GB9316195D0 (en) 1993-08-05 1993-08-05 Pharmaceuticals
PCT/EP1994/002514 WO1995004737A1 (en) 1993-08-05 1994-07-28 Condensed indole derivatives as 5-ht4-receptor antagonists

Publications (2)

Publication Number Publication Date
DE69414255D1 true DE69414255D1 (de) 1998-12-03
DE69414255T2 DE69414255T2 (de) 1999-05-12

Family

ID=10739981

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414255T Expired - Fee Related DE69414255T2 (de) 1993-08-05 1994-07-28 Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten

Country Status (14)

Country Link
EP (1) EP0712406B1 (de)
JP (1) JPH09502168A (de)
CN (1) CN1131949A (de)
AT (1) ATE172732T1 (de)
AU (1) AU695034B2 (de)
CA (1) CA2168750A1 (de)
DE (1) DE69414255T2 (de)
DK (1) DK0712406T3 (de)
ES (1) ES2125481T3 (de)
GB (1) GB9316195D0 (de)
HK (1) HK1012347A1 (de)
NZ (1) NZ271972A (de)
WO (1) WO1995004737A1 (de)
ZA (1) ZA945773B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
EP0664794A1 (de) * 1992-10-16 1995-08-02 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl-carbonsäure ester/amide von kondensierten ring-systemen als 5-ht4-rezeptor antagonisten
ES2208870T3 (es) * 1996-02-15 2004-06-16 Janssen Pharmaceutica N.V. Uso de antagonistas del receptor 5ht4 para resolver los efectos gastrointestinales de los inhibidores de la reabsorcion de serotonina.
GB9820294D0 (en) * 1998-09-17 1998-11-11 Smithkline Beecham Plc Pharmaceuticals
CN101094852A (zh) 2004-11-01 2007-12-26 惠氏公司 作为cns活性剂的取代的吲嗪以及衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142981A (ja) * 1983-12-28 1985-07-29 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド誘導体
ES2132223T3 (es) * 1992-03-12 1999-08-16 Smithkline Beecham Plc Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4.

Also Published As

Publication number Publication date
HK1012347A1 (en) 1999-07-30
AU7609894A (en) 1995-02-28
ES2125481T3 (es) 1999-03-01
NZ271972A (en) 1997-07-27
EP0712406A1 (de) 1996-05-22
ATE172732T1 (de) 1998-11-15
AU695034B2 (en) 1998-08-06
EP0712406B1 (de) 1998-10-28
GB9316195D0 (en) 1993-09-22
CN1131949A (zh) 1996-09-25
DK0712406T3 (da) 1999-07-05
WO1995004737A1 (en) 1995-02-16
DE69414255T2 (de) 1999-05-12
JPH09502168A (ja) 1997-03-04
ZA945773B (en) 1996-02-05
CA2168750A1 (en) 1995-02-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee