ES2125481T3 - Derivados de indol condensados en calidad de antagonistas del receptor de 5-ht4. - Google Patents
Derivados de indol condensados en calidad de antagonistas del receptor de 5-ht4.Info
- Publication number
- ES2125481T3 ES2125481T3 ES94926128T ES94926128T ES2125481T3 ES 2125481 T3 ES2125481 T3 ES 2125481T3 ES 94926128 T ES94926128 T ES 94926128T ES 94926128 T ES94926128 T ES 94926128T ES 2125481 T3 ES2125481 T3 ES 2125481T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- receptor
- antagonists
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- -1 polymethylene chain Polymers 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000003523 serotonin 4 antagonist Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE PRESENTAN UN COMPUESTO DE LA FORMULA (IA) O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO, EN DONDE X ES O, S, SO, SO{SUB,2}, CH{SUB,2} O NR EN DONDE R ES HIDROGENO O ALQUILO C{SUB,1-4}; A ES UNA CADENA DE POLIMETILENO SATURADA O INSATURADA DE ENTRE 2 Y 4 ATOMOS DE CARBONO; R1 Y R2 SON HIDROGENO O ALQUILO C{SUB,1-6}, R3 ES HIDROGENO, HALO, ALQUILO C{SUB,1-6}, AMINO, NITRO O ALQUILO C{SUB,1-6}; R4 ES HIDROGENO, HALO ALQUILO C{SUB,1-6} O ALCOXIDO C{SUB,1-6}; Y ES O O NH; Z ES DE LA SUBFORMULA (A), EN DONDE N1 ES 1, 2, 3 O 4; Q ES 0, 1, 2 O 3; R5 ES 3-FENOXIPROPILO; O UN COMPUESTO DE LA FORMULA (IA) EN DONDE LA UNION CO-Y SE REEMPLAZA MEDIANTE UN BIOISOESTEREO HETEROCICLICO; LOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA CON EL RECEPTOR DEL 5-HT{SUB,4}.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939316195A GB9316195D0 (en) | 1993-08-05 | 1993-08-05 | Pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2125481T3 true ES2125481T3 (es) | 1999-03-01 |
Family
ID=10739981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94926128T Expired - Lifetime ES2125481T3 (es) | 1993-08-05 | 1994-07-28 | Derivados de indol condensados en calidad de antagonistas del receptor de 5-ht4. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0712406B1 (es) |
| JP (1) | JPH09502168A (es) |
| CN (1) | CN1131949A (es) |
| AT (1) | ATE172732T1 (es) |
| AU (1) | AU695034B2 (es) |
| CA (1) | CA2168750A1 (es) |
| DE (1) | DE69414255T2 (es) |
| DK (1) | DK0712406T3 (es) |
| ES (1) | ES2125481T3 (es) |
| GB (1) | GB9316195D0 (es) |
| NZ (1) | NZ271972A (es) |
| WO (1) | WO1995004737A1 (es) |
| ZA (1) | ZA945773B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5998409A (en) * | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5726187A (en) * | 1992-10-16 | 1998-03-10 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists |
| CA2237582C (en) * | 1996-02-15 | 2009-04-14 | Janssen Pharmaceutica N.V. | Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors |
| GB9820294D0 (en) * | 1998-09-17 | 1998-11-11 | Smithkline Beecham Plc | Pharmaceuticals |
| EP1807427A2 (en) | 2004-11-01 | 2007-07-18 | Wyeth | Substituted indolizines and derivatives as cns agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60142981A (ja) * | 1983-12-28 | 1985-07-29 | Yoshitomi Pharmaceut Ind Ltd | ３−インド−ルカルボキサミド誘導体 |
| CA2131797C (en) * | 1992-03-12 | 2010-05-18 | Laramie Mary Gaster | Condensed indole derivatives as 5ht4-receptor antagonists |
-
1993
- 1993-08-05 GB GB939316195A patent/GB9316195D0/en active Pending
-
1994
- 1994-07-28 JP JP7506201A patent/JPH09502168A/ja active Pending
- 1994-07-28 DE DE69414255T patent/DE69414255T2/de not_active Expired - Fee Related
- 1994-07-28 ES ES94926128T patent/ES2125481T3/es not_active Expired - Lifetime
- 1994-07-28 EP EP94926128A patent/EP0712406B1/en not_active Expired - Lifetime
- 1994-07-28 WO PCT/EP1994/002514 patent/WO1995004737A1/en not_active Ceased
- 1994-07-28 AU AU76098/94A patent/AU695034B2/en not_active Ceased
- 1994-07-28 AT AT94926128T patent/ATE172732T1/de not_active IP Right Cessation
- 1994-07-28 CN CN94193556A patent/CN1131949A/zh active Pending
- 1994-07-28 NZ NZ271972A patent/NZ271972A/en unknown
- 1994-07-28 DK DK94926128T patent/DK0712406T3/da active
- 1994-07-28 CA CA002168750A patent/CA2168750A1/en not_active Abandoned
- 1994-08-03 ZA ZA945773A patent/ZA945773B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995004737A1 (en) | 1995-02-16 |
| ZA945773B (en) | 1996-02-05 |
| DE69414255T2 (de) | 1999-05-12 |
| NZ271972A (en) | 1997-07-27 |
| ATE172732T1 (de) | 1998-11-15 |
| JPH09502168A (ja) | 1997-03-04 |
| DE69414255D1 (de) | 1998-12-03 |
| DK0712406T3 (da) | 1999-07-05 |
| CA2168750A1 (en) | 1995-02-16 |
| GB9316195D0 (en) | 1993-09-22 |
| HK1012347A1 (en) | 1999-07-30 |
| CN1131949A (zh) | 1996-09-25 |
| EP0712406A1 (en) | 1996-05-22 |
| EP0712406B1 (en) | 1998-10-28 |
| AU695034B2 (en) | 1998-08-06 |
| AU7609894A (en) | 1995-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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