EA200101176A1 - Циклокарбаматные производные в качестве модуляторов рецептора прогестерона - Google Patents
Циклокарбаматные производные в качестве модуляторов рецептора прогестеронаInfo
- Publication number
- EA200101176A1 EA200101176A1 EA200101176A EA200101176A EA200101176A1 EA 200101176 A1 EA200101176 A1 EA 200101176A1 EA 200101176 A EA200101176 A EA 200101176A EA 200101176 A EA200101176 A EA 200101176A EA 200101176 A1 EA200101176 A1 EA 200101176A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- alkyl
- alkoxy
- alkynyl
- alkoalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение обеспечивает соединения формулы (1), где Rи Rпредставляют собой индивидуальные заместители или Rи Rсконденсированы с образованием спироциклического кольца, гетероциклического кольца, Rпредставляет собой Н, ОН, NH, C-Cалкил, замещенный C-Cалкил, C-Cалкенил, замещенный C-Cалкенил, алкинил или замещенный алкинил, или COR; Rвыбирают из Н, C-Cалкила, замещенного C-Cалкила, арила, замещенного арила, C-Cалкокси, замещенного C-Cалкокси, C-Cаминоалкила или замещенного C-Cаминоалкила; Rвыбирают из Н, галогена, CN, NO, C-Cалкила, замещенного C-Cалкила, алкинила или замещенного алкинила, C-Cалкокси, замещенного C-Cалкокси, амино, C-Cаминоалкила или замещенного C-Cаминоалкила; Rвыбирают из тризамещенного бензольного пяти- или шестичленного кольца с 1, 2 или 3 гетероатомами в кольце, выбранными из группы О, S, S(О), S(O) или NR, содержащее один или два независимых заместителя из группы Н, галогена, CN, NOи C-Cалкила, C-Cалкокси, C-Cаминоалкила, CORили NRCOR; или его фармацевтически приемлемые соли, а также фармацевтические композиции и способы применения соединений в качестве антагонистов рецептора прогестерона.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18301299P | 1999-05-04 | 1999-05-04 | |
| US09/552,633 US6509334B1 (en) | 1999-05-04 | 2000-04-19 | Cyclocarbamate derivatives as progesterone receptor modulators |
| PCT/US2000/011822 WO2000066571A1 (en) | 1999-05-04 | 2000-05-01 | Cyclocarbamate derivatives as progesterone receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200101176A1 true EA200101176A1 (ru) | 2002-04-25 |
| EA004512B1 EA004512B1 (ru) | 2004-04-29 |
Family
ID=26878647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200101176A EA004512B1 (ru) | 1999-05-04 | 2000-05-01 | Циклокарбаматные производные в качестве модуляторов рецептора прогестерона |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1173426A1 (ru) |
| JP (1) | JP2002543193A (ru) |
| KR (1) | KR20010114250A (ru) |
| CN (1) | CN1145618C (ru) |
| AU (1) | AU766428B2 (ru) |
| BG (1) | BG106079A (ru) |
| BR (1) | BR0010213A (ru) |
| CA (1) | CA2371726A1 (ru) |
| CZ (1) | CZ20013951A3 (ru) |
| EA (1) | EA004512B1 (ru) |
| HU (1) | HUP0201609A3 (ru) |
| IL (1) | IL146280A0 (ru) |
| MX (1) | MXPA01011286A (ru) |
| NO (1) | NO321361B1 (ru) |
| NZ (1) | NZ515355A (ru) |
| PL (1) | PL351127A1 (ru) |
| SG (1) | SG114650A1 (ru) |
| SK (1) | SK15912001A3 (ru) |
| TR (1) | TR200103286T2 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1756095T3 (pl) * | 2004-04-27 | 2008-10-31 | Wyeth Corp | Cyjanopirole zawierające cykliczne karbaminianowe i tiokarbaminianowe biaryle oraz sposoby ich wytwarzania |
| JPWO2006077821A1 (ja) * | 2005-01-19 | 2008-06-19 | 大日本住友製薬株式会社 | アルドステロン受容体調節剤としての芳香族スルホン化合物 |
| CA2701406C (en) | 2007-10-05 | 2016-01-26 | Banyu Pharmaceutical Co., Ltd. | Benzoxazinone derivative |
| CN111925353B (zh) * | 2020-08-31 | 2022-04-08 | 苏州大学附属第二医院 | 一种2-噻吩甲腈的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
| WO1995020389A1 (en) * | 1994-01-28 | 1995-08-03 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
| EP1382597A3 (en) * | 1994-12-22 | 2004-04-07 | Ligand Pharmaceuticals, Inc. | Steroid receptor modulator compounds and methods |
| EP0929533B1 (en) * | 1996-10-02 | 2003-09-03 | Bristol-Myers Squibb Pharma Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same |
-
2000
- 2000-05-01 EP EP00928689A patent/EP1173426A1/en not_active Withdrawn
- 2000-05-01 CZ CZ20013951A patent/CZ20013951A3/cs unknown
- 2000-05-01 MX MXPA01011286A patent/MXPA01011286A/es unknown
- 2000-05-01 EA EA200101176A patent/EA004512B1/ru not_active IP Right Cessation
- 2000-05-01 NZ NZ515355A patent/NZ515355A/xx unknown
- 2000-05-01 CA CA002371726A patent/CA2371726A1/en not_active Abandoned
- 2000-05-01 SK SK1591-2001A patent/SK15912001A3/sk unknown
- 2000-05-01 KR KR1020017013970A patent/KR20010114250A/ko not_active Application Discontinuation
- 2000-05-01 AU AU46886/00A patent/AU766428B2/en not_active Ceased
- 2000-05-01 JP JP2000615601A patent/JP2002543193A/ja active Pending
- 2000-05-01 SG SG200400080A patent/SG114650A1/en unknown
- 2000-05-01 BR BR0010213-0A patent/BR0010213A/pt not_active Application Discontinuation
- 2000-05-01 HU HU0201609A patent/HUP0201609A3/hu unknown
- 2000-05-01 CN CNB008071004A patent/CN1145618C/zh not_active Expired - Fee Related
- 2000-05-01 PL PL00351127A patent/PL351127A1/xx not_active Application Discontinuation
- 2000-05-01 TR TR2001/03286T patent/TR200103286T2/xx unknown
- 2000-05-01 IL IL14628000A patent/IL146280A0/xx unknown
-
2001
- 2001-11-02 BG BG106079A patent/BG106079A/xx unknown
- 2001-11-02 NO NO20015378A patent/NO321361B1/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1145618C (zh) | 2004-04-14 |
| AU766428B2 (en) | 2003-10-16 |
| AU4688600A (en) | 2000-11-17 |
| NZ515355A (en) | 2004-02-27 |
| JP2002543193A (ja) | 2002-12-17 |
| MXPA01011286A (es) | 2003-07-14 |
| KR20010114250A (ko) | 2001-12-31 |
| CN1349517A (zh) | 2002-05-15 |
| EP1173426A1 (en) | 2002-01-23 |
| CA2371726A1 (en) | 2000-11-09 |
| TR200103286T2 (tr) | 2002-07-22 |
| NO20015378D0 (no) | 2001-11-02 |
| SG114650A1 (en) | 2005-09-28 |
| BG106079A (en) | 2002-05-31 |
| PL351127A1 (en) | 2003-03-24 |
| BR0010213A (pt) | 2002-02-19 |
| SK15912001A3 (sk) | 2002-06-04 |
| CZ20013951A3 (cs) | 2002-05-15 |
| IL146280A0 (en) | 2002-07-25 |
| NO321361B1 (no) | 2006-05-02 |
| HUP0201609A2 (en) | 2002-08-28 |
| NO20015378L (no) | 2002-01-03 |
| EA004512B1 (ru) | 2004-04-29 |
| HUP0201609A3 (en) | 2002-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA72917C2 (en) | Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor | |
| EA200600925A1 (ru) | Производные триазола в качестве антагонистов вазопрессина | |
| EA200100486A1 (ru) | Производные 2-уреидотиазола, способ их получения и применение указанных веществ в качестве противоопухолевых средств | |
| DE60140456D1 (de) | Aza heterocyclische derivate und ihre therapeutische verwendung | |
| PE20070212A1 (es) | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen | |
| WO2000066564A8 (en) | Benzimidazolones and analogues and their use as progesterone receptor ligands | |
| AR004219A1 (es) | Nuevos derivados de quinazolina, procedimientos para su preparacion, composiciones que los contienen y su uso en la preparacion de medicamentos,particularmente en el tratamiento de trastornos inflamatorios | |
| HUP0300565A2 (hu) | PDE 5 inhibitor hatású 8-kinolin-xantin- és 8-izo-kinolin-xantin-származékok, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| BR0110112A (pt) | Derivados de pirrolidina e piperidina e seu uso para o tratamento de distúrbios neurodegenerativos | |
| EA200300064A1 (ru) | Карбоксамидные соединения и их применение в качестве антагонистов 11cby-рецептора человека | |
| AR035153A1 (es) | Derivados de carboxamidas y cetonas de dihidrobenzodioxina | |
| EA200100902A1 (ru) | Производные тетрагидропирана и их использование в качестве терапевтических агентов | |
| HRP20090264T1 (en) | Phenyl-piperazin methanone derivatives | |
| EA200101181A1 (ru) | Циклотиокарбаматные производные в качестве модуляторов рецептора прогестерона | |
| DE60111464D1 (de) | Azabicycloalkan-Derivate zur Verwendung als Inhibitoren der Serotonin-Wiederaufnahme und als 5HT2a Antagonisten | |
| DK0902018T3 (da) | 2-(arylpheny)amino-imidazolinderivater | |
| EA200101176A1 (ru) | Циклокарбаматные производные в качестве модуляторов рецептора прогестерона | |
| CY1108837T1 (el) | ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5 | |
| AR023111A1 (es) | Derivados de sulfonamida utiles como antagonistas del receptor 5-ht7, un procedimiento para su preparacion y composicion farmaceutica que los comprenden | |
| DE60013798D1 (de) | Empfängnisverhütende zusammensetzungen die progestagen und progesteronantagonisten enthalten | |
| BR0004548A (pt) | Derivados i de quinolin-4-ila | |
| AR027454A1 (es) | Derivados de beta-alanina, utiles como antagonistas de receptores, las composiciones farmaceuticas que las contienen y el uso de los mismos para lapreparacion de medicamentos | |
| EA200401077A1 (ru) | 2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b | |
| DK0712406T3 (da) | Kondenserende indolderivater som 5-HT4-receptorantagonister | |
| AR029744A1 (es) | Procedimiento para preparar tioamidas ciclicas y compuestos utiles en dicho procedimiento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |