AR029744A1 - Procedimiento para preparar tioamidas ciclicas y compuestos utiles en dicho procedimiento - Google Patents
Procedimiento para preparar tioamidas ciclicas y compuestos utiles en dicho procedimientoInfo
- Publication number
- AR029744A1 AR029744A1 ARP000101386A ARP000101386A AR029744A1 AR 029744 A1 AR029744 A1 AR 029744A1 AR P000101386 A ARP000101386 A AR P000101386A AR P000101386 A ARP000101386 A AR P000101386A AR 029744 A1 AR029744 A1 AR 029744A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- thioamids
- useful compounds
- prepare cyclic
- useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
La presente se refiere a un procedimiento para preparar un compuesto de formula (1), en el que b, 0, 1, 2 o 3, Y es oxígeno, azufre, NH o N-acetilo y cada R3 se selecciona independientemente entre el grupo que consta de halo, ciano, alquilo (C1-6), alcoxi (C1-6) y trifluormetilo, util para preparar nuevas aralquil- y aralquiliden-lactamas e -imidas heterocíclicas que son agentes agonistas y antagonistas selectivos de receptores de serotonina 1 (5-HT1). Se describen también los compuestos (2), (3) y (4) utiles en dichos procesos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12683199P | 1999-03-30 | 1999-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029744A1 true AR029744A1 (es) | 2003-07-16 |
Family
ID=22426907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101386A AR029744A1 (es) | 1999-03-30 | 2000-03-28 | Procedimiento para preparar tioamidas ciclicas y compuestos utiles en dicho procedimiento |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6388127B1 (es) |
| EP (1) | EP1041070B1 (es) |
| JP (1) | JP3566175B2 (es) |
| KR (1) | KR100386524B1 (es) |
| CN (2) | CN1163490C (es) |
| AR (1) | AR029744A1 (es) |
| AT (1) | ATE277025T1 (es) |
| AU (1) | AU777097B2 (es) |
| BR (1) | BR0001492A (es) |
| CA (1) | CA2302727C (es) |
| CZ (1) | CZ298140B6 (es) |
| DE (1) | DE60013942T2 (es) |
| DK (1) | DK1041070T3 (es) |
| ES (1) | ES2226715T3 (es) |
| HK (2) | HK1032053A1 (es) |
| HU (1) | HUP0001327A3 (es) |
| ID (1) | ID25428A (es) |
| IL (1) | IL135243A (es) |
| IN (1) | IN188844B (es) |
| PL (1) | PL196446B1 (es) |
| PT (1) | PT1041070E (es) |
| RU (1) | RU2219173C2 (es) |
| TR (1) | TR200000834A2 (es) |
| TW (1) | TW460472B (es) |
| YU (1) | YU15500A (es) |
| ZA (1) | ZA200001536B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2226715T3 (es) * | 1999-03-30 | 2005-04-01 | Pfizer Products Inc. | Procedimiento para preparar tioamidas ciclicas. |
| WO2014039715A1 (en) * | 2012-09-07 | 2014-03-13 | University Of Rochester | Methods and compositions for site-specific labeling of peptides and proteins |
| US9999921B2 (en) | 2015-06-15 | 2018-06-19 | Gm Global Technology Operatioins Llc | Method of making aluminum or magnesium based composite engine blocks or other parts with in-situ formed reinforced phases through squeeze casting or semi-solid metal forming and post heat treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2755278A (en) * | 1956-07-17 | Thiamori | ||
| WO1994003652A1 (en) | 1992-07-31 | 1994-02-17 | Yokota Corporation Co., Ltd. | Method of making metal of high purity from scrap of worked metal |
| GB9225377D0 (en) * | 1992-12-04 | 1993-01-27 | Ici Plc | Herbicides |
| UA56185C2 (uk) * | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування |
| ES2226715T3 (es) * | 1999-03-30 | 2005-04-01 | Pfizer Products Inc. | Procedimiento para preparar tioamidas ciclicas. |
-
2000
- 2000-03-15 ES ES00302110T patent/ES2226715T3/es not_active Expired - Lifetime
- 2000-03-15 EP EP00302110A patent/EP1041070B1/en not_active Expired - Lifetime
- 2000-03-15 DK DK00302110T patent/DK1041070T3/da active
- 2000-03-15 AT AT00302110T patent/ATE277025T1/de not_active IP Right Cessation
- 2000-03-15 YU YU15500A patent/YU15500A/sh unknown
- 2000-03-15 DE DE60013942T patent/DE60013942T2/de not_active Expired - Fee Related
- 2000-03-15 PT PT00302110T patent/PT1041070E/pt unknown
- 2000-03-23 IL IL13524300A patent/IL135243A/xx not_active IP Right Cessation
- 2000-03-27 IN IN273MU2000 patent/IN188844B/en unknown
- 2000-03-27 ID IDP20000242D patent/ID25428A/id unknown
- 2000-03-27 TW TW089105600A patent/TW460472B/zh not_active IP Right Cessation
- 2000-03-27 ZA ZA200001536A patent/ZA200001536B/xx unknown
- 2000-03-28 US US09/536,576 patent/US6388127B1/en not_active Expired - Fee Related
- 2000-03-28 BR BR0001492-3A patent/BR0001492A/pt not_active IP Right Cessation
- 2000-03-28 AU AU22635/00A patent/AU777097B2/en not_active Ceased
- 2000-03-28 AR ARP000101386A patent/AR029744A1/es unknown
- 2000-03-28 CA CA002302727A patent/CA2302727C/en not_active Expired - Fee Related
- 2000-03-29 TR TR2000/00834A patent/TR200000834A2/xx unknown
- 2000-03-29 HU HU0001327A patent/HUP0001327A3/hu unknown
- 2000-03-29 KR KR10-2000-0015986A patent/KR100386524B1/ko not_active IP Right Cessation
- 2000-03-29 RU RU2000107951/04A patent/RU2219173C2/ru not_active IP Right Cessation
- 2000-03-29 CZ CZ20001142A patent/CZ298140B6/cs not_active IP Right Cessation
- 2000-03-29 JP JP2000090837A patent/JP3566175B2/ja not_active Expired - Fee Related
- 2000-03-29 PL PL339287A patent/PL196446B1/pl unknown
- 2000-03-30 CN CNB001048325A patent/CN1163490C/zh not_active Expired - Fee Related
- 2000-03-30 CN CNB2004100014528A patent/CN1290829C/zh not_active Expired - Fee Related
-
2001
- 2001-04-12 HK HK01102637A patent/HK1032053A1/xx not_active IP Right Cessation
-
2004
- 2004-09-17 HK HK04107139A patent/HK1064364A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |