AR042273A1 - Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen - Google Patents

Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen

Info

Publication number
AR042273A1
AR042273A1 ARP030104441A ARP030104441A AR042273A1 AR 042273 A1 AR042273 A1 AR 042273A1 AR P030104441 A ARP030104441 A AR P030104441A AR P030104441 A ARP030104441 A AR P030104441A AR 042273 A1 AR042273 A1 AR 042273A1
Authority
AR
Argentina
Prior art keywords
amino
optionally substituted
hydroxy
alkyl
alkoxy
Prior art date
Application number
ARP030104441A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2002953019A external-priority patent/AU2002953019A0/en
Priority claimed from AU2002953602A external-priority patent/AU2002953602A0/en
Priority claimed from AU2003902015A external-priority patent/AU2003902015A0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of AR042273A1 publication Critical patent/AR042273A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de pirazol de la fórmula (1), en donde R1 es hidrógeno o alquilo inferior; R2 es alquilo inferior opcionalmente sustituido con halógeno, hidroxi, alcoxiimino inferior o alcoxi inferior; alquenilo inferior; cicloalquilo; ciano; alcanoilo inferior; cicloalquilcarbonilo; N,N-di-alquilcarbamoilo (inferior); carbamoilo; N-alcoxi inferior-N-alquilcarbamoilo inferior; amino; dialquilamino (inferior); alcoxicarbonilamino inferior; N,N-dialquilcarbamoilamino (inferior); N-(N,N-dialquilcarbamoilo (inferior)-N-alquilamino inferior; halógeno; hidroxi; carboxi; alcoxicarbonilo inferior; aroilo, heterociclicarbonilo; grupo heterocíclico; alquilsulfonilo inferior; alcoxi inferior opcionalmente sustituido con alcoxi inferior, N-N-dialquilcarbamoilo (inferior) o halógeno; cicloalquiloxi; alquiltio inferior; o alquilsulfinilo inferior; R3 es alquilo inferior opcionalmente sustituido con amino, carbamoilamino o alquilsulfonilamino inferior, halógeno; ciano; hidroxi; alcanoiloxi inferior; alquilendioxi inferior; alcoxi inferior opcionalmente sustituido con arilo, hidroxi, ciano, amino, alcoxicarbonilamino inferior, alquilsulfonilamino inferior o carbamoilamino; nitro; amino, grupo heterocíclico; alquiltio inferior; alquilsulfinilo inferior; o alquilsulfonilo inferior; R4 es hidrógeno; ciano; amino opcionalmente sustituido con ftaloílo o alquilo inferior; arilo; grupo heterocíclico; alcoxi inferior; hidroxi; alquilsulfoniloxi inferior; alcanoiloxi inferior; alquilo inferior sustituido con tritilamino y alcoxicarbonilo inferior, amino y alcoxicarbonilo inferior, amino y carboxi, amino y carbamoilo, o amino e hidroxi; N-alcoxicarbonilo inferior-N-alquilamino inferior; alcanoilo inferior opcionalmente sustituido con halógeno; carboxi; alquilsulfonilo inferior; sulfo; alquilsililoxi inferior; alcoxicarbonilo inferior; sulfamoilo opcionalmente sustituido con alquilo inferior; carbamoilo opcionalmente sustituido con alquilo inferior; alquiltio inferior; alquilsulfinilo inferior; carbamoiloxi; tioureido; o un grupo de la fórmula R5-G-J-, en la cual G es -CO- o -SO2-; j es -N(R6)- (donde R6 es hidrógeno o alquilo inferior); y R5 es amino opcionalmente sustituido con alcoxicarbonilo inferior o alquilo inferior; alquilo inferior opcionalmente sustituido con hidroxi, alcoxicarbonilamino inferior, alcanoiloxi inferior; amino o halógeno; alcoxi inferior; hidrógeno; grupo heterocíclico; o arilo; X es O, S, SO o SO2; Y es CH o N; Z es alquileno inferior o alquenileno inferior; y m es 0 ó 1; siempre que cuando R4 es hidrógeno; entonces R3 es alquilo inferior sustituido con amino, carbamoilamino o alquilsulfonilamino inferior; o alcoxi inferior sustituido con arilo, hidroxi, ciano, amino, alcoxicarbonilamino inferior, alquilsulfonilamino inferior o carbamoilamino; o sales de los mismos. El proceso para preparar dichos compuestos de fórmula (1), y las composiciones farmacéuticas que los contienen.
ARP030104441A 2002-12-02 2003-12-02 Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen AR042273A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2002953019A AU2002953019A0 (en) 2002-12-02 2002-12-02 Azole derivatives
AU2002953602A AU2002953602A0 (en) 2002-12-30 2002-12-30 New compounds
AU2003902015A AU2003902015A0 (en) 2003-04-29 2003-04-29 Azole derivatives

Publications (1)

Publication Number Publication Date
AR042273A1 true AR042273A1 (es) 2005-06-15

Family

ID=32474716

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104441A AR042273A1 (es) 2002-12-02 2003-12-02 Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen

Country Status (16)

Country Link
US (2) US7183306B2 (es)
EP (1) EP1567503B1 (es)
JP (1) JP4419078B2 (es)
KR (1) KR20050083761A (es)
AR (1) AR042273A1 (es)
AT (1) ATE538097T1 (es)
BR (1) BR0316332A (es)
CA (1) CA2505945A1 (es)
ES (1) ES2379076T3 (es)
HK (1) HK1087102A1 (es)
MX (1) MXPA05005742A (es)
NO (1) NO20053215L (es)
NZ (1) NZ540515A (es)
PL (1) PL377778A1 (es)
TW (1) TW200410942A (es)
WO (1) WO2004050632A1 (es)

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CN100421632C (zh) 2005-02-01 2008-10-01 金磊 人工心脏瓣膜成形环

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ATE538097T1 (de) 2012-01-15
CA2505945A1 (en) 2004-06-17
NO20053215D0 (no) 2005-06-30
MXPA05005742A (es) 2005-08-16
JP2006514095A (ja) 2006-04-27
PL377778A1 (pl) 2006-02-20
HK1087102A1 (en) 2006-10-06
NZ540515A (en) 2008-01-31
US20040116475A1 (en) 2004-06-17
US20070112037A1 (en) 2007-05-17
EP1567503B1 (en) 2011-12-21
JP4419078B2 (ja) 2010-02-24
BR0316332A (pt) 2005-09-27
KR20050083761A (ko) 2005-08-26
US7183306B2 (en) 2007-02-27
WO2004050632A1 (en) 2004-06-17
ES2379076T3 (es) 2012-04-20
TW200410942A (en) 2004-07-01
NO20053215L (no) 2005-09-01

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