FR2882365B1 - Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique - Google Patents
Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutiqueInfo
- Publication number
- FR2882365B1 FR2882365B1 FR0501860A FR0501860A FR2882365B1 FR 2882365 B1 FR2882365 B1 FR 2882365B1 FR 0501860 A FR0501860 A FR 0501860A FR 0501860 A FR0501860 A FR 0501860A FR 2882365 B1 FR2882365 B1 FR 2882365B1
- Authority
- FR
- France
- Prior art keywords
- pyrazol
- diphenyl
- preparation
- therapeutic use
- oxadiazole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ZNYFURJORHVVAQ-UHFFFAOYSA-N 2-(1,5-diphenylpyrazol-3-yl)-1,3,4-oxadiazole Chemical class O1C=NN=C1C1=NN(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1 ZNYFURJORHVVAQ-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0501860A FR2882365B1 (fr) | 2005-02-21 | 2005-02-21 | Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique |
PE2006000202A PE20061038A1 (es) | 2005-02-21 | 2006-02-17 | Derivados del 1,5-difenil-1h-pirazol-3-il) oxadiazol como agentes antagonistas cb1 y su preparacion |
MX2007009994A MX2007009994A (es) | 2005-02-21 | 2006-02-17 | Derivados del (1,5-difenil-1h-pirazol-3-il)oxadiazol, su preparacion y su aplicacion en terapeutica. |
KR1020077019014A KR20070107053A (ko) | 2005-02-21 | 2006-02-17 | (1,5-디페닐-1h-피라졸-3-일)옥사디아졸 유도체, 그의제조 방법 및 그의 치료제로서의 용도 |
CA002597359A CA2597359A1 (fr) | 2005-02-21 | 2006-02-17 | Derives de (1,5-diphenyl-1h-pyrazol-3-yl)oxadiazole, leur preparation et leur application en therapeutique |
EP06709338A EP1853595A1 (fr) | 2005-02-21 | 2006-02-17 | Derives de (1,5-diphenyl-1h-pyrazol-3-yl)oxadiazole, leur preparation et leur application en therapeutique |
CNA2006800049844A CN101119990A (zh) | 2005-02-21 | 2006-02-17 | (1,5-二苯基-1h-吡唑-3-基)二唑衍生物,它们的制备及在治疗中的应用 |
EA200701779A EA200701779A1 (ru) | 2005-02-21 | 2006-02-17 | Производные (1,5-дифенил-1н-пиразол-3-ил)оксадиазола, их получение и их применение в терапии |
NZ560790A NZ560790A (en) | 2005-02-21 | 2006-02-17 | (1,5-diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics |
BRPI0606845-6A BRPI0606845A2 (pt) | 2005-02-21 | 2006-02-17 | derivados de (1,5-difenil-1h-pirazol-3-il)oxadiazol, o respectivo preparo e a respectiva aplicação em terapêutica |
PCT/FR2006/000368 WO2006087480A1 (fr) | 2005-02-21 | 2006-02-17 | DERIVES DE (l,5-DIPHENYL-lH-PYRAZOL-3-YL)OXADIAZOLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
JP2007555667A JP4812778B2 (ja) | 2005-02-21 | 2006-02-17 | (1,5−ジフェニル−1h−ピラゾール−3−イル)オキサジアゾール誘導体、この調製方法および治療剤におけるこの使用 |
ZA200706953A ZA200706953B (en) | 2005-02-21 | 2006-02-17 | (1,5-diphenyl-1h-pyrazol-3-yl) oxadiazole derivatives, preparation method thereof and use same in therapeutics |
AU2006215443A AU2006215443A1 (en) | 2005-02-21 | 2006-02-17 | (1,5-Diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics |
DO2006000045A DOP2006000045A (es) | 2005-02-21 | 2006-02-20 | Derivados del (1,5-difenil-1h-pirazol-3-il oxadiazol, su preparacion y su aplicacion en terapeutica |
TW095105632A TW200640916A (en) | 2005-02-21 | 2006-02-20 | (1,5-diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, their preparation and their application in therapeutics |
GT200600082A GT200600082A (es) | 2005-02-21 | 2006-02-20 | Derivados del 2-(1,5-difenil-1h-pirazol-3-il)-1,3,4-oxadiazol, su preparacion y su aplicacion en terapeutica |
PA20068663901A PA8663901A1 (es) | 2005-02-21 | 2006-02-21 | Derivados del (1,5-difenil-1h-pirazol-3-il)oxadiazol, su prepararacion y su aplicacion en terapéutica |
UY29388A UY29388A1 (es) | 2005-02-21 | 2006-02-21 | Derivados del (1,5-difenil-h-pirazol-3-il)oxadiazol, su preparación y su aplicacion en terapéutica. |
SV2006002422A SV2007002422A (es) | 2005-02-21 | 2006-02-21 | Derivados del (1,5-difenil-1h-pirazol-3-il)oxadiazol, su preparacion y su aplicacion en terapeutica. |
ARP060100610A AR055560A1 (es) | 2005-02-21 | 2006-02-21 | Derivados del (1,5-difenil-1h-pirazol-3-il)oxadiazol su preparacion, composicion terapeutica y uso del compuesto para la preparacion de medicamentos |
US11/835,670 US7632852B2 (en) | 2005-02-21 | 2007-08-08 | (1,5-diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics |
IL185163A IL185163A0 (en) | 2005-02-21 | 2007-08-09 | (1,5 - diphenyl - 1h - pyrazol - 3 - yl) oxadiazole derivatives, preparation method thereof and use of same in therapeutics |
MA30157A MA29261B1 (fr) | 2005-02-21 | 2007-08-23 | Derives de (1,5-diphenyl-1h-pyrazol-3-yl)oxadiazole, leur preparation et leur application en therapeutique |
NO20074763A NO20074763L (no) | 2005-02-21 | 2007-09-18 | (1,5-difenyl-1H-pyrazol-3-yl)oksadiazolderivater, fremgangsmate ved fremstilling derav og anvendelse av samme i terapi |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0501860A FR2882365B1 (fr) | 2005-02-21 | 2005-02-21 | Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2882365A1 FR2882365A1 (fr) | 2006-08-25 |
FR2882365B1 true FR2882365B1 (fr) | 2007-09-07 |
Family
ID=35079215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0501860A Expired - Fee Related FR2882365B1 (fr) | 2005-02-21 | 2005-02-21 | Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique |
Country Status (25)
Country | Link |
---|---|
US (1) | US7632852B2 (fr) |
EP (1) | EP1853595A1 (fr) |
JP (1) | JP4812778B2 (fr) |
KR (1) | KR20070107053A (fr) |
CN (1) | CN101119990A (fr) |
AR (1) | AR055560A1 (fr) |
AU (1) | AU2006215443A1 (fr) |
BR (1) | BRPI0606845A2 (fr) |
CA (1) | CA2597359A1 (fr) |
DO (1) | DOP2006000045A (fr) |
EA (1) | EA200701779A1 (fr) |
FR (1) | FR2882365B1 (fr) |
GT (1) | GT200600082A (fr) |
IL (1) | IL185163A0 (fr) |
MA (1) | MA29261B1 (fr) |
MX (1) | MX2007009994A (fr) |
NO (1) | NO20074763L (fr) |
NZ (1) | NZ560790A (fr) |
PA (1) | PA8663901A1 (fr) |
PE (1) | PE20061038A1 (fr) |
SV (1) | SV2007002422A (fr) |
TW (1) | TW200640916A (fr) |
UY (1) | UY29388A1 (fr) |
WO (1) | WO2006087480A1 (fr) |
ZA (1) | ZA200706953B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
KR20090047458A (ko) | 2006-08-08 | 2009-05-12 | 사노피-아벤티스 | 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도 |
US7875647B2 (en) | 2006-09-29 | 2011-01-25 | Green Cross Corporation | Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists |
EP2097410A4 (fr) * | 2006-09-29 | 2009-11-25 | Green Cross Corp | Dérivés d'hétéroaryl-pyrazole utilisés en tant qu'antagonistes du récepteur cb1 des cannabinoïdes |
US20080207704A1 (en) * | 2007-02-27 | 2008-08-28 | The Green Cross Corporation | Heteroaryl-imidazole derivatives as cannabinoid cb1 receptor antagonists |
US7705024B2 (en) | 2007-04-12 | 2010-04-27 | National Health Research Institutes | Oxadiazole compounds |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
WO2009078498A1 (fr) * | 2007-12-17 | 2009-06-25 | Green Cross Corporation | Biarylpyrazole-4-carboxamides comme ligands des récepteurs cannabinoïdes cb1 |
US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
KR101318689B1 (ko) | 2008-09-25 | 2013-10-16 | 주식회사 녹십자 | 칸나비노이드 cb1 수용체 길항제로서 황 함유 피라졸-헤테로사이클 유도체 |
WO2010068601A1 (fr) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant |
RU2012111354A (ru) | 2009-08-26 | 2013-10-10 | Санофи | Новые кристаллические гидраты фторгликозидов, содержащие их фармацевтические препараты и их использование |
EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
WO2012120056A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
EP2683699B1 (fr) | 2011-03-08 | 2015-06-24 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
WO2012120054A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
CN109651350B (zh) * | 2019-01-11 | 2022-05-24 | 贵州大学 | 一类杂环取代的1,3,4-噁(噻)二唑类化合物及其制备方法和用途 |
CN109942567B (zh) * | 2019-04-30 | 2023-04-07 | 贵州大学 | 一种1,3,4-噁(噻)二唑基的咪唑类化合物及其制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09124571A (ja) * | 1995-11-01 | 1997-05-13 | Japan Tobacco Inc | アミド化合物及びその用途 |
FR2758723B1 (fr) * | 1997-01-28 | 1999-04-23 | Sanofi Sa | Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments |
US6825209B2 (en) * | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
WO2004035566A1 (fr) * | 2002-10-18 | 2004-04-29 | Pfizer Products Inc. | Ligands des recepteurs des cannabinoides et applications de ceux-ci |
PL377778A1 (pl) * | 2002-12-02 | 2006-02-20 | Astellas Pharma Inc. | Pochodne pirazolu |
FR2856683A1 (fr) * | 2003-06-25 | 2004-12-31 | Sanofi Synthelabo | Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique |
-
2005
- 2005-02-21 FR FR0501860A patent/FR2882365B1/fr not_active Expired - Fee Related
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2006
- 2006-02-17 CN CNA2006800049844A patent/CN101119990A/zh active Pending
- 2006-02-17 KR KR1020077019014A patent/KR20070107053A/ko not_active Application Discontinuation
- 2006-02-17 EA EA200701779A patent/EA200701779A1/ru unknown
- 2006-02-17 JP JP2007555667A patent/JP4812778B2/ja not_active Expired - Fee Related
- 2006-02-17 BR BRPI0606845-6A patent/BRPI0606845A2/pt not_active IP Right Cessation
- 2006-02-17 ZA ZA200706953A patent/ZA200706953B/xx unknown
- 2006-02-17 WO PCT/FR2006/000368 patent/WO2006087480A1/fr active Application Filing
- 2006-02-17 CA CA002597359A patent/CA2597359A1/fr not_active Abandoned
- 2006-02-17 AU AU2006215443A patent/AU2006215443A1/en not_active Abandoned
- 2006-02-17 NZ NZ560790A patent/NZ560790A/en unknown
- 2006-02-17 PE PE2006000202A patent/PE20061038A1/es not_active Application Discontinuation
- 2006-02-17 EP EP06709338A patent/EP1853595A1/fr not_active Withdrawn
- 2006-02-17 MX MX2007009994A patent/MX2007009994A/es not_active Application Discontinuation
- 2006-02-20 GT GT200600082A patent/GT200600082A/es unknown
- 2006-02-20 DO DO2006000045A patent/DOP2006000045A/es unknown
- 2006-02-20 TW TW095105632A patent/TW200640916A/zh unknown
- 2006-02-21 UY UY29388A patent/UY29388A1/es not_active Application Discontinuation
- 2006-02-21 SV SV2006002422A patent/SV2007002422A/es unknown
- 2006-02-21 PA PA20068663901A patent/PA8663901A1/es unknown
- 2006-02-21 AR ARP060100610A patent/AR055560A1/es unknown
-
2007
- 2007-08-08 US US11/835,670 patent/US7632852B2/en not_active Expired - Fee Related
- 2007-08-09 IL IL185163A patent/IL185163A0/en unknown
- 2007-08-23 MA MA30157A patent/MA29261B1/fr unknown
- 2007-09-18 NO NO20074763A patent/NO20074763L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2007009994A (es) | 2007-10-10 |
PA8663901A1 (es) | 2006-12-07 |
KR20070107053A (ko) | 2007-11-06 |
AU2006215443A1 (en) | 2006-08-24 |
JP2008530188A (ja) | 2008-08-07 |
EP1853595A1 (fr) | 2007-11-14 |
CN101119990A (zh) | 2008-02-06 |
US20080039510A1 (en) | 2008-02-14 |
FR2882365A1 (fr) | 2006-08-25 |
AR055560A1 (es) | 2007-08-22 |
TW200640916A (en) | 2006-12-01 |
GT200600082A (es) | 2006-10-19 |
UY29388A1 (es) | 2006-10-02 |
CA2597359A1 (fr) | 2006-08-24 |
SV2007002422A (es) | 2007-01-17 |
PE20061038A1 (es) | 2006-11-24 |
EA200701779A1 (ru) | 2008-02-28 |
ZA200706953B (en) | 2009-03-25 |
DOP2006000045A (es) | 2006-11-15 |
US7632852B2 (en) | 2009-12-15 |
WO2006087480A1 (fr) | 2006-08-24 |
BRPI0606845A2 (pt) | 2009-07-21 |
NO20074763L (no) | 2007-11-16 |
JP4812778B2 (ja) | 2011-11-09 |
NZ560790A (en) | 2009-08-28 |
IL185163A0 (en) | 2007-12-03 |
MA29261B1 (fr) | 2008-02-01 |
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