ZA200706953B - (1,5-diphenyl-1h-pyrazol-3-yl) oxadiazole derivatives, preparation method thereof and use same in therapeutics - Google Patents

(1,5-diphenyl-1h-pyrazol-3-yl) oxadiazole derivatives, preparation method thereof and use same in therapeutics

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Publication number
ZA200706953B
ZA200706953B ZA200706953A ZA200706953A ZA200706953B ZA 200706953 B ZA200706953 B ZA 200706953B ZA 200706953 A ZA200706953 A ZA 200706953A ZA 200706953 A ZA200706953 A ZA 200706953A ZA 200706953 B ZA200706953 B ZA 200706953B
Authority
ZA
South Africa
Prior art keywords
pyrazol
therapeutics
diphenyl
preparation
use same
Prior art date
Application number
ZA200706953A
Other languages
English (en)
Inventor
Barth Francis
Congy Christian
Gueule Patrick
Rinaldi-Carmona Murielle
Van Broeck Didier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35079215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200706953(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200706953B publication Critical patent/ZA200706953B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
ZA200706953A 2005-02-21 2006-02-17 (1,5-diphenyl-1h-pyrazol-3-yl) oxadiazole derivatives, preparation method thereof and use same in therapeutics ZA200706953B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0501860A FR2882365B1 (fr) 2005-02-21 2005-02-21 Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ZA200706953B true ZA200706953B (en) 2009-03-25

Family

ID=35079215

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200706953A ZA200706953B (en) 2005-02-21 2006-02-17 (1,5-diphenyl-1h-pyrazol-3-yl) oxadiazole derivatives, preparation method thereof and use same in therapeutics

Country Status (25)

Country Link
US (1) US7632852B2 (fr)
EP (1) EP1853595A1 (fr)
JP (1) JP4812778B2 (fr)
KR (1) KR20070107053A (fr)
CN (1) CN101119990A (fr)
AR (1) AR055560A1 (fr)
AU (1) AU2006215443A1 (fr)
BR (1) BRPI0606845A2 (fr)
CA (1) CA2597359A1 (fr)
DO (1) DOP2006000045A (fr)
EA (1) EA200701779A1 (fr)
FR (1) FR2882365B1 (fr)
GT (1) GT200600082A (fr)
IL (1) IL185163A0 (fr)
MA (1) MA29261B1 (fr)
MX (1) MX2007009994A (fr)
NO (1) NO20074763L (fr)
NZ (1) NZ560790A (fr)
PA (1) PA8663901A1 (fr)
PE (1) PE20061038A1 (fr)
SV (1) SV2007002422A (fr)
TW (1) TW200640916A (fr)
UY (1) UY29388A1 (fr)
WO (1) WO2006087480A1 (fr)
ZA (1) ZA200706953B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10361258A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
RU2009108280A (ru) 2006-08-08 2010-09-20 Санофи-Авентис (Fr) Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение
JP5269795B2 (ja) * 2006-09-29 2013-08-21 グリーン・クロス・コーポレイション カンナビノイドｃｂ１受容体アンタゴニストとしてのヘテロアリール−ピラゾール誘導体
US7875647B2 (en) 2006-09-29 2011-01-25 Green Cross Corporation Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists
US20080207704A1 (en) * 2007-02-27 2008-08-28 The Green Cross Corporation Heteroaryl-imidazole derivatives as cannabinoid cb1 receptor antagonists
US7705024B2 (en) 2007-04-12 2010-04-27 National Health Research Institutes Oxadiazole compounds
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
WO2009078498A1 (fr) * 2007-12-17 2009-06-25 Green Cross Corporation Biarylpyrazole-4-carboxamides comme ligands des récepteurs cannabinoïdes cb1
TW201014822A (en) 2008-07-09 2010-04-16 Sanofi Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
US8309584B2 (en) * 2008-09-25 2012-11-13 Green Cross Corporation Sulfur containing pyrazole-heterocycle derivatives as cannabinoid CB1 receptor antagonists
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
JP2013503135A (ja) 2009-08-26 2013-01-31 サノフイ 新規な結晶性複素芳香族フルオログリコシド水和物、その化合物を含んでなる医薬及びその使用
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2766349B1 (fr) 2011-03-08 2016-06-01 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
EP2683700B1 (fr) 2011-03-08 2015-02-18 Sanofi Dérivés d'oxathiazine tétra-substitués, leur procédé de fabrication, leur utilisation comme médicament ainsi que médicaments en étant pourvu et leur utilisation
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
CN109651350B (zh) * 2019-01-11 2022-05-24 贵州大学 一类杂环取代的1,3,4-噁(噻)二唑类化合物及其制备方法和用途
CN109942567B (zh) * 2019-04-30 2023-04-07 贵州大学 一种1,3,4-噁(噻)二唑基的咪唑类化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09124571A (ja) * 1995-11-01 1997-05-13 Japan Tobacco Inc アミド化合物及びその用途
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
US6825209B2 (en) * 2002-04-15 2004-11-30 Research Triangle Institute Compounds having unique CB1 receptor binding selectivity and methods for their production and use
EP1556373A1 (fr) * 2002-10-18 2005-07-27 Pfizer Products Inc. Ligands des recepteurs des cannabinoides et applications de ceux-ci
NZ540515A (en) * 2002-12-02 2008-01-31 Astellas Pharma Inc Pyrazole derivatives useful as COX-I inhibitors
FR2856683A1 (fr) * 2003-06-25 2004-12-31 Sanofi Synthelabo Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JP4812778B2 (ja) 2011-11-09
UY29388A1 (es) 2006-10-02
US20080039510A1 (en) 2008-02-14
EA200701779A1 (ru) 2008-02-28
FR2882365B1 (fr) 2007-09-07
MA29261B1 (fr) 2008-02-01
PA8663901A1 (es) 2006-12-07
EP1853595A1 (fr) 2007-11-14
KR20070107053A (ko) 2007-11-06
CN101119990A (zh) 2008-02-06
FR2882365A1 (fr) 2006-08-25
BRPI0606845A2 (pt) 2009-07-21
GT200600082A (es) 2006-10-19
WO2006087480A1 (fr) 2006-08-24
AR055560A1 (es) 2007-08-22
US7632852B2 (en) 2009-12-15
SV2007002422A (es) 2007-01-17
JP2008530188A (ja) 2008-08-07
TW200640916A (en) 2006-12-01
NZ560790A (en) 2009-08-28
NO20074763L (no) 2007-11-16
AU2006215443A1 (en) 2006-08-24
IL185163A0 (en) 2007-12-03
DOP2006000045A (es) 2006-11-15
MX2007009994A (es) 2007-10-10
CA2597359A1 (fr) 2006-08-24
PE20061038A1 (es) 2006-11-24

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