EP2097410A4 - Dérivés d'hétéroaryl-pyrazole utilisés en tant qu'antagonistes du récepteur cb1 des cannabinoïdes - Google Patents
Dérivés d'hétéroaryl-pyrazole utilisés en tant qu'antagonistes du récepteur cb1 des cannabinoïdesInfo
- Publication number
- EP2097410A4 EP2097410A4 EP07833072A EP07833072A EP2097410A4 EP 2097410 A4 EP2097410 A4 EP 2097410A4 EP 07833072 A EP07833072 A EP 07833072A EP 07833072 A EP07833072 A EP 07833072A EP 2097410 A4 EP2097410 A4 EP 2097410A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cannabinoid
- heteroaryl
- receptor antagonists
- pyrazole derivatives
- pyrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/541,269 US20080081815A1 (en) | 2006-09-29 | 2006-09-29 | Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists |
KR20060132606 | 2006-12-22 | ||
PCT/KR2007/004754 WO2008039023A1 (fr) | 2006-09-29 | 2007-09-28 | Dérivés d'hétéroaryl-pyrazole utilisés en tant qu'antagonistes du récepteur cb1 des cannabinoïdes |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2097410A1 EP2097410A1 (fr) | 2009-09-09 |
EP2097410A4 true EP2097410A4 (fr) | 2009-11-25 |
Family
ID=39234790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07833072A Withdrawn EP2097410A4 (fr) | 2006-09-29 | 2007-09-28 | Dérivés d'hétéroaryl-pyrazole utilisés en tant qu'antagonistes du récepteur cb1 des cannabinoïdes |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2097410A4 (fr) |
JP (1) | JP5269795B2 (fr) |
KR (1) | KR101100028B1 (fr) |
CN (1) | CN101528740B (fr) |
WO (1) | WO2008039023A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
US8426448B2 (en) * | 2008-04-22 | 2013-04-23 | Eli Lilly And Company | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands |
SI2280961T1 (sl) * | 2008-04-22 | 2012-11-30 | Lilly Co Eli | Spojine difenil pirolidin ona kot ligandi cb |
US8916594B2 (en) | 2011-04-27 | 2014-12-23 | Shionogi & Co., Ltd. | 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity |
WO2013005168A2 (fr) * | 2011-07-05 | 2013-01-10 | Lupin Limited | Modulateurs des récepteurs de cannabinoïdes |
JP6543610B2 (ja) | 2013-03-14 | 2019-07-10 | ハンター ダグラス インコーポレイテッド | 建築物開口部のカバーアセンブリを制御する方法および装置 |
WO2015162452A1 (fr) * | 2014-04-23 | 2015-10-29 | Piramal Enterprises Limited | Composés pyrazole substitués comme antagonistes du récepteur cb1 et leurs utilisations |
CN108586436A (zh) * | 2018-07-06 | 2018-09-28 | 南京大学 | 一类含吲哚骨架的双酰肼类衍生物及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100826A2 (fr) * | 2001-06-08 | 2002-12-19 | Cytovia, Inc. | 3-aryl-5-aryl-[1,2,4]-oxadiazoles et leurs analogues, activateurs des caspases et inducteurs de l'apoptose, et leurs utilisations |
US20040077650A1 (en) * | 2002-10-18 | 2004-04-22 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
WO2005018645A1 (fr) * | 2003-08-21 | 2005-03-03 | Pfizer Products Inc. | Composition pharmaceutique pour la prevention et le traitement de l'accoutumance chez un mammifere |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
DE2906252A1 (de) * | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
FR2714057B1 (fr) | 1993-12-17 | 1996-03-08 | Sanofi Elf | Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant. |
TW583000B (en) * | 2000-06-29 | 2004-04-11 | Shionogi & Co | X-type sPLA2 inhibitor as a cancer therapeutical agent |
WO2005032550A2 (fr) | 2002-12-18 | 2005-04-14 | Smithkline Beecham Corporation | Inhibiteurs de la peptide deformylase |
US7605171B2 (en) | 2003-12-17 | 2009-10-20 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
US20080255216A1 (en) * | 2004-03-29 | 2008-10-16 | Aster Susan D | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 |
FR2882365B1 (fr) * | 2005-02-21 | 2007-09-07 | Sanofi Aventis Sa | Derives de 2-(1,5-diphenyl-1h-pyrazol-3-yl)-1,3,4-oxadiazole leur preparation et leur application en therapeutique |
-
2007
- 2007-09-28 EP EP07833072A patent/EP2097410A4/fr not_active Withdrawn
- 2007-09-28 KR KR1020097008743A patent/KR101100028B1/ko active IP Right Grant
- 2007-09-28 CN CN2007800363304A patent/CN101528740B/zh not_active Expired - Fee Related
- 2007-09-28 JP JP2009530273A patent/JP5269795B2/ja not_active Expired - Fee Related
- 2007-09-28 WO PCT/KR2007/004754 patent/WO2008039023A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100826A2 (fr) * | 2001-06-08 | 2002-12-19 | Cytovia, Inc. | 3-aryl-5-aryl-[1,2,4]-oxadiazoles et leurs analogues, activateurs des caspases et inducteurs de l'apoptose, et leurs utilisations |
US20040077650A1 (en) * | 2002-10-18 | 2004-04-22 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
WO2005018645A1 (fr) * | 2003-08-21 | 2005-03-03 | Pfizer Products Inc. | Composition pharmaceutique pour la prevention et le traitement de l'accoutumance chez un mammifere |
Non-Patent Citations (23)
Title |
---|
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE , (3), 917-24 CODEN: BSCFAS; ISSN: 0037-8968, 1971 * |
CHEMISCHE BERICHTE , 90, 2401-4 CODEN: CHBEAM; ISSN: 0009-2940, 1957 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ARRIETA, ANA ET AL: "Efficient tautomerization hydrazone-azomethine imine under microwave irradiation. Synthesis of [4,3'] and [5,3']bipyrazoles", XP002550426, retrieved from STN Database accession no. 1998:678997 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BERGEON, MARIE T. ET AL: "Sulfurated organic compounds. VIII. Reaction of phenylhydrazine with 3-aryl-1,2-dithiolylium bisulfates and 3,5-diaryl-1,2-dithiolylium perchlorates. 3-Aryl-1-phenylpyrazoles, 5-aryl-1-phenylpyrazoles, and 3,5-diaryl-1-phenylpyrazoles", XP002550424, retrieved from STN Database accession no. 1971:420283 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CARRILLO, J. R. ET AL: "A complete model for the prediction of 1H- and 13C-NMR chemical shifts and torsional angles in phenyl-substituted pyrazoles", XP002550430, retrieved from STN Database accession no. 2001:321317 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FINAR, I. L. ET AL: "Preparation of some pyrazole derivatives", XP002550431, retrieved from STN Database accession no. 1959:94763 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FINAR, I. L.: "Preparation and properties of some bipyrazolyls", XP002550425, retrieved from STN Database accession no. 1956:12288 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MASLIVETS, A. N. ET AL: "Five-membered 2,3-dioxo heterocycles. XI. Synthesis and chemical transformations of .beta.-aroylhydrazides of aroylpyruvic acids", XP002550421, retrieved from STN Database accession no. 1990:55776 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MILLER, SIDNEY I. ET AL: "Mass spectra of 1,2,3-triazoles", XP002550429, retrieved from STN Database accession no. 1979:473771 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PFLEGER, ROBERT ET AL: ".alpha.-Acylaminoacrylic acid. VII. The action of hypobromite on .alpha.-acetamidocinnamic acid", XP002550428, retrieved from STN Database accession no. 1958:113664 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIMANSKAYA, N. P. ET AL: "Polarographic study of derivatives of .DELTA.2-pyrazoline", XP002550422, retrieved from STN Database accession no. 1968:512873 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIRONINA, T. M. ET AL: "1,3,4,6-Tetracarbonyl compounds: IV. Reaction of 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine and arylhydrazines", XP002550427, retrieved from STN Database accession no. 2002:136610 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHKUMAT, A. P.: "Search for new luminophores with predetermined physicochemical and chemical properties. I. 1,3,5-Triarylpyrazoles", XP002550423, retrieved from STN Database accession no. 2000:55923 * |
JOURNAL OF THE CHEMICAL SOCIETY 1205-8 CODEN: JCSOA9; ISSN: 0368-1769, 1955 * |
JOURNAL OF THE CHEMICAL SOCIETY 1819-23 CODEN: JCSOA9; ISSN: 0368-1769, 1959 * |
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (1), 15-19 CODEN: JCPRB4; ISSN: 0300-922X, 1979 * |
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (TRANSLATION OF ZHURNAL ORGANICHESKOI KHIMII) , 37(10), 1486-1494 CODEN: RJOCEQ; ISSN: 1070-4280, 2001 * |
See also references of WO2008039023A1 * |
TETRAHEDRON , 54(43), 13167-13180 CODEN: TETRAB; ISSN: 0040-4020, 1998 * |
TETRAHEDRON , 57(19), 4179-4187 CODEN: TETRAB; ISSN: 0040-4020, 2001 * |
VISNIK KHARKIVS'KOGO UNIVERSITETU , (2(CHEM.)), 121-125 CODEN: VKSGA3; ISSN: 0453-8048, 1998 * |
ZHURNAL OBSHCHEI KHIMII , 38(8), 1676-9 CODEN: ZOKHA4; ISSN: 0044-460X, 1968 * |
ZHURNAL ORGANICHESKOI KHIMII , 25(5), 1039-45 CODEN: ZORKAE; ISSN: 0514-7492, 1989 * |
Also Published As
Publication number | Publication date |
---|---|
JP2010504961A (ja) | 2010-02-18 |
JP5269795B2 (ja) | 2013-08-21 |
WO2008039023A1 (fr) | 2008-04-03 |
CN101528740A (zh) | 2009-09-09 |
CN101528740B (zh) | 2012-09-19 |
EP2097410A1 (fr) | 2009-09-09 |
KR20090061076A (ko) | 2009-06-15 |
KR101100028B1 (ko) | 2011-12-29 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 3/04 20060101ALI20091015BHEP Ipc: A61K 31/4155 20060101ALI20091015BHEP Ipc: A61K 31/415 20060101ALI20091015BHEP Ipc: A61P 29/00 20060101ALI20091015BHEP Ipc: C07D 413/04 20060101ALI20091015BHEP Ipc: C07D 419/04 20060101AFI20080428BHEP |
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