EP2097410A4 - Heteroaryl-pyrazole derivatives as cannabinoid cb1 receptor antagonists - Google Patents

Heteroaryl-pyrazole derivatives as cannabinoid cb1 receptor antagonists

Info

Publication number
EP2097410A4
EP2097410A4 EP07833072A EP07833072A EP2097410A4 EP 2097410 A4 EP2097410 A4 EP 2097410A4 EP 07833072 A EP07833072 A EP 07833072A EP 07833072 A EP07833072 A EP 07833072A EP 2097410 A4 EP2097410 A4 EP 2097410A4
Authority
EP
European Patent Office
Prior art keywords
cannabinoid
heteroaryl
receptor antagonists
pyrazole derivatives
pyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07833072A
Other languages
German (de)
French (fr)
Other versions
EP2097410A1 (en
Inventor
Jinhwa Lee
Jeong Min Kim
Chong-Hwan Jonathan Chang
Suk Ho Lee
Hee Jeong Seo
Suk Youn Kang
Kwang-Seop Song
Jong Yup Kim
Min Ju Kim
Sung-Han Lee
Kwang-Woo Ahn
Myung Eun Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GC Biopharma Corp
Original Assignee
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/541,269 external-priority patent/US20080081815A1/en
Application filed by Green Cross Corp Korea filed Critical Green Cross Corp Korea
Publication of EP2097410A1 publication Critical patent/EP2097410A1/en
Publication of EP2097410A4 publication Critical patent/EP2097410A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
EP07833072A 2006-09-29 2007-09-28 Heteroaryl-pyrazole derivatives as cannabinoid cb1 receptor antagonists Withdrawn EP2097410A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/541,269 US20080081815A1 (en) 2006-09-29 2006-09-29 Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists
KR20060132606 2006-12-22
PCT/KR2007/004754 WO2008039023A1 (en) 2006-09-29 2007-09-28 Heteroaryl-pyrazole derivatives as cannabinoid cb1 receptor antagonists

Publications (2)

Publication Number Publication Date
EP2097410A1 EP2097410A1 (en) 2009-09-09
EP2097410A4 true EP2097410A4 (en) 2009-11-25

Family

ID=39234790

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07833072A Withdrawn EP2097410A4 (en) 2006-09-29 2007-09-28 Heteroaryl-pyrazole derivatives as cannabinoid cb1 receptor antagonists

Country Status (5)

Country Link
EP (1) EP2097410A4 (en)
JP (1) JP5269795B2 (en)
KR (1) KR101100028B1 (en)
CN (1) CN101528740B (en)
WO (1) WO2008039023A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
CN102119029B (en) * 2008-04-22 2013-03-13 伊莱利利公司 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands
BRPI0910775A2 (en) * 2008-04-22 2015-09-29 Lilly Co Eli 1,5-diphenyl pyrrolidin-2-one compounds as cb-1 ligands
ES2639940T3 (en) * 2011-04-27 2017-10-30 Shionogi & Co., Ltd. 5-membered aromatic heterocyclic ring derivative that has NPY Y5 receptor antagonist activity
WO2013005168A2 (en) * 2011-07-05 2013-01-10 Lupin Limited Cannabinoid receptor modulators
AR095498A1 (en) 2013-03-14 2015-10-21 Hunter Douglas METHODS AND APPLIANCES TO CONTROL A COVERAGE PROVISION FOR ARCHITECTURAL OPENINGS
WO2015162452A1 (en) * 2014-04-23 2015-10-29 Piramal Enterprises Limited Substituted pyrazole compounds as cb1 receptor antagonists and uses thereof
CN108586436A (en) * 2018-07-06 2018-09-28 南京大学 Bishydrazide derivative of one kind skeleton containing indoles and its preparation method and application

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2002100826A2 (en) * 2001-06-08 2002-12-19 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs
US20040077650A1 (en) * 2002-10-18 2004-04-22 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
WO2005018645A1 (en) * 2003-08-21 2005-03-03 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of addiction in a mammal

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US4146721A (en) * 1969-09-12 1979-03-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrazol-4-acetic acid compounds
DE2906252A1 (en) * 1979-02-19 1980-08-28 Merck Patent Gmbh PYRAZOLE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2714057B1 (en) 1993-12-17 1996-03-08 Sanofi Elf New derivatives of 3-pyrazolecarboxamide, process for their preparation and pharmaceutical compositions containing them.
US20040077651A1 (en) * 2000-06-29 2004-04-22 Kohji Hanasaki Remedies for cancer
ATE548037T1 (en) 2002-12-18 2012-03-15 Glaxosmithkline Llc PEPTIDE DEFORMYLASE INHIBITORS
WO2005058848A1 (en) 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
CN1938286A (en) * 2004-03-29 2007-03-28 默克公司 Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
FR2882365B1 (en) * 2005-02-21 2007-09-07 Sanofi Aventis Sa 2- (1,5-DIPHENYL-1H-PYRAZOL-3-YL) -1,3,4-OXADIAZOLE DERIVATIVES AND THEIR PREPARATION AND THERAPEUTIC USE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100826A2 (en) * 2001-06-08 2002-12-19 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs
US20040077650A1 (en) * 2002-10-18 2004-04-22 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
WO2005018645A1 (en) * 2003-08-21 2005-03-03 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of addiction in a mammal

Non-Patent Citations (23)

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Title
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE , (3), 917-24 CODEN: BSCFAS; ISSN: 0037-8968, 1971 *
CHEMISCHE BERICHTE , 90, 2401-4 CODEN: CHBEAM; ISSN: 0009-2940, 1957 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ARRIETA, ANA ET AL: "Efficient tautomerization hydrazone-azomethine imine under microwave irradiation. Synthesis of [4,3'] and [5,3']bipyrazoles", XP002550426, retrieved from STN Database accession no. 1998:678997 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BERGEON, MARIE T. ET AL: "Sulfurated organic compounds. VIII. Reaction of phenylhydrazine with 3-aryl-1,2-dithiolylium bisulfates and 3,5-diaryl-1,2-dithiolylium perchlorates. 3-Aryl-1-phenylpyrazoles, 5-aryl-1-phenylpyrazoles, and 3,5-diaryl-1-phenylpyrazoles", XP002550424, retrieved from STN Database accession no. 1971:420283 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CARRILLO, J. R. ET AL: "A complete model for the prediction of 1H- and 13C-NMR chemical shifts and torsional angles in phenyl-substituted pyrazoles", XP002550430, retrieved from STN Database accession no. 2001:321317 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FINAR, I. L. ET AL: "Preparation of some pyrazole derivatives", XP002550431, retrieved from STN Database accession no. 1959:94763 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FINAR, I. L.: "Preparation and properties of some bipyrazolyls", XP002550425, retrieved from STN Database accession no. 1956:12288 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MASLIVETS, A. N. ET AL: "Five-membered 2,3-dioxo heterocycles. XI. Synthesis and chemical transformations of .beta.-aroylhydrazides of aroylpyruvic acids", XP002550421, retrieved from STN Database accession no. 1990:55776 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MILLER, SIDNEY I. ET AL: "Mass spectra of 1,2,3-triazoles", XP002550429, retrieved from STN Database accession no. 1979:473771 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PFLEGER, ROBERT ET AL: ".alpha.-Acylaminoacrylic acid. VII. The action of hypobromite on .alpha.-acetamidocinnamic acid", XP002550428, retrieved from STN Database accession no. 1958:113664 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIMANSKAYA, N. P. ET AL: "Polarographic study of derivatives of .DELTA.2-pyrazoline", XP002550422, retrieved from STN Database accession no. 1968:512873 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHIRONINA, T. M. ET AL: "1,3,4,6-Tetracarbonyl compounds: IV. Reaction of 3,4-dihydroxy-2,4-hexadiene-1,6-diones with hydrazine and arylhydrazines", XP002550427, retrieved from STN Database accession no. 2002:136610 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHKUMAT, A. P.: "Search for new luminophores with predetermined physicochemical and chemical properties. I. 1,3,5-Triarylpyrazoles", XP002550423, retrieved from STN Database accession no. 2000:55923 *
JOURNAL OF THE CHEMICAL SOCIETY 1205-8 CODEN: JCSOA9; ISSN: 0368-1769, 1955 *
JOURNAL OF THE CHEMICAL SOCIETY 1819-23 CODEN: JCSOA9; ISSN: 0368-1769, 1959 *
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (1), 15-19 CODEN: JCPRB4; ISSN: 0300-922X, 1979 *
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (TRANSLATION OF ZHURNAL ORGANICHESKOI KHIMII) , 37(10), 1486-1494 CODEN: RJOCEQ; ISSN: 1070-4280, 2001 *
See also references of WO2008039023A1 *
TETRAHEDRON , 54(43), 13167-13180 CODEN: TETRAB; ISSN: 0040-4020, 1998 *
TETRAHEDRON , 57(19), 4179-4187 CODEN: TETRAB; ISSN: 0040-4020, 2001 *
VISNIK KHARKIVS'KOGO UNIVERSITETU , (2(CHEM.)), 121-125 CODEN: VKSGA3; ISSN: 0453-8048, 1998 *
ZHURNAL OBSHCHEI KHIMII , 38(8), 1676-9 CODEN: ZOKHA4; ISSN: 0044-460X, 1968 *
ZHURNAL ORGANICHESKOI KHIMII , 25(5), 1039-45 CODEN: ZORKAE; ISSN: 0514-7492, 1989 *

Also Published As

Publication number Publication date
CN101528740A (en) 2009-09-09
CN101528740B (en) 2012-09-19
EP2097410A1 (en) 2009-09-09
JP5269795B2 (en) 2013-08-21
KR20090061076A (en) 2009-06-15
KR101100028B1 (en) 2011-12-29
WO2008039023A1 (en) 2008-04-03
JP2010504961A (en) 2010-02-18

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