CO5540344A2 - Medicamentos - Google Patents
MedicamentosInfo
- Publication number
- CO5540344A2 CO5540344A2 CO03101671A CO03101671A CO5540344A2 CO 5540344 A2 CO5540344 A2 CO 5540344A2 CO 03101671 A CO03101671 A CO 03101671A CO 03101671 A CO03101671 A CO 03101671A CO 5540344 A2 CO5540344 A2 CO 5540344A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- optionally substituted
- alkenyl
- hydroxy
- sulfonyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Un compuesto de fórmula (I) o un derivado del mismo farmacéuticamente aceptable: en donde:uno de Z1, Z2, Z3, Z4 y Z5 es N, uno es CR1a y el resto son CH, o uno de Z1, Z2, Z3, Z4 y Z5 es CR1a y el resto son CH;Rv y Rw son hidrógeno o Rv y Rw juntos son un enlace;R1 y R1a se seleccionan independientemente del grupo formado por hidrógeno; hidroxi; alcoxi (C1-6) opcionalmente sustituido con alcoxi (C1-6), amino, piperidilo, guanidino o amidino cualquiera de los cuales está opcionalmente N-sustituido con uno o dos grupos alquilo (C1-6), acilo o alquil(C1-6)sulfonilo, CONH2, hidroxi, alquil(C1-6)tio, heterocicliltio, heterocicliloxi, ariltio, ariloxi, aciltio, aciloxi o alquil(C1-6)sulfoniloxi;alquilo (C1-6) sustituido con alcoxi (C1-6); halógeno; alquilo (C1-6); alquil(C1-6)tio;trifluorometilo; nitro; azido; acilo; aciloxi; aciltio; alquil(C1-6)sulfonilo;alquil(C1-6)sulfóxido; arilsulfonilo; arilsulfóxido o un grupo amino, piperidilo, guanidino o amidino opcionalmente N-sustituido con uno o dos grupos alquilo (C1-6), acilo o alquil(C1-6)sulfonilo, o cuando Z1 es CR1a, R1 y R1a juntos pueden representar alquilen(C1-2)dioxi,con la condición de que, cuando Z1, Z2, Z3, Z4 y Z5 son CR1a o CH, entonces R1 no sea hidrógeno;R2 es hidrógeno, o alquilo (C1-4) o alquenilo (C2-4) opcionalmente sustituido con 1 a 3 grupos seleccionados entre:amino opcionalmente sustituido con uno o dos alquilo (C1-4) grupos; carboxi; alcoxi (C1-4) carbonilo; alquil (C1-4) carbonilo; alquenil (C2-4) oxicarbonilo; alquenil (C2-4) carbonilo; aminocarbonilo en donde el grupo amino está opcionalmente sustituido con hidroxi, alquilo (C1-4), hidroxialquilo (C1-4), aminocarbonilo-alquilo (C1-4), alquenilo(C2-4), alquil (C1-4) sulfonilo, trifluorometilsulfonilo, alquenil (C2-4) sulfonilo, alcoxi (C1-4) carbonilo, alquil (C1-4) carbonilo, alquenil (C2-4) oxicarbonilo o alquenil (C2-4) carbonilo; ciano; tetrazolilo; 2-oxo-oxazolidinilo opcionalmente sustituido con R10; 3-hidroxi-3-ciclobuteno-1,2-diona-4-ilo; 2,4-tiazolidinadiona-5-ilo; tetrazol-5-ilaminocarbonilo; 1,2,4-triazol-5-ilo opcionalmente sustituido con R10; 5-oxo-1,2,4-oxadiazol-3-ilo; halógeno; alquil (C1-4) tio; trifluorometilo; hidroxi opcionalmente sustituido con alquilo (C1-4), ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0112834.7A GB0112834D0 (en) | 2001-05-25 | 2001-05-25 | Medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5540344A2 true CO5540344A2 (es) | 2005-07-29 |
Family
ID=9915342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO03101671A CO5540344A2 (es) | 2001-05-25 | 2003-11-18 | Medicamentos |
Country Status (23)
Country | Link |
---|---|
US (2) | US7141564B2 (es) |
EP (1) | EP1399443B1 (es) |
JP (2) | JP4463565B2 (es) |
KR (1) | KR20040010654A (es) |
CN (1) | CN1535272A (es) |
AR (1) | AR038172A1 (es) |
AT (1) | ATE380812T1 (es) |
AU (1) | AU2002367697A1 (es) |
BR (1) | BR0210016A (es) |
CA (1) | CA2448525A1 (es) |
CO (1) | CO5540344A2 (es) |
CZ (1) | CZ20033202A3 (es) |
DE (1) | DE60224039T2 (es) |
ES (1) | ES2298439T3 (es) |
GB (1) | GB0112834D0 (es) |
HU (1) | HUP0400017A2 (es) |
IL (1) | IL158869A0 (es) |
MX (1) | MXPA03010790A (es) |
NO (1) | NO20035190D0 (es) |
PL (1) | PL367079A1 (es) |
TW (1) | TWI232219B (es) |
WO (1) | WO2003087098A1 (es) |
ZA (1) | ZA200308696B (es) |
Families Citing this family (72)
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SE9703377D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
BR0112750A (pt) | 2000-07-26 | 2003-09-09 | Smithkline Beecham Plc | Aminopiperidina quinolinas e seus análogos azaisostéricos com atividade antibacteriana |
DE60119939T2 (de) * | 2000-09-21 | 2006-11-30 | Smithkline Beecham P.L.C., Brentford | Chinolinderivate als antibakterielle mittel |
GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0112836D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
TW200406410A (en) * | 2002-01-29 | 2004-05-01 | Glaxo Group Ltd | Compounds |
AU2003239302A1 (en) | 2002-01-29 | 2003-09-02 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
AR040335A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
TW200409637A (en) * | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
DE60334016D1 (de) | 2002-11-05 | 2010-10-14 | Glaxo Group Ltd | Antibakterielle mittel |
EP1560821B8 (en) * | 2002-11-05 | 2010-05-19 | Glaxo Group Limited | Antibacterial agents |
AU2003294565A1 (en) | 2002-12-04 | 2004-06-23 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
EP1569647B1 (en) | 2002-12-13 | 2008-08-20 | Smithkline Beecham Corporation | Cyclohexyl compounds as ccr5 antagonists |
AR042486A1 (es) * | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004041163A1 (de) * | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
JP2008528587A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
US7511035B2 (en) | 2005-01-25 | 2009-03-31 | Glaxo Group Limited | Antibacterial agents |
JP2008528598A (ja) * | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008528588A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
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TWI429643B (zh) | 2008-02-22 | 2014-03-11 | Actelion Pharmaceuticals Ltd | 唑啶酮衍生物 |
JP2011518149A (ja) | 2008-04-15 | 2011-06-23 | アクテリオン ファーマシューティカルズ リミテッド | 三環式抗菌剤 |
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JP5653935B2 (ja) | 2009-01-15 | 2015-01-14 | グラクソ グループ リミテッドGlaxo Group Limited | 抗菌薬として有用なナフチリジン―2(1h)−オン化合物 |
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EP2980090A4 (en) * | 2013-03-29 | 2016-11-09 | Daiichi Sankyo Co Ltd | PROCESS FOR THE PREPARATION OF (1S, 4S, 5S -4-BROM-6-OXABICYCLO [3.2.1] OCTAN-7-ON |
JP6440690B2 (ja) | 2013-05-13 | 2018-12-19 | シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドShanghai Hengrui Pharmaceutical Co., Ltd. | シクロアルキル酸誘導体、その製造方法、およびその医薬適用 |
AR101674A1 (es) | 2014-08-22 | 2017-01-04 | Glaxosmithkline Ip Dev Ltd | Uso de un compuesto tricíclico que contiene nitrógeno |
KR102026342B1 (ko) | 2014-10-24 | 2019-09-27 | 란도스 바이오파마, 인크. | 란티오닌 합성효소 c-유사 2-계 치료제 |
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US11884647B2 (en) | 2019-10-18 | 2024-01-30 | The Regents Of The University Of California | Compounds and methods for targeting pathogenic blood vessels |
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-
2001
- 2001-05-25 GB GBGB0112834.7A patent/GB0112834D0/en not_active Ceased
-
2002
- 2002-05-23 AR ARP020101914A patent/AR038172A1/es not_active Application Discontinuation
- 2002-05-23 TW TW091110839A patent/TWI232219B/zh not_active IP Right Cessation
- 2002-05-24 EP EP02807202A patent/EP1399443B1/en not_active Expired - Lifetime
- 2002-05-24 CA CA002448525A patent/CA2448525A1/en not_active Abandoned
- 2002-05-24 MX MXPA03010790A patent/MXPA03010790A/es unknown
- 2002-05-24 KR KR10-2003-7015379A patent/KR20040010654A/ko not_active Application Discontinuation
- 2002-05-24 CN CNA028146689A patent/CN1535272A/zh active Pending
- 2002-05-24 JP JP2003584054A patent/JP4463565B2/ja not_active Expired - Fee Related
- 2002-05-24 AU AU2002367697A patent/AU2002367697A1/en not_active Abandoned
- 2002-05-24 HU HU0400017A patent/HUP0400017A2/hu unknown
- 2002-05-24 AT AT02807202T patent/ATE380812T1/de not_active IP Right Cessation
- 2002-05-24 US US10/478,154 patent/US7141564B2/en not_active Expired - Fee Related
- 2002-05-24 WO PCT/EP2002/005708 patent/WO2003087098A1/en active IP Right Grant
- 2002-05-24 DE DE60224039T patent/DE60224039T2/de not_active Expired - Lifetime
- 2002-05-24 ES ES02807202T patent/ES2298439T3/es not_active Expired - Lifetime
- 2002-05-24 CZ CZ20033202A patent/CZ20033202A3/cs unknown
- 2002-05-24 BR BR0210016-9A patent/BR0210016A/pt not_active IP Right Cessation
- 2002-05-24 PL PL02367079A patent/PL367079A1/xx not_active Application Discontinuation
- 2002-05-24 IL IL15886902A patent/IL158869A0/xx unknown
-
2003
- 2003-11-07 ZA ZA200308696A patent/ZA200308696B/en unknown
- 2003-11-18 CO CO03101671A patent/CO5540344A2/es not_active Application Discontinuation
- 2003-11-21 NO NO20035190A patent/NO20035190D0/no not_active Application Discontinuation
-
2006
- 2006-11-22 US US11/604,045 patent/US20070135422A1/en not_active Abandoned
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2009
- 2009-11-13 JP JP2009259981A patent/JP2010031057A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2298439T3 (es) | 2008-05-16 |
JP2010031057A (ja) | 2010-02-12 |
US7141564B2 (en) | 2006-11-28 |
BR0210016A (pt) | 2004-06-15 |
DE60224039T2 (de) | 2008-11-27 |
ATE380812T1 (de) | 2007-12-15 |
TWI232219B (en) | 2005-05-11 |
EP1399443A1 (en) | 2004-03-24 |
CN1535272A (zh) | 2004-10-06 |
KR20040010654A (ko) | 2004-01-31 |
US20040171620A1 (en) | 2004-09-02 |
JP2005519981A (ja) | 2005-07-07 |
JP4463565B2 (ja) | 2010-05-19 |
MXPA03010790A (es) | 2004-03-02 |
PL367079A1 (en) | 2005-02-21 |
CZ20033202A3 (cs) | 2004-08-18 |
HUP0400017A2 (hu) | 2004-06-28 |
AU2002367697A1 (en) | 2003-10-27 |
AR038172A1 (es) | 2005-01-05 |
DE60224039D1 (de) | 2008-01-24 |
NO20035190D0 (no) | 2003-11-21 |
GB0112834D0 (en) | 2001-07-18 |
US20070135422A1 (en) | 2007-06-14 |
CA2448525A1 (en) | 2003-10-23 |
WO2003087098A1 (en) | 2003-10-23 |
ZA200308696B (en) | 2004-05-21 |
IL158869A0 (en) | 2004-05-12 |
EP1399443B1 (en) | 2007-12-12 |
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