PE20040071A1 - Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion - Google Patents

Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Info

Publication number
PE20040071A1
PE20040071A1 PE2003000232A PE2003000232A PE20040071A1 PE 20040071 A1 PE20040071 A1 PE 20040071A1 PE 2003000232 A PE2003000232 A PE 2003000232A PE 2003000232 A PE2003000232 A PE 2003000232A PE 20040071 A1 PE20040071 A1 PE 20040071A1
Authority
PE
Peru
Prior art keywords
indazol
chloro
compositions containing
manufacturing procedure
substituted indazoles
Prior art date
Application number
PE2003000232A
Other languages
English (en)
Inventor
Dominique Damour
Corinne Terrier
Patrick Nemecek
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PE20040071A1 publication Critical patent/PE20040071A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

SE REFIERE A INDAZOLES DE FORMULA I DONDE R1 ES H, HALO, ALQUILO, ALQUILENO, ALQUINILO, ARILO, HETEROARILO, CICLOALQUILO, HETEROCICLILO, ALQUILO SUSTITUIDO CON ALQUILENO, ENTRE OTROS; X ES S(O2)-NH, S(O2)-O, NH-S(O2), O-S(O2); Z ES ALQUILO, ARILO, HETEROARILO, CICLOALQUILO, HETEROCICLILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-(3-CLORO-1H-INDAZOL-5-IL)-2-METILSULFONILBENCENOSULFONAMIDA, N-(3-CLORO-1H-INDAZOL-5-IL)-3,4-DICLOROBENCENOSULFONAMIDA, N-(3-CLORO-1H-INDAZOL-5-IL)-3-FLUORBENCENOSULFONAMIDA, N-(3-CIANO-1H-INDAZOL-5-IL)-3-FLUORBENCENOSULFONAMIDA, 3,4-DICLORO-N-(3-FENIL-1H-INDAZOL-5-IL)-BENCENOSULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS PRESENTAN ACTIVIDAD INHIBIDORA DE LAS CINASAS POR LO QUE SON UTILES COMO ANTICANCERIGENOS
PE2003000232A 2002-03-11 2003-03-07 Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion PE20040071A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
PE20040071A1 true PE20040071A1 (es) 2004-02-13

Family

ID=27763684

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000232A PE20040071A1 (es) 2002-03-11 2003-03-07 Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Country Status (29)

Country Link
US (2) US6858638B2 (es)
EP (1) EP1487803A1 (es)
JP (1) JP4643910B2 (es)
KR (1) KR20040091128A (es)
CN (1) CN100369899C (es)
AR (1) AR038914A1 (es)
AU (1) AU2003242808B2 (es)
BR (1) BR0308339A (es)
CA (1) CA2478540A1 (es)
EC (1) ECSP045286A (es)
FR (1) FR2836914B1 (es)
GT (1) GT200300031A (es)
HN (1) HN2003000094A (es)
HR (1) HRP20040825A2 (es)
IL (2) IL163805A0 (es)
MA (1) MA27176A1 (es)
MX (1) MXPA04008446A (es)
NO (1) NO20044261L (es)
OA (1) OA12784A (es)
PA (1) PA8566701A1 (es)
PE (1) PE20040071A1 (es)
PL (1) PL372389A1 (es)
RU (1) RU2004130280A (es)
SV (1) SV2003001493A (es)
TN (1) TNSN04175A1 (es)
TW (1) TW200303863A (es)
UY (1) UY27712A1 (es)
WO (1) WO2003078402A1 (es)
ZA (1) ZA200406730B (es)

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WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
BR112013009093B1 (pt) 2010-10-29 2022-04-19 Abbvie Inc Processo para a preparação de uma dispersão sólida contendo um agente indutor de apoptose
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
RU2593231C2 (ru) 2010-11-23 2016-08-10 ЭббВи Айэленд Анлимитед Компани Способы лечения с использованием селективных ингибиторов bcl-2
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Also Published As

Publication number Publication date
AU2003242808B2 (en) 2008-09-18
WO2003078402A1 (fr) 2003-09-25
CN1642922A (zh) 2005-07-20
US20040106667A1 (en) 2004-06-03
SV2003001493A (es) 2003-07-10
TW200303863A (en) 2003-09-16
UY27712A1 (es) 2003-09-30
IL163805A (en) 2009-08-03
KR20040091128A (ko) 2004-10-27
ZA200406730B (en) 2005-08-24
NO20044261L (no) 2004-11-25
JP2005533004A (ja) 2005-11-04
EP1487803A1 (fr) 2004-12-22
BR0308339A (pt) 2005-02-01
US20050059722A1 (en) 2005-03-17
JP4643910B2 (ja) 2011-03-02
TNSN04175A1 (fr) 2007-03-12
US7473701B2 (en) 2009-01-06
ECSP045286A (es) 2004-10-26
AU2003242808A1 (en) 2003-09-29
PL372389A1 (en) 2005-07-25
GT200300031A (es) 2006-05-26
HRP20040825A2 (en) 2005-06-30
MXPA04008446A (es) 2004-12-06
HN2003000094A (es) 2003-12-15
US6858638B2 (en) 2005-02-22
IL163805A0 (en) 2005-12-18
FR2836914B1 (fr) 2008-03-14
MA27176A1 (fr) 2005-01-03
PA8566701A1 (es) 2003-12-10
CA2478540A1 (fr) 2003-09-25
OA12784A (fr) 2006-07-10
AR038914A1 (es) 2005-02-02
FR2836914A1 (fr) 2003-09-12
RU2004130280A (ru) 2005-06-27
CN100369899C (zh) 2008-02-20

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