ECSP045286A - Indazoles sustituidos con una actividad anticancerosa - Google Patents

Indazoles sustituidos con una actividad anticancerosa

Info

Publication number
ECSP045286A
ECSP045286A EC2004005286A ECSP045286A ECSP045286A EC SP045286 A ECSP045286 A EC SP045286A EC 2004005286 A EC2004005286 A EC 2004005286A EC SP045286 A ECSP045286 A EC SP045286A EC SP045286 A ECSP045286 A EC SP045286A
Authority
EC
Ecuador
Prior art keywords
indazols
replaced
target activity
substituted indazoles
activity
Prior art date
Application number
EC2004005286A
Other languages
English (en)
Inventor
Dominique Damour
Jean-Christophe Carry
Patrick Nemecek
Corinne Terrier
Frederico Nardi
Bruno Filoche
Marie-Pierre Cherrier
Daniel Bezard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of ECSP045286A publication Critical patent/ECSP045286A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)

Abstract

Indazoles sustituidos, composiciones que los contienen, procedimiento de fabricación y uso. La presente invención se refiere en particular a nuevos indazoles sustituidos específicos que presentan una actividad inhibidora de quinasas, que tienen una actividad terapéutica, en particular en oncología.
EC2004005286A 2002-03-11 2004-09-10 Indazoles sustituidos con una actividad anticancerosa ECSP045286A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
ECSP045286A true ECSP045286A (es) 2004-10-26

Family

ID=27763684

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005286A ECSP045286A (es) 2002-03-11 2004-09-10 Indazoles sustituidos con una actividad anticancerosa

Country Status (29)

Country Link
US (2) US6858638B2 (es)
EP (1) EP1487803A1 (es)
JP (1) JP4643910B2 (es)
KR (1) KR20040091128A (es)
CN (1) CN100369899C (es)
AR (1) AR038914A1 (es)
AU (1) AU2003242808B2 (es)
BR (1) BR0308339A (es)
CA (1) CA2478540A1 (es)
EC (1) ECSP045286A (es)
FR (1) FR2836914B1 (es)
GT (1) GT200300031A (es)
HN (1) HN2003000094A (es)
HR (1) HRP20040825A2 (es)
IL (2) IL163805A0 (es)
MA (1) MA27176A1 (es)
MX (1) MXPA04008446A (es)
NO (1) NO20044261L (es)
OA (1) OA12784A (es)
PA (1) PA8566701A1 (es)
PE (1) PE20040071A1 (es)
PL (1) PL372389A1 (es)
RU (1) RU2004130280A (es)
SV (1) SV2003001493A (es)
TN (1) TNSN04175A1 (es)
TW (1) TW200303863A (es)
UY (1) UY27712A1 (es)
WO (1) WO2003078402A1 (es)
ZA (1) ZA200406730B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
GB0218625D0 (en) * 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
WO2004037814A1 (en) * 2002-10-25 2004-05-06 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
WO2005014554A1 (en) * 2003-08-08 2005-02-17 Astex Therapeutics Limited 1h-indazole-3-carboxamide compounds as mapkap kinase modulators
FR2864084B1 (fr) * 2003-12-17 2006-02-10 Aventis Pharma Sa Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
EP1763524A1 (en) * 2004-04-23 2007-03-21 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
US7550598B2 (en) 2004-08-18 2009-06-23 Takeda Pharmaceutical Company Limited Kinase inhibitors
DK1797042T3 (da) * 2004-09-29 2009-03-02 Hoffmann La Roche Indozolonderivater som 11B-HSD1-inhibitorer
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
AU2006283944A1 (en) * 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 MAP kinase inhibitors and methods for using the same
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
DK1981851T3 (da) 2006-01-31 2012-03-19 Array Biopharma Inc Kinaseinhibitorer og fremgangsmåder til anvendelse deraf
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG175609A1 (en) 2006-10-09 2011-11-28 Takeda Pharmaceutical Kinase inhibitors
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
CA2690619A1 (en) 2007-07-16 2009-01-22 Abbott Laboratories Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
KR102001418B1 (ko) 2009-05-26 2019-07-19 애브비 아일랜드 언리미티드 컴퍼니 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
CA2811805A1 (en) 2010-10-29 2012-05-03 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
RU2628560C2 (ru) 2010-11-23 2017-08-18 Эббви Инк. Соли и кристаллические формы индуцирующего апоптоз агента
EP2642999B1 (en) 2010-11-23 2016-09-28 AbbVie Bahamas Ltd. Methods of treatment using selective bcl-2 inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2965741C (en) 2014-11-03 2022-05-17 Iomet Pharma Ltd Pharmaceutical compound
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
WO2019018853A1 (en) * 2017-07-21 2019-01-24 Kadmon Corporation, Llc INHIBITORS OF PROTEIN KINASE CONTAINING RHO-ASSOCIATED ROLL COIL
EP3676255B1 (en) 2017-08-29 2025-04-16 Rutgers, The State University University Of New Jersey Therapeutic indazoles
KR20240056718A (ko) 2021-08-10 2024-04-30 아이에프엠 듀, 인크. Sting 활성과 연합된 상태를 치료하기 위한 화합물 및 조성물
JP2025504415A (ja) * 2022-01-12 2025-02-12 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する病態を治療するための化合物及び組成物
CN116693519A (zh) 2022-03-04 2023-09-05 上海璎黎药业有限公司 一种含五元杂芳环结构化合物、其药物组合物及应用
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途
JP2026502949A (ja) 2022-12-30 2026-01-27 アヴィセンナ バイオサイエンシズ インコーポレイテッド アザインドールｒｏｃｋ阻害剤
TW202540125A (zh) * 2023-11-28 2025-10-16 美商匡特Ｘ生物科技美國股份有限公司 雙環雜芳基化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS514505Y2 (es) 1971-02-13 1976-02-07
JPH061350B2 (ja) * 1985-07-26 1994-01-05 コニカ株式会社 ハロゲン化銀写真感光材料
ATE249213T1 (de) 1996-02-22 2003-09-15 Tularik Inc Pentafluorobenzensulfonamiden und analoge
IL127965A0 (en) * 1996-07-19 1999-11-30 Tularik Inc Pentafluorobenzenesulfonamide derivatives analogs thereof and pharmaceutical compositions containing the same
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
AU1818400A (en) 1998-11-12 2000-05-29 Eli Lilly And Company Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
CO5170498A1 (es) * 1999-05-28 2002-06-27 Abbott Lab Biaril sulfonamidas son utiles como inhibidores de proliferacion celular
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
KR100423899B1 (ko) * 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
CA2440842A1 (en) 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
JPWO2002100833A1 (ja) 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
US7064215B2 (en) * 2001-07-03 2006-06-20 Chiron Corporation Indazole benzimidazole compounds
WO2003024969A1 (en) 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2836915B1 (fr) * 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
FR2836914A1 (fr) 2003-09-12
AU2003242808A1 (en) 2003-09-29
BR0308339A (pt) 2005-02-01
SV2003001493A (es) 2003-07-10
KR20040091128A (ko) 2004-10-27
US20050059722A1 (en) 2005-03-17
US6858638B2 (en) 2005-02-22
IL163805A0 (en) 2005-12-18
GT200300031A (es) 2006-05-26
JP2005533004A (ja) 2005-11-04
PL372389A1 (en) 2005-07-25
FR2836914B1 (fr) 2008-03-14
MXPA04008446A (es) 2004-12-06
HN2003000094A (es) 2003-12-15
IL163805A (en) 2009-08-03
AR038914A1 (es) 2005-02-02
US7473701B2 (en) 2009-01-06
TW200303863A (en) 2003-09-16
RU2004130280A (ru) 2005-06-27
ZA200406730B (en) 2005-08-24
HRP20040825A2 (en) 2005-06-30
UY27712A1 (es) 2003-09-30
CA2478540A1 (fr) 2003-09-25
WO2003078402A1 (fr) 2003-09-25
JP4643910B2 (ja) 2011-03-02
MA27176A1 (fr) 2005-01-03
CN100369899C (zh) 2008-02-20
PA8566701A1 (es) 2003-12-10
NO20044261L (no) 2004-11-25
OA12784A (fr) 2006-07-10
PE20040071A1 (es) 2004-02-13
CN1642922A (zh) 2005-07-20
EP1487803A1 (fr) 2004-12-22
US20040106667A1 (en) 2004-06-03
TNSN04175A1 (fr) 2007-03-12
AU2003242808B2 (en) 2008-09-18

Similar Documents

Publication Publication Date Title
ECSP045286A (es) Indazoles sustituidos con una actividad anticancerosa
UY28941A1 (es) Indazoles sustituidos, composiciones que los contienen, procedimiento de preparacion y su uso
UY27729A1 (es) Inhibidores de quinasas.
ECSP024382A (es) Inhibidores de proteasa de serina
BRPI0616630B8 (pt) compostos de pirazol substituídos
DE50306232D1 (de) Ampholytisches copolymer und dessen verwendung
DE602004026113D1 (de) Glp-1-verbindungen
NO20071078L (no) Antivirale forbindelser
NO20070866L (no) Antivirale forbindelser.
UY28514A1 (es) Nuevos compuestos
CR9846A (es) 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas
ATE430747T1 (de) 2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren
AR035293A1 (es) Composicion oftalmica.
ITMI20031570A1 (it) Composizione per uso dietetico, farmaceutico o cosmetico
DK1641803T3 (da) Thienopyrimidinderivater som kaliumkanalinhibitorer
UY28350A1 (es) Productos aril-heteroaromaticos, composiciones que los contienen y su utilización
DK1596870T4 (da) Højdosis-ibandronatformulering
ATE397007T1 (de) Avermectin b1-derivate die einen aminosulfonyloxy substituenten in der 4-stellung enthalten
NO20071613L (no) Forbindelser for myokardial perfusjons-billeddannelse
SV2008002856A (es) 2-amino-7, 8-dihidro-6h-pirido [4,3-d] pirimidina-5-onas
GT200500357A (es) Indazoles substituidos, composicones que los comprenden, procedimiento de su preparacion y utilizacion
NO20055612L (no) Anti-inflammatoriske fosfonatforbindelser
NO20063393L (no) Farmasoytiske preparater
AR039232A1 (es) Una formulacion farmaceutica que comprende al menos un compuesto seleccionado del grupo formado por hipnoticos no barbituricos y no benzodiacepinicos, y melatonina
SE0300457D0 (sv) Novel compounds