PA8566701A1 - Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion - Google Patents

Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Info

Publication number
PA8566701A1
PA8566701A1 PA20038566701A PA8566701A PA8566701A1 PA 8566701 A1 PA8566701 A1 PA 8566701A1 PA 20038566701 A PA20038566701 A PA 20038566701A PA 8566701 A PA8566701 A PA 8566701A PA 8566701 A1 PA8566701 A1 PA 8566701A1
Authority
PA
Panama
Prior art keywords
indazols
substituted
compositions
contain
manufacturing
Prior art date
Application number
PA20038566701A
Other languages
English (en)
Inventor
Dominique Damour
Corinne Terrier
Patrick Nemecek
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PA8566701A1 publication Critical patent/PA8566701A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

INDAZOLES SUBSTITUIDOS, COMPOSICIONES QUE LOS CONTIENEN, PROCEDIMIENTO PARA LA FABRICACION Y UTILIZACION. LA PRESENTE INVENCION SE REFIERE, EN PARTICULAR, A NUEVOS INDAZOLES SUBSTITUIDOS ESPECIFICOS, QUE PRESENTAN UNA ACTIVIDAD INHIBIDORA DE KINASAS, QUE TIENEN UNA ACTIVIDAD TERAPEUTICA, EN PARTICULAR EN ONCOLOGIA.
PA20038566701A 2002-03-11 2003-02-13 Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion PA8566701A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
PA8566701A1 true PA8566701A1 (es) 2003-12-10

Family

ID=27763684

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038566701A PA8566701A1 (es) 2002-03-11 2003-02-13 Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Country Status (29)

Country Link
US (2) US6858638B2 (es)
EP (1) EP1487803A1 (es)
JP (1) JP4643910B2 (es)
KR (1) KR20040091128A (es)
CN (1) CN100369899C (es)
AR (1) AR038914A1 (es)
AU (1) AU2003242808B2 (es)
BR (1) BR0308339A (es)
CA (1) CA2478540A1 (es)
EC (1) ECSP045286A (es)
FR (1) FR2836914B1 (es)
GT (1) GT200300031A (es)
HN (1) HN2003000094A (es)
HR (1) HRP20040825A2 (es)
IL (2) IL163805A0 (es)
MA (1) MA27176A1 (es)
MX (1) MXPA04008446A (es)
NO (1) NO20044261L (es)
OA (1) OA12784A (es)
PA (1) PA8566701A1 (es)
PE (1) PE20040071A1 (es)
PL (1) PL372389A1 (es)
RU (1) RU2004130280A (es)
SV (1) SV2003001493A (es)
TN (1) TNSN04175A1 (es)
TW (1) TW200303863A (es)
UY (1) UY27712A1 (es)
WO (1) WO2003078402A1 (es)
ZA (1) ZA200406730B (es)

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FR2864084B1 (fr) * 2003-12-17 2006-02-10 Aventis Pharma Sa Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments
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EP1778669A2 (en) * 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase inhibitors
RU2392272C2 (ru) * 2004-09-29 2010-06-20 Ф.Хоффманн-Ля Рош Аг Производные индазолона в качестве ингибиторов 11b-hsd1
WO2006044687A2 (en) 2004-10-15 2006-04-27 Takeda San Diego, Inc. Kinase inhibitors
SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
CA2620257A1 (en) * 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 map kinase inhibitors and methods for using the same
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP5131990B2 (ja) 2006-01-31 2013-01-30 アレイ バイオファーマ、インコーポレイテッド キナーゼ阻害剤およびその使用方法
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
CA2690619A1 (en) * 2007-07-16 2009-01-22 Abbott Laboratories Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
TWI537269B (zh) * 2009-05-26 2016-06-11 艾伯維巴哈馬有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘發劑
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
EP2632436B1 (en) 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
WO2012071374A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Methods of treatment using selective bcl-2 inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2016071293A2 (en) 2014-11-03 2016-05-12 Iomet Pharma Ltd Pharmaceutical compound
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
WO2019018853A1 (en) * 2017-07-21 2019-01-24 Kadmon Corporation, Llc INHIBITORS OF PROTEIN KINASE CONTAINING RHO-ASSOCIATED ROLL COIL
CN111479805A (zh) 2017-08-29 2020-07-31 罗格斯新泽西州立大学 治疗性吲唑
WO2023137041A1 (en) * 2022-01-12 2023-07-20 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途

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FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2836915B1 (fr) * 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
HN2003000094A (es) 2003-12-15
EP1487803A1 (fr) 2004-12-22
OA12784A (fr) 2006-07-10
US20040106667A1 (en) 2004-06-03
NO20044261L (no) 2004-11-25
ZA200406730B (en) 2005-08-24
TNSN04175A1 (fr) 2007-03-12
FR2836914B1 (fr) 2008-03-14
HRP20040825A2 (en) 2005-06-30
PE20040071A1 (es) 2004-02-13
US7473701B2 (en) 2009-01-06
US20050059722A1 (en) 2005-03-17
JP2005533004A (ja) 2005-11-04
ECSP045286A (es) 2004-10-26
KR20040091128A (ko) 2004-10-27
SV2003001493A (es) 2003-07-10
IL163805A (en) 2009-08-03
CN100369899C (zh) 2008-02-20
AU2003242808A1 (en) 2003-09-29
PL372389A1 (en) 2005-07-25
CA2478540A1 (fr) 2003-09-25
FR2836914A1 (fr) 2003-09-12
MA27176A1 (fr) 2005-01-03
MXPA04008446A (es) 2004-12-06
CN1642922A (zh) 2005-07-20
JP4643910B2 (ja) 2011-03-02
RU2004130280A (ru) 2005-06-27
AU2003242808B2 (en) 2008-09-18
GT200300031A (es) 2006-05-26
WO2003078402A1 (fr) 2003-09-25
TW200303863A (en) 2003-09-16
AR038914A1 (es) 2005-02-02
US6858638B2 (en) 2005-02-22
BR0308339A (pt) 2005-02-01
UY27712A1 (es) 2003-09-30
IL163805A0 (en) 2005-12-18

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