AR021542A1 - Un compuesto de sulfonamida y las composiciones y preparaciones farmaceuticas que lo contienen - Google Patents
Un compuesto de sulfonamida y las composiciones y preparaciones farmaceuticas que lo contienenInfo
- Publication number
- AR021542A1 AR021542A1 ARP990106177A ARP990106177A AR021542A1 AR 021542 A1 AR021542 A1 AR 021542A1 AR P990106177 A ARP990106177 A AR P990106177A AR P990106177 A ARP990106177 A AR P990106177A AR 021542 A1 AR021542 A1 AR 021542A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- aryl
- action
- lower alkyl
- heterocyclic group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se revelan compuestos de sulfonamida de la formula (1), en la cual: R1 es un grupo arilo o heterocíclico sustituido por lo menos por un sustituyenteseleccionado del grupo consistente en: (a) arilo, (b) un grupo heterocíclico sustituido por oxo o halogeno, (c) halogeno, (d) haloalquilo inferior, (e) alcoxiinferior opcionalmente sustituido por cicloalquilo inferior, (f) amino opcionalmente sustituido por lo menos por un sustituyente seleccionado del grupo queconsiste en alquilo inferior, opcionalmente sustituido por cicloalquilo inferior, carboxi protegido, acilo, alquil-carbamoilo inferior y alcan-sulfoniloinferior, (g) nitro, y (h) alquilo inferior opcionalmente sustituido por arilo; R2 es un alquilo inferior o alcoxi inferior; R3 es un hidrogeno o alquiloinferior; R4 es un alquenilo inferior opcionalmente sustituido por arilo o un grupo heterocíclico, arilo opcionalmente sustituido por carboxi o carboxiprotegido, alquilo inferior opcionalmente sustituido por aciloxi, amino opcionalmente sustituido por alquilo inferior, o grupo heterocíclico opcionalmentesustituido por halogeno; y A es un alquileno inferior o una sal del mismo. Estos compuestos son utiles para la profilaxis y el tratamiento de enfermedadescurables sobre la base deuna accion hipoglucémica y de aquellas enfermedades curables sobre la base de una accion inhibitoria de cGMP-PDE, una accionrelajante de los musculos lisos, una accion broncodilatadora, una accion vasodilatadora, una accion inhibitoria de las células de los musculos lisos y unaaccion inhibitoria de la alergia. También se revelan las composiciones y preparaciones farmacéuticas que contienen dichos compuestos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34617598 | 1998-12-04 | ||
| JP36754098 | 1998-12-24 | ||
| JP25928399 | 1999-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR021542A1 true AR021542A1 (es) | 2002-07-24 |
Family
ID=27334802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106177A AR021542A1 (es) | 1998-12-04 | 1999-12-03 | Un compuesto de sulfonamida y las composiciones y preparaciones farmaceuticas que lo contienen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6573274B1 (es) |
| EP (1) | EP1136492A4 (es) |
| KR (1) | KR20010086593A (es) |
| CN (1) | CN1335847A (es) |
| AR (1) | AR021542A1 (es) |
| AU (1) | AU769890B2 (es) |
| BR (1) | BR9916919A (es) |
| CA (1) | CA2352871A1 (es) |
| CZ (1) | CZ20011981A3 (es) |
| HK (1) | HK1044154A1 (es) |
| HU (1) | HUP0104549A3 (es) |
| IL (1) | IL143439A0 (es) |
| TR (1) | TR200101568T2 (es) |
| TW (1) | TW577889B (es) |
| WO (1) | WO2000034277A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1268942A (zh) * | 1997-06-27 | 2000-10-04 | 藤泽药品工业株式会社 | 磺酰胺化合物及其药物用途 |
| HUP0300725A3 (en) * | 2000-08-11 | 2005-11-28 | Pfizer | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| TW200533336A (en) * | 2004-03-02 | 2005-10-16 | Fujisawa Pharmaceutical Co | Concomitant drugs |
| US8133996B2 (en) * | 2007-02-06 | 2012-03-13 | Cipla Limited | Process for the preparation of ethyl-N-(2,3-dichloro-6-nitrobenzyl)glycine hydrochloride |
| JPWO2014123203A1 (ja) * | 2013-02-06 | 2017-02-02 | 京都薬品工業株式会社 | 糖尿病治療薬 |
| GB201321741D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| TWI663159B (zh) * | 2013-12-10 | 2019-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶（ｔｒｋ）抑制劑 |
| SI3762368T1 (sl) | 2018-03-08 | 2022-06-30 | Incyte Corporation | Aminopirazin diolne spojine kot zaviralci PI3K-y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215994A (en) | 1990-09-25 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic derivatives |
| EP0503838A3 (en) | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| US5128327A (en) | 1991-03-25 | 1992-07-07 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle |
| WO1993019067A1 (en) | 1991-09-12 | 1993-09-30 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine derivatives as angiotensin ii antagonists |
| DK0882718T3 (da) | 1995-12-28 | 2005-12-12 | Astellas Pharma Inc | Benzimidazolderivater |
| US6242474B1 (en) | 1997-06-27 | 2001-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| CN1268942A (zh) | 1997-06-27 | 2000-10-04 | 藤泽药品工业株式会社 | 磺酰胺化合物及其药物用途 |
-
1999
- 1999-12-01 KR KR1020017006948A patent/KR20010086593A/ko not_active Application Discontinuation
- 1999-12-01 TR TR2001/01568T patent/TR200101568T2/xx unknown
- 1999-12-01 EP EP99973290A patent/EP1136492A4/en not_active Withdrawn
- 1999-12-01 US US09/856,172 patent/US6573274B1/en not_active Expired - Fee Related
- 1999-12-01 AU AU14141/00A patent/AU769890B2/en not_active Ceased
- 1999-12-01 CZ CZ20011981A patent/CZ20011981A3/cs unknown
- 1999-12-01 WO PCT/JP1999/006748 patent/WO2000034277A1/ja not_active Application Discontinuation
- 1999-12-01 BR BR9916919-3A patent/BR9916919A/pt not_active IP Right Cessation
- 1999-12-01 IL IL14343999A patent/IL143439A0/xx unknown
- 1999-12-01 CN CN99816022A patent/CN1335847A/zh active Pending
- 1999-12-01 CA CA002352871A patent/CA2352871A1/en not_active Abandoned
- 1999-12-01 HU HU0104549A patent/HUP0104549A3/hu unknown
- 1999-12-02 TW TW088121089A patent/TW577889B/zh not_active IP Right Cessation
- 1999-12-03 AR ARP990106177A patent/AR021542A1/es not_active Application Discontinuation
-
2002
- 2002-08-06 HK HK02105752.5A patent/HK1044154A1/zh unknown
-
2003
- 2003-02-10 US US10/360,806 patent/US6890934B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR9916919A (pt) | 2002-01-15 |
| CA2352871A1 (en) | 2000-06-15 |
| HK1044154A1 (zh) | 2002-10-11 |
| CN1335847A (zh) | 2002-02-13 |
| US6890934B2 (en) | 2005-05-10 |
| EP1136492A1 (en) | 2001-09-26 |
| TR200101568T2 (tr) | 2001-10-22 |
| CZ20011981A3 (cs) | 2002-01-16 |
| AU1414100A (en) | 2000-06-26 |
| US6573274B1 (en) | 2003-06-03 |
| WO2000034277A1 (fr) | 2000-06-15 |
| HUP0104549A3 (en) | 2002-12-28 |
| IL143439A0 (en) | 2002-04-21 |
| AU769890B2 (en) | 2004-02-05 |
| KR20010086593A (ko) | 2001-09-13 |
| EP1136492A4 (en) | 2002-03-27 |
| HUP0104549A2 (hu) | 2002-04-29 |
| TW577889B (en) | 2004-03-01 |
| US20030171396A1 (en) | 2003-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |