AR076222A1 - Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen - Google Patents

Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen

Info

Publication number
AR076222A1
AR076222A1 ARP100101165A ARP100101165A AR076222A1 AR 076222 A1 AR076222 A1 AR 076222A1 AR P100101165 A ARP100101165 A AR P100101165A AR P100101165 A ARP100101165 A AR P100101165A AR 076222 A1 AR076222 A1 AR 076222A1
Authority
AR
Argentina
Prior art keywords
hydroxietil
azaisotheral
ona
quinolin
analogs
Prior art date
Application number
ARP100101165A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR076222A1 publication Critical patent/AR076222A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se relaciona con compuestos antibacterianos de formula (1) en la cual R1 representa alcoxilo; cada uno de U y V representa CH y W representa CH o N, o U representa N, V representa CH y W representa N, o cada uno de U y V representa N y W representa CH; R2 representa hidrogeno o fluor cuando W representa CH o R2 representa hidrogeno cuando W representa N; A representa O o CH2; Y representa CH o N; Q representa O o S; y n representa 0 o 1; y sales de tales compuestos.
ARP100101165A 2009-04-09 2010-04-07 Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen AR076222A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2009051510 2009-04-09

Publications (1)

Publication Number Publication Date
AR076222A1 true AR076222A1 (es) 2011-05-26

Family

ID=42199672

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101165A AR076222A1 (es) 2009-04-09 2010-04-07 Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen

Country Status (15)

Country Link
US (1) US8415375B2 (es)
EP (1) EP2417141B1 (es)
JP (1) JP5639639B2 (es)
KR (1) KR101729345B1 (es)
CN (1) CN102361875B (es)
AR (1) AR076222A1 (es)
AU (1) AU2010233387B2 (es)
BR (1) BRPI1015310A8 (es)
CA (1) CA2756727C (es)
ES (1) ES2438742T3 (es)
MX (1) MX2011010358A (es)
PL (1) PL2417141T3 (es)
RU (1) RU2540862C2 (es)
TW (1) TWI455937B (es)
WO (1) WO2010116337A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
WO2013003383A1 (en) * 2011-06-27 2013-01-03 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
WO2013038374A1 (en) 2011-09-16 2013-03-21 Actelion Pharmaceuticals Ltd Process for manufacturing a synthetic intermediate
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
EP0934932A4 (en) * 1996-08-22 2002-06-26 Meiji Seika Kaisha CHINOLINE DERIVATIVES AND PSYCHOTROPES MEDIUM
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
JP2008502689A (ja) 2004-06-15 2008-01-31 グラクソ　グループ　リミテッド 抗菌剤
CA2580621A1 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
CN101180298B (zh) * 2005-05-25 2011-04-27 埃科特莱茵药品有限公司 抗生素衍生物
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
JP5398984B2 (ja) * 2005-06-24 2014-01-29 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
CN101341126A (zh) * 2005-10-13 2009-01-07 莫弗凯姆联合化学股份公司 具有抗菌活性的5-喹啉衍生物
WO2007138974A1 (ja) * 2006-05-26 2007-12-06 Toyama Chemical Co., Ltd. 新規な複素環化合物またはその塩ならびにその中間体
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
WO2008071964A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Naphthyridine bactericides
TW200831517A (en) 2006-12-15 2008-08-01 Astrazeneca Ab Chemical compounds
WO2008071981A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Piperidines for the treatment of bacterial infections
WO2008071962A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
BRPI0810064B8 (pt) 2007-04-20 2021-05-25 Glaxo Group Ltd compostos contendo nitrogênio tricíclico como agentes antibacterianos, composições farmacêuticas que compreendem os ditos compostos e uso dos mesmos para o tratamento de infecções bacterianas em mamíferos
EP2005995A1 (en) 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
WO2009001126A1 (en) 2007-06-27 2008-12-31 Astrazeneca Ab Substituted piperidine derivatives and their use as antibaterial agents
GB0800367D0 (en) 2008-01-09 2008-02-20 Glaxo Group Ltd Compounds
CA2713187C (en) 2008-02-22 2016-06-07 Actelion Pharmaceuticals Ltd Oxazolidinone derivatives
WO2009147616A1 (en) * 2008-06-03 2009-12-10 Actelion Pharmaceuticals Ltd [4-(1-amino-ethyl) -cyclohexyl] -methyl-amine and [6-(1-amino-ethyl) -tetrahydro- pyran-3-yl] -methyl-amine derivatives as antibacterials
ES2628091T3 (es) 2008-10-10 2017-08-01 Idorsia Pharmaceuticals Ltd Antibióticos de oxazolidinilo
CN102232078B (zh) 2008-12-12 2014-07-16 埃科特莱茵药品有限公司 5-氨基-2-(1-羟基-乙基)-四氢吡喃衍生物
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
CA2756727A1 (en) 2010-10-14
KR101729345B1 (ko) 2017-04-21
RU2540862C2 (ru) 2015-02-10
JP5639639B2 (ja) 2014-12-10
BRPI1015310A2 (pt) 2016-05-24
WO2010116337A1 (en) 2010-10-14
CA2756727C (en) 2017-05-02
PL2417141T3 (pl) 2014-03-31
TWI455937B (zh) 2014-10-11
CN102361875A (zh) 2012-02-22
AU2010233387B2 (en) 2015-01-15
ES2438742T3 (es) 2014-01-20
EP2417141B1 (en) 2013-10-16
TW201040182A (en) 2010-11-16
MX2011010358A (es) 2011-11-01
JP2012523407A (ja) 2012-10-04
KR20120014240A (ko) 2012-02-16
AU2010233387A1 (en) 2011-11-24
CN102361875B (zh) 2014-08-20
US20120040989A1 (en) 2012-02-16
EP2417141A1 (en) 2012-02-15
BRPI1015310A8 (pt) 2017-12-26
US8415375B2 (en) 2013-04-09
RU2011145052A (ru) 2013-05-20

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