AR074453A1 - Compuestos 4-(azacicloalquil ) benceno-1,3-diol, como inhibidores de la tirosinasa y su uso en medicina humana y tambien en cosmetica - Google Patents
Compuestos 4-(azacicloalquil ) benceno-1,3-diol, como inhibidores de la tirosinasa y su uso en medicina humana y tambien en cosmeticaInfo
- Publication number
- AR074453A1 AR074453A1 ARP090104648A ARP090104648A AR074453A1 AR 074453 A1 AR074453 A1 AR 074453A1 AR P090104648 A ARP090104648 A AR P090104648A AR P090104648 A ARP090104648 A AR P090104648A AR 074453 A1 AR074453 A1 AR 074453A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- alkyl
- compounds
- radical
- aryl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones que los contiene y al uso de dichos compuestos en composiciones farmacéuticas o cosméticas, para utilizar en el tratamiento o en la prevención de trastornos pigmentarios. Reivindicación 1: Compuestos de la siguiente fórmula general (1) en la cual R1 representa un radical alquilo C1-5, cicloalquilo C3-6, arilo, arilo sustituido, aralquilo, alcoxi C1-5, amino que corresponde a la estructura a) -NR2R3 en la cual R2 representa: hidrógeno, alquilo C1-5, cicloalquilo C3-6, arilo, arilo sustituido, piridilo, aralquilo, un radical que corresponde a la estructura (b) en la cual p puede tener un valor de 1 o 2, un radical que corresponde a la estructura (c) CHR4R5 en la cual R4 representa: un radical carboximetil-COOCH3 o un radical carboxietil-COOEt, alquilo C1-3, hidrógeno, y R5 representa: un radical arilo sustituido o insustituido, cicloalquil C3-6, piridilo y R3 representa: un hidrógeno, alquilo C1-5 o R1 también puede representar un radical que corresponde a la fórmula d) CR6R7R8 en la cual R6 representa: un hidrógeno, alquilo C1-5, cicloalquilo C3-6, arilo, arilo sustituido, piridilo, aralquilo, R7 representa: hidrógeno, alquilo C1-5, y R8 representa: un hidrógeno, hidroxilo, amino, alcoxi C1-3; Y representa un hidrógeno o un flúor y m y n puede tener el valor de 0, 1 o 2, y también las sales de los compuestos de la fórmula (1), y las formas isoméricas y enantioméricas de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19346008P | 2008-12-02 | 2008-12-02 | |
FR0858207A FR2939135B1 (fr) | 2008-12-02 | 2008-12-02 | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074453A1 true AR074453A1 (es) | 2011-01-19 |
Family
ID=40852143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090104648A AR074453A1 (es) | 2008-12-02 | 2009-12-02 | Compuestos 4-(azacicloalquil ) benceno-1,3-diol, como inhibidores de la tirosinasa y su uso en medicina humana y tambien en cosmetica |
Country Status (14)
Country | Link |
---|---|
US (5) | US8299259B2 (es) |
EP (2) | EP2907804A1 (es) |
JP (1) | JP5346092B2 (es) |
KR (1) | KR101308808B1 (es) |
CN (2) | CN102224139B (es) |
AR (1) | AR074453A1 (es) |
AU (1) | AU2009324081B2 (es) |
BR (1) | BRPI0916480B1 (es) |
CA (1) | CA2742709C (es) |
ES (1) | ES2536072T3 (es) |
FR (1) | FR2939135B1 (es) |
MX (1) | MX2011005478A (es) |
RU (1) | RU2499794C2 (es) |
WO (1) | WO2010063774A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2939135B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
FR2953834B1 (fr) * | 2009-12-10 | 2012-01-13 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
FR3000065A1 (fr) * | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes |
WO2014125233A2 (fr) | 2013-02-14 | 2014-08-21 | Galderma Research & Development | Procédé de synthèse de 4-piperidin-4-yl-benzène-1,3-diol et de ses sels et nouveau composé 4-(2,4-dihydroxy-phényl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle |
CN105939704A (zh) | 2013-12-04 | 2016-09-14 | 盖尔德马研究及发展公司 | 优选包含类维生素a的脂质微胶囊以及含有其的组合物、制造其的方法及其在皮肤病学中的用途 |
JP6492531B2 (ja) * | 2014-10-27 | 2019-04-03 | セイコーエプソン株式会社 | 表示装置、及び、表示装置の制御方法 |
WO2016193588A1 (fr) * | 2015-05-29 | 2016-12-08 | Galderma Research & Development | Compositions comprenant au moins un principe actif disperse et des microcapsules lipidiques |
US10550097B2 (en) | 2015-07-23 | 2020-02-04 | Dsm Ip Assets B.V. | Selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
EP3668853B1 (en) * | 2017-08-16 | 2021-09-29 | GlaxoSmithKline Intellectual Property Development Limited | Novel compounds |
JP7346425B2 (ja) * | 2018-01-11 | 2023-09-19 | セントラス セラピューティクス | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
CN109020996B (zh) * | 2018-09-03 | 2020-09-11 | 常州工程职业技术学院 | 一种具有光活性的杂多环化合物及其制备方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0651619B2 (ja) | 1988-05-09 | 1994-07-06 | 株式会社クラレ | 美白剤 |
FR2704428B1 (fr) | 1993-04-29 | 1995-06-09 | Oreal | Utilisation de dérivés de la résorcine substitués en position(s) 4, 4 et 5 ou 4 et 6 dans des compositions cosmétiques ou dermopharmaceutiques à action dépigmentante. |
BR9803596A (pt) * | 1997-09-23 | 2000-04-25 | Pfizer Prod Inc | Derivados do resorcinol. |
KR100488845B1 (ko) * | 1999-03-22 | 2005-05-11 | 화이자 인코포레이티드 | 레조르시놀 유도체 |
HN2000000033A (es) * | 1999-03-22 | 2001-02-02 | Pfizer Prod Inc | Composicion de resorcinol |
BR0113798A (pt) * | 2000-09-11 | 2003-07-08 | Pfizer Prod Inc | Derivados de resorcinol |
CA2423262A1 (en) * | 2000-09-21 | 2002-03-28 | Pfizer Products Inc. | Resorcinol derivatives |
US6852310B2 (en) | 2002-08-23 | 2005-02-08 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
US6875425B2 (en) | 2002-12-12 | 2005-04-05 | Unilever Home & Personal Care Usa | Skin lightening agents, compositions and methods |
CA2515717A1 (en) * | 2003-02-10 | 2004-08-19 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
EP1599447A1 (en) * | 2003-02-28 | 2005-11-30 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
US7300646B2 (en) | 2004-02-27 | 2007-11-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
US20060210498A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives for skin |
US20060210497A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives |
DE102005061657A1 (de) * | 2005-06-16 | 2006-12-28 | Merck Patent Gmbh | Verwendung von substituierten Piperazin- und Morpholinderivaten |
FR2937972B1 (fr) * | 2008-11-04 | 2013-03-29 | Galderma Res & Dev | Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
FR2937973B1 (fr) * | 2008-11-04 | 2010-11-05 | Galderma Res & Dev | Modulateurs des recepteurs de la melanocortine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
FR2939136B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
FR2939135B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
-
2008
- 2008-12-02 FR FR0858207A patent/FR2939135B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-02 US US13/131,363 patent/US8299259B2/en active Active
- 2009-12-02 KR KR1020117015286A patent/KR101308808B1/ko active IP Right Grant
- 2009-12-02 EP EP15154368.3A patent/EP2907804A1/en not_active Withdrawn
- 2009-12-02 EP EP09763959.5A patent/EP2373620B1/en active Active
- 2009-12-02 WO PCT/EP2009/066268 patent/WO2010063774A1/en active Application Filing
- 2009-12-02 MX MX2011005478A patent/MX2011005478A/es active IP Right Grant
- 2009-12-02 CA CA2742709A patent/CA2742709C/en active Active
- 2009-12-02 CN CN200980147097.6A patent/CN102224139B/zh not_active Expired - Fee Related
- 2009-12-02 RU RU2011127126/04A patent/RU2499794C2/ru active
- 2009-12-02 JP JP2011539019A patent/JP5346092B2/ja not_active Expired - Fee Related
- 2009-12-02 AR ARP090104648A patent/AR074453A1/es active IP Right Grant
- 2009-12-02 BR BRPI0916480A patent/BRPI0916480B1/pt not_active IP Right Cessation
- 2009-12-02 AU AU2009324081A patent/AU2009324081B2/en not_active Ceased
- 2009-12-02 CN CN201410539219.9A patent/CN104666299A/zh active Pending
- 2009-12-02 ES ES09763959.5T patent/ES2536072T3/es active Active
-
2012
- 2012-09-12 US US13/611,546 patent/US8697726B2/en active Active
-
2014
- 2014-03-07 US US14/200,954 patent/US20140187532A1/en not_active Abandoned
- 2014-08-29 US US14/469,199 patent/US8993596B2/en active Active
-
2015
- 2015-03-17 US US14/659,800 patent/US20150191451A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2373620A1 (en) | 2011-10-12 |
JP2012510504A (ja) | 2012-05-10 |
CN104666299A (zh) | 2015-06-03 |
US20130023516A1 (en) | 2013-01-24 |
RU2011127126A (ru) | 2013-01-10 |
EP2907804A1 (en) | 2015-08-19 |
AU2009324081B2 (en) | 2012-10-11 |
AU2009324081A1 (en) | 2010-06-10 |
ES2536072T3 (es) | 2015-05-20 |
KR20110091803A (ko) | 2011-08-12 |
FR2939135A1 (fr) | 2010-06-04 |
MX2011005478A (es) | 2011-06-20 |
CN102224139B (zh) | 2014-11-19 |
CA2742709A1 (en) | 2010-06-10 |
FR2939135B1 (fr) | 2010-12-03 |
BRPI0916480B1 (pt) | 2019-01-15 |
JP5346092B2 (ja) | 2013-11-20 |
WO2010063774A1 (en) | 2010-06-10 |
CN102224139A (zh) | 2011-10-19 |
US8993596B2 (en) | 2015-03-31 |
KR101308808B1 (ko) | 2013-09-13 |
US8299259B2 (en) | 2012-10-30 |
CA2742709C (en) | 2013-10-08 |
US20140371197A1 (en) | 2014-12-18 |
RU2499794C2 (ru) | 2013-11-27 |
US8697726B2 (en) | 2014-04-15 |
EP2373620B1 (en) | 2015-03-18 |
US20150191451A1 (en) | 2015-07-09 |
BRPI0916480A2 (pt) | 2016-06-14 |
US20140187532A1 (en) | 2014-07-03 |
US20110311466A1 (en) | 2011-12-22 |
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