BRPI1015310A8 - Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacteriana - Google Patents
Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacterianaInfo
- Publication number
- BRPI1015310A8 BRPI1015310A8 BRPI1015310A BRPI1015310A BRPI1015310A8 BR PI1015310 A8 BRPI1015310 A8 BR PI1015310A8 BR PI1015310 A BRPI1015310 A BR PI1015310A BR PI1015310 A BRPI1015310 A BR PI1015310A BR PI1015310 A8 BRPI1015310 A8 BR PI1015310A8
- Authority
- BR
- Brazil
- Prior art keywords
- azaisosteric
- quinolin
- analogs
- hydroxy
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
DERIVADOS DE 2-HIDRÓXI-ETIL-1H-QUINOLIN-2-ONA E SEUS ANÁLOGOS AZAISOESTÉRICOS COM ATIVIDADE ANTIBACTERIANA A invenção se refere aos compostos antibacterianos da fórmula I, em que R1 represente alcóxi; cada um dentre U e V representa CH, e W representa CH ou N, ou U representa N, V representa CH, e W representa N, ou cada um dentre U e V representa N, e W representa CH; R2 representa hidrogênio ou flúor quando W representa CH, ou R2 representa hidrogênio quando W representa N; A representa O ou CH2; Y representa CH ou N; Q representa O ou S; e n representa O ou 1; e sais de tais compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2009051510 | 2009-04-09 | ||
PCT/IB2010/051517 WO2010116337A1 (en) | 2009-04-09 | 2010-04-08 | 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI1015310A2 BRPI1015310A2 (pt) | 2016-05-24 |
BRPI1015310A8 true BRPI1015310A8 (pt) | 2017-12-26 |
Family
ID=42199672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1015310A BRPI1015310A8 (pt) | 2009-04-09 | 2010-04-08 | Derivados de 2-hidróxi-etil-1h-quinolin-2-ona e seus análogos azaisoestéricos com atividade antibacteriana |
Country Status (15)
Country | Link |
---|---|
US (1) | US8415375B2 (pt) |
EP (1) | EP2417141B1 (pt) |
JP (1) | JP5639639B2 (pt) |
KR (1) | KR101729345B1 (pt) |
CN (1) | CN102361875B (pt) |
AR (1) | AR076222A1 (pt) |
AU (1) | AU2010233387B2 (pt) |
BR (1) | BRPI1015310A8 (pt) |
CA (1) | CA2756727C (pt) |
ES (1) | ES2438742T3 (pt) |
MX (1) | MX2011010358A (pt) |
PL (1) | PL2417141T3 (pt) |
RU (1) | RU2540862C2 (pt) |
TW (1) | TWI455937B (pt) |
WO (1) | WO2010116337A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR076222A1 (es) | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen |
CA2840060A1 (en) * | 2011-06-27 | 2013-01-03 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
TW201313726A (zh) | 2011-09-16 | 2013-04-01 | Actelion Pharmaceuticals Ltd | 製造合成之中間體之方法 |
TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1095611A1 (ru) * | 1982-09-10 | 2007-06-27 | Краснодарский ордена Трудового Красного Знамени политехнический институт | Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью |
EG20543A (en) * | 1992-10-30 | 1999-07-31 | Procter & Gamble | Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones |
EP0934932A4 (en) * | 1996-08-22 | 2002-06-26 | Meiji Seika Kaisha | CHINOLINE DERIVATIVES AND PSYCHOTROPES MEDIUM |
GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
AR040335A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
JP2008502689A (ja) | 2004-06-15 | 2008-01-31 | グラクソ グループ リミテッド | 抗菌剤 |
WO2006032466A2 (en) | 2004-09-24 | 2006-03-30 | Actelion Pharmaceuticals Ltd | New bicyclic antibiotics |
WO2006126171A2 (en) * | 2005-05-25 | 2006-11-30 | Actelion Pharmaceuticals Ltd | New antibiotic derivatives |
MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
WO2006137485A1 (ja) * | 2005-06-24 | 2006-12-28 | Toyama Chemical Co., Ltd. | 新規な含窒素複素環化合物およびその塩 |
CN101341126A (zh) * | 2005-10-13 | 2009-01-07 | 莫弗凯姆联合化学股份公司 | 具有抗菌活性的5-喹啉衍生物 |
KR101409261B1 (ko) * | 2006-05-26 | 2014-06-18 | 다이쇼 세이야꾸 가부시끼가이샤 | 신규의 복소환 화합물 또는 그 염 및 그 중간체 |
EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
WO2008071981A1 (en) | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Piperidines for the treatment of bacterial infections |
WO2008071964A1 (en) | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Naphthyridine bactericides |
WO2008071962A1 (en) | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Pteridines and pyrimidinopyridines as antibacterial agents |
TW200831517A (en) | 2006-12-15 | 2008-08-01 | Astrazeneca Ab | Chemical compounds |
EP2137196B1 (en) | 2007-04-20 | 2010-10-06 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
EP2005995A1 (en) | 2007-06-22 | 2008-12-24 | Glaxo Group Limited | Heterocyclic compounds for the treatment of tuberculosis |
WO2009001126A1 (en) | 2007-06-27 | 2008-12-31 | Astrazeneca Ab | Substituted piperidine derivatives and their use as antibaterial agents |
GB0800367D0 (en) | 2008-01-09 | 2008-02-20 | Glaxo Group Ltd | Compounds |
TWI429643B (zh) | 2008-02-22 | 2014-03-11 | Actelion Pharmaceuticals Ltd | 唑啶酮衍生物 |
PL2297107T3 (pl) | 2008-06-03 | 2014-04-30 | Idorsia Pharmaceuticals Ltd | Pochodne [4-(1-aminoetylo)cykloheksylo]metyloaminy i [6-(1-aminoetylo)tetrahydropiran-3-ylo]-metyloaminy jako środki przeciwbakteryjne |
CN102164919B (zh) | 2008-10-10 | 2014-04-09 | 埃科特莱茵药品有限公司 | 噁唑烷基抗生素 |
MX2011005905A (es) | 2008-12-12 | 2011-06-20 | Actelion Pharmaceuticals Ltd | Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano. |
AR076222A1 (es) | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen |
-
2010
- 2010-04-07 AR ARP100101165A patent/AR076222A1/es unknown
- 2010-04-08 BR BRPI1015310A patent/BRPI1015310A8/pt not_active Application Discontinuation
- 2010-04-08 WO PCT/IB2010/051517 patent/WO2010116337A1/en active Application Filing
- 2010-04-08 TW TW099110909A patent/TWI455937B/zh not_active IP Right Cessation
- 2010-04-08 JP JP2012504122A patent/JP5639639B2/ja not_active Expired - Fee Related
- 2010-04-08 EP EP10714481.8A patent/EP2417141B1/en not_active Not-in-force
- 2010-04-08 US US13/263,922 patent/US8415375B2/en not_active Expired - Fee Related
- 2010-04-08 RU RU2011145052/04A patent/RU2540862C2/ru not_active IP Right Cessation
- 2010-04-08 AU AU2010233387A patent/AU2010233387B2/en not_active Ceased
- 2010-04-08 CN CN201080013196.8A patent/CN102361875B/zh not_active Expired - Fee Related
- 2010-04-08 KR KR1020117023354A patent/KR101729345B1/ko active IP Right Grant
- 2010-04-08 MX MX2011010358A patent/MX2011010358A/es active IP Right Grant
- 2010-04-08 PL PL10714481T patent/PL2417141T3/pl unknown
- 2010-04-08 CA CA2756727A patent/CA2756727C/en not_active Expired - Fee Related
- 2010-04-08 ES ES10714481.8T patent/ES2438742T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
RU2011145052A (ru) | 2013-05-20 |
CN102361875B (zh) | 2014-08-20 |
ES2438742T3 (es) | 2014-01-20 |
CA2756727A1 (en) | 2010-10-14 |
TWI455937B (zh) | 2014-10-11 |
PL2417141T3 (pl) | 2014-03-31 |
MX2011010358A (es) | 2011-11-01 |
JP2012523407A (ja) | 2012-10-04 |
AU2010233387B2 (en) | 2015-01-15 |
EP2417141B1 (en) | 2013-10-16 |
RU2540862C2 (ru) | 2015-02-10 |
CN102361875A (zh) | 2012-02-22 |
EP2417141A1 (en) | 2012-02-15 |
JP5639639B2 (ja) | 2014-12-10 |
KR20120014240A (ko) | 2012-02-16 |
AU2010233387A1 (en) | 2011-11-24 |
TW201040182A (en) | 2010-11-16 |
AR076222A1 (es) | 2011-05-26 |
BRPI1015310A2 (pt) | 2016-05-24 |
CA2756727C (en) | 2017-05-02 |
US8415375B2 (en) | 2013-04-09 |
KR101729345B1 (ko) | 2017-04-21 |
US20120040989A1 (en) | 2012-02-16 |
WO2010116337A1 (en) | 2010-10-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
B25C | Requirement related to requested transfer of rights |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |