BR112014017735A8 - Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto - Google Patents

Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto

Info

Publication number
BR112014017735A8
BR112014017735A8 BR112014017735A BR112014017735A BR112014017735A8 BR 112014017735 A8 BR112014017735 A8 BR 112014017735A8 BR 112014017735 A BR112014017735 A BR 112014017735A BR 112014017735 A BR112014017735 A BR 112014017735A BR 112014017735 A8 BR112014017735 A8 BR 112014017735A8
Authority
BR
Brazil
Prior art keywords
receptor antagonists
compound
pharmaceutical composition
heterocyclic amide
amide derivative
Prior art date
Application number
BR112014017735A
Other languages
English (en)
Other versions
BR112014017735B1 (pt
BR112014017735A2 (pt
Inventor
Hilpert Kurt
Hubler Francis
Kimmerlin Thierry
Renneberg Dorte
Stamm Simon
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BR112014017735A2 publication Critical patent/BR112014017735A2/pt
Publication of BR112014017735A8 publication Critical patent/BR112014017735A8/pt
Publication of BR112014017735B1 publication Critical patent/BR112014017735B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE AMIDA HETEROCÍCLICOS COMO ANTAGONISTAS DO RECEPTOR DE P2X7. A invenção refere-se aos derivados de amida heterocíclicos da fórmula (I), em que R1, R2, R3, X e n são tais como definidos na descrição, sai preparação e sua utilização como com postos farmaceuticamente ativos.
BR112014017735-0A 2012-01-20 2013-01-18 Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto BR112014017735B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2012/050282 2012-01-20
IB2012050282 2012-01-20
PCT/IB2013/050479 WO2013108227A1 (en) 2012-01-20 2013-01-18 Heterocyclic amide derivatives as p2x7 receptor antagonists

Publications (3)

Publication Number Publication Date
BR112014017735A2 BR112014017735A2 (pt) 2017-06-27
BR112014017735A8 true BR112014017735A8 (pt) 2017-12-26
BR112014017735B1 BR112014017735B1 (pt) 2022-06-28

Family

ID=47757670

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014017735-0A BR112014017735B1 (pt) 2012-01-20 2013-01-18 Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto

Country Status (23)

Country Link
US (1) US9409917B2 (pt)
EP (1) EP2804865B1 (pt)
JP (1) JP6111268B2 (pt)
KR (1) KR102033190B1 (pt)
CN (1) CN104066737B (pt)
AR (1) AR089753A1 (pt)
AU (1) AU2013210682B2 (pt)
BR (1) BR112014017735B1 (pt)
CA (1) CA2863228C (pt)
CL (1) CL2014001772A1 (pt)
EA (1) EA024204B1 (pt)
ES (1) ES2563189T3 (pt)
HK (1) HK1203932A1 (pt)
IL (1) IL233662A0 (pt)
MA (1) MA35893B1 (pt)
MX (1) MX336247B (pt)
NZ (1) NZ628910A (pt)
PH (1) PH12014501415A1 (pt)
PL (1) PL2804865T3 (pt)
SG (1) SG11201403933UA (pt)
TW (1) TWI576347B (pt)
WO (1) WO2013108227A1 (pt)
ZA (1) ZA201406085B (pt)

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Also Published As

Publication number Publication date
EA201400822A1 (ru) 2014-12-30
CN104066737A (zh) 2014-09-24
MA35893B1 (fr) 2014-12-01
EA024204B1 (ru) 2016-08-31
BR112014017735B1 (pt) 2022-06-28
IL233662A0 (en) 2014-08-31
PL2804865T3 (pl) 2016-06-30
JP2015504086A (ja) 2015-02-05
MX336247B (es) 2016-01-13
US9409917B2 (en) 2016-08-09
TWI576347B (zh) 2017-04-01
BR112014017735A2 (pt) 2017-06-27
CA2863228C (en) 2020-07-21
AU2013210682B2 (en) 2017-05-25
SG11201403933UA (en) 2014-08-28
KR20140112567A (ko) 2014-09-23
NZ628910A (en) 2016-02-26
TW201333013A (zh) 2013-08-16
CN104066737B (zh) 2016-06-08
JP6111268B2 (ja) 2017-04-05
EP2804865A1 (en) 2014-11-26
WO2013108227A1 (en) 2013-07-25
PH12014501415A1 (en) 2014-09-22
CL2014001772A1 (es) 2014-10-17
AU2013210682A1 (en) 2014-09-11
KR102033190B1 (ko) 2019-10-16
AR089753A1 (es) 2014-09-17
EP2804865B1 (en) 2015-12-23
HK1203932A1 (en) 2015-11-06
ES2563189T3 (es) 2016-03-11
CA2863228A1 (en) 2013-07-25
MX2014008736A (es) 2014-08-29
US20150025075A1 (en) 2015-01-22
ZA201406085B (en) 2016-05-25

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