AU2003288640A1 - Benzamide inhibitors of the p2x7 receptor - Google Patents

Benzamide inhibitors of the p2x7 receptor

Info

Publication number
AU2003288640A1
AU2003288640A1 AU2003288640A AU2003288640A AU2003288640A1 AU 2003288640 A1 AU2003288640 A1 AU 2003288640A1 AU 2003288640 A AU2003288640 A AU 2003288640A AU 2003288640 A AU2003288640 A AU 2003288640A AU 2003288640 A1 AU2003288640 A1 AU 2003288640A1
Authority
AU
Australia
Prior art keywords
receptor
benzamide inhibitors
benzamide
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003288640A
Inventor
Mark A. Dombroski
Allen J. Duplantier
Chakrapani Subramanyam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of AU2003288640A1 publication Critical patent/AU2003288640A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
AU2003288640A 2002-12-31 2003-12-30 Benzamide inhibitors of the p2x7 receptor Abandoned AU2003288640A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43722802P 2002-12-31 2002-12-31
US60/437,228 2002-12-31
PCT/IB2003/006232 WO2004058731A1 (en) 2002-12-31 2003-12-30 Benzamide inhibitors of the p2x7 receptor

Publications (1)

Publication Number Publication Date
AU2003288640A1 true AU2003288640A1 (en) 2004-07-22

Family

ID=32682421

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003288640A Abandoned AU2003288640A1 (en) 2002-12-31 2003-12-30 Benzamide inhibitors of the p2x7 receptor

Country Status (7)

Country Link
EP (1) EP1581507A1 (en)
JP (1) JP2006513205A (en)
AU (1) AU2003288640A1 (en)
BR (1) BR0317844A (en)
CA (1) CA2511189A1 (en)
MX (1) MXPA05007130A (en)
WO (1) WO2004058731A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
BRPI0410349A (en) * 2003-05-12 2006-05-30 Pfizer Prod Inc p2x7 receptor benzamide inhibitors
EP1837330B1 (en) * 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
WO2006003500A1 (en) 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursers
EP1789551A2 (en) * 2004-08-31 2007-05-30 Sylentis S.A.U. Methods and compositions to inhibit p2x7 receptor expression
WO2007056046A1 (en) * 2005-11-07 2007-05-18 Abbott Laboratories P2x7 receptor antagonists and methods of use
PL2105164T3 (en) 2008-03-25 2011-05-31 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
PL2243772T3 (en) 2009-04-14 2012-05-31 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
US20130195919A1 (en) 2010-03-05 2013-08-01 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
WO2011141194A1 (en) 2010-05-14 2011-11-17 Affectis Pharmaceuticals Ag Novel methods for the preparation of p2x7r antagonists
TWI518075B (en) * 2010-10-01 2016-01-21 大正製藥股份有限公司 1,2,4-triazolone derivatives
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
CN103391923A (en) 2011-02-22 2013-11-13 埃科特莱茵药品有限公司 Benzamide derivatives as p2x7 receptor antagonists
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
AR087274A1 (en) 2011-07-22 2014-03-12 Actelion Pharmaceuticals Ltd DERIVATIVES OF AMETAS HETEROCICLICAS AS ANTAGONISTAS OF RECEPTORS P2X7
WO2013108227A1 (en) 2012-01-20 2013-07-25 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
TWI568722B (en) * 2012-06-15 2017-02-01 葛蘭馬克製藥公司 Triazolone compounds as mpges-1 inhibitors
AU2013356850B2 (en) 2012-12-12 2018-02-01 Idorsia Pharmaceuticals Ltd Indole carboxamide derivatives as P2X7 receptor antagonists
CN104854087B (en) 2012-12-18 2017-03-22 埃科特莱茵药品有限公司 Indole carboxamide derivatives as P2X7 receptor antagonists
CN104918946B (en) 2013-01-22 2017-03-29 埃科特莱茵药品有限公司 As P2X7The heterocyclic amide derivative of receptor antagonist
CN104918617B (en) 2013-01-22 2017-05-10 埃科特莱茵药品有限公司 Heterocyclic amide derivatives as p2x7 receptor antagonists
US9988373B2 (en) 2013-12-26 2018-06-05 Shionogi & Co., Ltd. Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same
BR112017022654A2 (en) 2015-04-24 2018-07-10 Shionogi & Co., Ltd. 6-membered heterocyclic derivative and pharmaceutical composition comprising the same
KR102528627B1 (en) 2016-10-17 2023-05-03 시오노기 앤드 컴파니, 리미티드 Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical compositions containing them
WO2020036133A1 (en) * 2018-08-17 2020-02-20 クミアイ化学工業株式会社 3-(1h-1,2,4-triazole-1-yl) benzoic acid amide derivative and harmful organism control agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4405614A1 (en) * 1994-02-22 1995-08-24 Bayer Ag Substituted triazolinones
IL130286A0 (en) * 1996-12-23 2000-06-01 Du Pont Pharm Co Nitrogen containing heteroaromatics as factor Xa inhibitors
PA8557501A1 (en) * 2001-11-12 2003-06-30 Pfizer Prod Inc BENZAMIDA, HETEROARILAMIDA AND INVESTED AMIDAS

Also Published As

Publication number Publication date
WO2004058731A1 (en) 2004-07-15
MXPA05007130A (en) 2005-08-26
EP1581507A1 (en) 2005-10-05
BR0317844A (en) 2005-12-06
CA2511189A1 (en) 2004-07-15
JP2006513205A (en) 2006-04-20

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