MA35893B1 - Dérivés d'amide hétérocyclique comme antagonistes du récepteur p2x7 - Google Patents

Dérivés d'amide hétérocyclique comme antagonistes du récepteur p2x7

Info

Publication number
MA35893B1
MA35893B1 MA37252A MA37252A MA35893B1 MA 35893 B1 MA35893 B1 MA 35893B1 MA 37252 A MA37252 A MA 37252A MA 37252 A MA37252 A MA 37252A MA 35893 B1 MA35893 B1 MA 35893B1
Authority
MA
Morocco
Prior art keywords
amide derivatives
receptor antagonists
heterocyclic amide
heterocyclic
derivatives
Prior art date
Application number
MA37252A
Other languages
English (en)
Inventor
Kurt Hilpert
Francis Hubler
Thierry Kimmerlin
Dorte Renneberg
Simon Stamm
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA35893B1 publication Critical patent/MA35893B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des dérivés d'amide hétérocyclique de formule (i), dans laquelle r1, r2, r3, x et n sont tels que définis dans la description, leur préparation et leur utilisation comme composés pharmaceutiquement actifs.
MA37252A 2012-01-20 2014-07-31 Dérivés d'amide hétérocyclique comme antagonistes du récepteur p2x7 MA35893B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2012050282 2012-01-20
PCT/IB2013/050479 WO2013108227A1 (fr) 2012-01-20 2013-01-18 Dérivés d'amide hétérocyclique comme antagonistes du récepteur p2x7

Publications (1)

Publication Number Publication Date
MA35893B1 true MA35893B1 (fr) 2014-12-01

Family

ID=47757670

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37252A MA35893B1 (fr) 2012-01-20 2014-07-31 Dérivés d'amide hétérocyclique comme antagonistes du récepteur p2x7

Country Status (23)

Country Link
US (1) US9409917B2 (fr)
EP (1) EP2804865B1 (fr)
JP (1) JP6111268B2 (fr)
KR (1) KR102033190B1 (fr)
CN (1) CN104066737B (fr)
AR (1) AR089753A1 (fr)
AU (1) AU2013210682B2 (fr)
BR (1) BR112014017735B1 (fr)
CA (1) CA2863228C (fr)
CL (1) CL2014001772A1 (fr)
EA (1) EA024204B1 (fr)
ES (1) ES2563189T3 (fr)
HK (1) HK1203932A1 (fr)
IL (1) IL233662A0 (fr)
MA (1) MA35893B1 (fr)
MX (1) MX336247B (fr)
NZ (1) NZ628910A (fr)
PH (1) PH12014501415A1 (fr)
PL (1) PL2804865T3 (fr)
SG (1) SG11201403933UA (fr)
TW (1) TWI576347B (fr)
WO (1) WO2013108227A1 (fr)
ZA (1) ZA201406085B (fr)

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US9718774B2 (en) 2012-12-12 2017-08-01 Idorsia Pharmaceuticals Ltd Indole carboxamide derivatives as P2X7 receptor antagonist
AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
EP2956135B1 (fr) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7
KR102220847B1 (ko) 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
EP3122347B1 (fr) * 2014-03-26 2020-06-03 The Children's Medical Center Corporation Celastrol derivées destinées au traitement de l'obésité
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JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP2024508526A (ja) 2021-03-04 2024-02-27 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤

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AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
KR102220847B1 (ko) 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
EP2956135B1 (fr) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7

Also Published As

Publication number Publication date
CN104066737B (zh) 2016-06-08
PL2804865T3 (pl) 2016-06-30
EP2804865A1 (fr) 2014-11-26
KR20140112567A (ko) 2014-09-23
BR112014017735A2 (pt) 2017-06-27
CA2863228C (fr) 2020-07-21
PH12014501415A1 (en) 2014-09-22
WO2013108227A1 (fr) 2013-07-25
EA024204B1 (ru) 2016-08-31
ZA201406085B (en) 2016-05-25
CN104066737A (zh) 2014-09-24
JP6111268B2 (ja) 2017-04-05
CL2014001772A1 (es) 2014-10-17
AR089753A1 (es) 2014-09-17
BR112014017735B1 (pt) 2022-06-28
TW201333013A (zh) 2013-08-16
NZ628910A (en) 2016-02-26
AU2013210682A1 (en) 2014-09-11
AU2013210682B2 (en) 2017-05-25
ES2563189T3 (es) 2016-03-11
MX336247B (es) 2016-01-13
BR112014017735A8 (pt) 2017-12-26
JP2015504086A (ja) 2015-02-05
US9409917B2 (en) 2016-08-09
SG11201403933UA (en) 2014-08-28
HK1203932A1 (en) 2015-11-06
US20150025075A1 (en) 2015-01-22
EP2804865B1 (fr) 2015-12-23
KR102033190B1 (ko) 2019-10-16
IL233662A0 (en) 2014-08-31
CA2863228A1 (fr) 2013-07-25
TWI576347B (zh) 2017-04-01
EA201400822A1 (ru) 2014-12-30
MX2014008736A (es) 2014-08-29

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