MA38679B1 - Modulateurs du récepteur de cxcr7 - Google Patents
Modulateurs du récepteur de cxcr7Info
- Publication number
- MA38679B1 MA38679B1 MA38679A MA38679A MA38679B1 MA 38679 B1 MA38679 B1 MA 38679B1 MA 38679 A MA38679 A MA 38679A MA 38679 A MA38679 A MA 38679A MA 38679 B1 MA38679 B1 MA 38679B1
- Authority
- MA
- Morocco
- Prior art keywords
- cxcr7
- modulators
- receiver modulators
- formula
- receiver
- Prior art date
Links
- 101150017558 ACKR3 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
L'invention concerne des dérivés de formule (i), dans laquelle (r1)n, r 2a, r 2b, r 3a, r 3b, r 4, l1, l2, x, y et ar1 sont tels que définis dans la description, ainsi que leur préparation, des sels pharmaceutiquement acceptables de ceux-ci et leur utilisation en tant que produits pharmaceutiques, des compositions pharmaceutiques contenant au moins un composé de formule (i), et en particulier leur utilisation en tant que modulateurs du récepteur de cxcr7
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013054478 | 2013-05-30 | ||
| PCT/IB2014/061774 WO2014191929A1 (fr) | 2013-05-30 | 2014-05-28 | Modulateurs du récepteur de cxcr7 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38679A1 MA38679A1 (fr) | 2018-07-31 |
| MA38679B1 true MA38679B1 (fr) | 2019-12-31 |
Family
ID=50943357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38679A MA38679B1 (fr) | 2013-05-30 | 2014-05-28 | Modulateurs du récepteur de cxcr7 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9920010B2 (fr) |
| EP (1) | EP3004082B1 (fr) |
| JP (1) | JP6393749B2 (fr) |
| KR (1) | KR102302580B1 (fr) |
| CN (1) | CN105263924B (fr) |
| AR (1) | AR096490A1 (fr) |
| AU (1) | AU2014272718B2 (fr) |
| BR (1) | BR112015030095B1 (fr) |
| CA (1) | CA2912133C (fr) |
| CL (1) | CL2015003470A1 (fr) |
| CY (1) | CY1119537T1 (fr) |
| DK (1) | DK3004082T3 (fr) |
| EA (1) | EA028604B1 (fr) |
| ES (1) | ES2645470T3 (fr) |
| HR (1) | HRP20171597T1 (fr) |
| HU (1) | HUE036649T2 (fr) |
| IL (1) | IL242782B (fr) |
| LT (1) | LT3004082T (fr) |
| MA (1) | MA38679B1 (fr) |
| MX (1) | MX364104B (fr) |
| MY (1) | MY173564A (fr) |
| NO (1) | NO3004082T3 (fr) |
| PH (1) | PH12015502632B1 (fr) |
| PL (1) | PL3004082T3 (fr) |
| PT (1) | PT3004082T (fr) |
| SG (1) | SG11201509057UA (fr) |
| SI (1) | SI3004082T1 (fr) |
| TW (1) | TWI640510B (fr) |
| UA (1) | UA118562C2 (fr) |
| WO (1) | WO2014191929A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR091516A1 (es) | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| CN107001279B (zh) | 2014-12-01 | 2020-10-20 | 爱杜西亚药品有限公司 | Cxcr7受体调节剂 |
| US20170112831A1 (en) * | 2015-10-23 | 2017-04-27 | James MERRITT | Use of ccr1 antagonists as a treatment for tumors of the central nervous system |
| NZ751006A (en) * | 2016-07-28 | 2021-07-30 | Idorsia Pharmaceuticals Ltd | Piperidine cxcr7 receptor modulators |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| HRP20211533T1 (hr) | 2017-05-18 | 2022-01-07 | Idorsia Pharmaceuticals Ltd | Derivati fenila kao modulatori receptora pge2 |
| MA51664B1 (fr) | 2018-01-26 | 2024-05-31 | Idorsia Pharmaceuticals Ltd | Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-([5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino)-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896170A (en) | 1969-02-26 | 1975-07-22 | American Home Prod | Intermediates for the preparation of 1,3-dihydro-2h-1, -benzodiazepin-2-ones |
| WO1999042456A2 (fr) | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Nouveaux composes et leur utilisation comme modulateurs positifs du recepteur ampa |
| GB9816984D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
| JP2004515494A (ja) | 2000-12-07 | 2004-05-27 | アストラゼネカ・アクチエボラーグ | 治療剤 |
| MXPA05006507A (es) | 2002-12-20 | 2006-02-17 | Chemocentryx | Inhibidores de ccxckr2 expresado en tumor humano. |
| ATE486875T1 (de) * | 2005-11-10 | 2010-11-15 | Chemocentryx Inc | Substituierte chinolone und verwendungsverfahren |
| US20100331298A1 (en) | 2007-12-10 | 2010-12-30 | Cytopathfinder, Inc. | Carboxamide Compounds and Their Use |
| AR091516A1 (es) * | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| CN107001279B (zh) | 2014-12-01 | 2020-10-20 | 爱杜西亚药品有限公司 | Cxcr7受体调节剂 |
-
2014
- 2014-05-28 WO PCT/IB2014/061774 patent/WO2014191929A1/fr not_active Ceased
- 2014-05-28 KR KR1020157036801A patent/KR102302580B1/ko not_active Expired - Fee Related
- 2014-05-28 PT PT147305916T patent/PT3004082T/pt unknown
- 2014-05-28 MX MX2015016429A patent/MX364104B/es active IP Right Grant
- 2014-05-28 CA CA2912133A patent/CA2912133C/fr active Active
- 2014-05-28 CN CN201480030766.2A patent/CN105263924B/zh not_active Expired - Fee Related
- 2014-05-28 MA MA38679A patent/MA38679B1/fr unknown
- 2014-05-28 UA UAA201512741A patent/UA118562C2/uk unknown
- 2014-05-28 EP EP14730591.6A patent/EP3004082B1/fr active Active
- 2014-05-28 SI SI201430415T patent/SI3004082T1/sl unknown
- 2014-05-28 US US14/892,959 patent/US9920010B2/en active Active
- 2014-05-28 MY MYPI2015704311A patent/MY173564A/en unknown
- 2014-05-28 HR HRP20171597TT patent/HRP20171597T1/hr unknown
- 2014-05-28 EA EA201501163A patent/EA028604B1/ru not_active IP Right Cessation
- 2014-05-28 ES ES14730591.6T patent/ES2645470T3/es active Active
- 2014-05-28 BR BR112015030095-2A patent/BR112015030095B1/pt not_active IP Right Cessation
- 2014-05-28 NO NO14730591A patent/NO3004082T3/no unknown
- 2014-05-28 PL PL14730591T patent/PL3004082T3/pl unknown
- 2014-05-28 DK DK14730591.6T patent/DK3004082T3/en active
- 2014-05-28 AU AU2014272718A patent/AU2014272718B2/en not_active Ceased
- 2014-05-28 JP JP2016516287A patent/JP6393749B2/ja not_active Expired - Fee Related
- 2014-05-28 SG SG11201509057UA patent/SG11201509057UA/en unknown
- 2014-05-28 LT LTEP14730591.6T patent/LT3004082T/lt unknown
- 2014-05-28 HU HUE14730591A patent/HUE036649T2/hu unknown
- 2014-05-29 TW TW103118884A patent/TWI640510B/zh not_active IP Right Cessation
- 2014-05-29 AR ARP140102121A patent/AR096490A1/es active IP Right Grant
-
2015
- 2015-11-25 IL IL242782A patent/IL242782B/en active IP Right Grant
- 2015-11-26 PH PH12015502632A patent/PH12015502632B1/en unknown
- 2015-11-27 CL CL2015003470A patent/CL2015003470A1/es unknown
-
2017
- 2017-11-02 CY CY20171101149T patent/CY1119537T1/el unknown
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