MX375978B - Derivados de indol n-sustituidos como moduladores de los receptores de pge2. - Google Patents

Derivados de indol n-sustituidos como moduladores de los receptores de pge2.

Info

Publication number
MX375978B
MX375978B MX2018005268A MX2018005268A MX375978B MX 375978 B MX375978 B MX 375978B MX 2018005268 A MX2018005268 A MX 2018005268A MX 2018005268 A MX2018005268 A MX 2018005268A MX 375978 B MX375978 B MX 375978B
Authority
MX
Mexico
Prior art keywords
sup
receptor modulators
pge2 receptor
substituted indol
indol derivatives
Prior art date
Application number
MX2018005268A
Other languages
English (en)
Other versions
MX2018005268A (es
Inventor
Davide Pozzi
Heinz Fretz
Isabelle Lyothier
Julien Pothier
Lorenza Wyder PETERS
Olivier Corminboeuf
Sylvia Richard-Bildstein
Thierry Sifferlen
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2018005268A publication Critical patent/MX2018005268A/es
Publication of MX375978B publication Critical patent/MX375978B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a derivados de la fórmula (I): (ver Fórmula) en donde (R1)n, R2, R3, R4a, R4b, R5a, R5b y Ar1 son como se describen en la descripción, a su preparación, a sales farmacéuticamente aceptables de los mismos, y a su uso como productos farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de la fórmula (I) y en especial a su uso como moduladores de los receptores de prostaglandina 2: EP2 y/o EP4.
MX2018005268A 2015-11-20 2016-11-17 Derivados de indol n-sustituidos como moduladores de los receptores de pge2. MX375978B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015077269 2015-11-20
PCT/EP2016/078028 WO2017085198A1 (en) 2015-11-20 2016-11-17 N-substituted indole derivatives as pge2 receptor modulators

Publications (2)

Publication Number Publication Date
MX2018005268A MX2018005268A (es) 2018-11-29
MX375978B true MX375978B (es) 2025-03-07

Family

ID=57326428

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005268A MX375978B (es) 2015-11-20 2016-11-17 Derivados de indol n-sustituidos como moduladores de los receptores de pge2.

Country Status (34)

Country Link
US (2) US11241431B2 (es)
EP (2) EP3377483B9 (es)
JP (2) JP2018534328A (es)
KR (1) KR102352022B1 (es)
CN (1) CN108349949B (es)
AU (1) AU2016358242B2 (es)
BR (1) BR112018010291B1 (es)
CA (1) CA3002610C (es)
CL (1) CL2018001325A1 (es)
CO (1) CO2018005715A2 (es)
CR (1) CR20180323A (es)
CY (1) CY1124913T1 (es)
DK (2) DK3928836T3 (es)
EA (1) EA037953B1 (es)
ES (2) ES2994636T3 (es)
FI (1) FI3928836T3 (es)
HR (2) HRP20211678T1 (es)
HU (2) HUE056679T2 (es)
IL (1) IL259424B (es)
LT (2) LT3377483T (es)
MA (2) MA43251B1 (es)
MX (1) MX375978B (es)
MY (1) MY195888A (es)
PE (1) PE20181304A1 (es)
PH (1) PH12018501077B1 (es)
PL (2) PL3377483T3 (es)
PT (2) PT3928836T (es)
RS (2) RS66179B1 (es)
SA (1) SA518391588B1 (es)
SG (1) SG11201803627XA (es)
SI (2) SI3377483T1 (es)
TW (2) TWI719078B (es)
UA (1) UA123441C2 (es)
WO (1) WO2017085198A1 (es)

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