CY1123185T1 - Παραγωγα ινδολιου - Google Patents

Παραγωγα ινδολιου

Info

Publication number
CY1123185T1
CY1123185T1 CY20201100739T CY201100739T CY1123185T1 CY 1123185 T1 CY1123185 T1 CY 1123185T1 CY 20201100739 T CY20201100739 T CY 20201100739T CY 201100739 T CY201100739 T CY 201100739T CY 1123185 T1 CY1123185 T1 CY 1123185T1
Authority
CY
Cyprus
Prior art keywords
compounds
indole derivatives
general formula
well
relates
Prior art date
Application number
CY20201100739T
Other languages
English (en)
Inventor
Gyula Beke
János ÉLES
András BOROS
Sándor FARKAS
György Miklós Keserü
Original Assignee
Richter Gedeon Nyrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt. filed Critical Richter Gedeon Nyrt.
Publication of CY1123185T1 publication Critical patent/CY1123185T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με ενώσεις του γενικού τύπου (Ι). Η παρούσα εφεύρεση σχετίζεται με νέα υποκατεστημένα διαζεπινο-ινδολικά παράγωγα του γενικού τύπου (Ι), και με φαρμακευτικώς αποδεκτά άλατα αυτών, όπως επίσης και με φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις, με νέες ενδιάμεσες ενώσεις αυτών, όπως επίσης και με τη χρήση τέτοιων ενώσεων για τη θεραπεία ή την πρόληψη διαταραχών που σχετίζονται με δραστικότητα υποδοχέα 1 μελανοστατίνης.
CY20201100739T 2015-04-15 2020-08-06 Παραγωγα ινδολιου CY1123185T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1500169A HU230880B1 (hu) 2015-04-15 2015-04-15 Indol származékok
PCT/IB2016/052110 WO2016166684A1 (en) 2015-04-15 2016-04-14 Indole derivatives

Publications (1)

Publication Number Publication Date
CY1123185T1 true CY1123185T1 (el) 2021-10-29

Family

ID=89991787

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100739T CY1123185T1 (el) 2015-04-15 2020-08-06 Παραγωγα ινδολιου

Country Status (35)

Country Link
US (1) US10329296B2 (el)
EP (1) EP3286193B1 (el)
JP (1) JP6783793B2 (el)
KR (1) KR102591750B1 (el)
CN (1) CN107466294B (el)
AR (1) AR104261A1 (el)
AU (1) AU2016248969B2 (el)
CA (1) CA2982232C (el)
CL (1) CL2017002605A1 (el)
CO (1) CO2017011511A2 (el)
CU (1) CU24451B1 (el)
CY (1) CY1123185T1 (el)
DK (1) DK3286193T3 (el)
EA (1) EA034427B1 (el)
ES (1) ES2804519T3 (el)
GE (1) GEP20207067B (el)
HK (1) HK1243705A1 (el)
HR (1) HRP20201289T1 (el)
HU (2) HU230880B1 (el)
IL (1) IL254711B (el)
LT (1) LT3286193T (el)
MX (1) MX2017013201A (el)
MY (1) MY189372A (el)
PE (1) PE20180196A1 (el)
PH (1) PH12017501736A1 (el)
PL (1) PL3286193T3 (el)
PT (1) PT3286193T (el)
RS (1) RS60605B1 (el)
SA (1) SA517390161B1 (el)
SG (1) SG11201707772RA (el)
SI (1) SI3286193T1 (el)
TW (1) TWI703145B (el)
UA (1) UA121046C2 (el)
UY (1) UY36608A (el)
WO (1) WO2016166684A1 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP2200222A1 (hu) 2022-06-17 2023-12-28 Richter Gedeon Nyrt MCHR1 antagonisták a Prader-Willi szindróma kezelésére
HUP2200221A1 (hu) 2022-06-17 2023-12-28 Richter Gedeon Nyrt 4-[(5-klór-piridin-2-il)metoxi]-1-[3-(propán-2-il)-1H,2H,3H,4H,5H-[1,4]diazepino [1,7-a]indol-9-il]-1,2-dihidropiridin-2-on kristályos formái és ezek sói, valamint elõállításuk és alkalmazásuk

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8500370A (nl) * 1984-02-22 1985-09-16 Sandoz Ag Diazepinoindolen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
NZ521389A (en) * 2000-03-14 2005-06-24 Upjohn Co 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole compounds
AU2004266228A1 (en) 2003-08-13 2005-03-03 Amgen, Inc. Melanin concentrating hormone receptor antagonists
JPWO2007018248A1 (ja) 2005-08-10 2009-02-19 萬有製薬株式会社 ピリドン化合物
EP2142554B1 (en) 2007-04-25 2015-01-14 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists
JP5514716B2 (ja) 2007-05-11 2014-06-04 コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
CA2727055C (en) * 2008-01-11 2016-12-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
SA110310332B1 (ar) 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
EP2437599A4 (en) * 2009-06-03 2012-10-31 Glaxosmithkline Llc BIS-PYRIDYLPYRIDONE AS MELANIN CONCENTRATION HORMONE RECEPTOR-1 ANTAGONISTS
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011127643A1 (en) 2010-04-12 2011-10-20 Merck Sharp & Dohme Corp. Pyridone derivatives
EP2558094A4 (en) 2010-04-12 2013-09-25 Merck Sharp & Dohme PYRIDONE DERIVATIVES
US8993765B2 (en) * 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US8933079B2 (en) 2012-03-07 2015-01-13 Boehringer Ingelheim International Gmbh Pyridone and pyridazinone derivatives as anti-obesity agents
WO2013149362A1 (en) 2012-04-06 2013-10-10 Glaxosmithkline Llc 1-(dihydronaphthalenyl)pyridones as melanin-concentrating hormone receptor 1 antagonists
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US20140163012A1 (en) 2012-12-11 2014-06-12 Albany Molecular Research, Inc. Pyrido-/azepino-benzofuran and pyrido-/azepino-benzothiophene mch-1 antagonists, methods of making, and use thereof

Also Published As

Publication number Publication date
EA034427B1 (ru) 2020-02-06
GEP20207067B (en) 2020-02-10
AU2016248969A1 (en) 2017-11-09
EA201792170A1 (ru) 2018-03-30
PE20180196A1 (es) 2018-01-26
AU2016248969B2 (en) 2020-03-12
UA121046C2 (uk) 2020-03-25
HRP20201289T1 (hr) 2020-11-13
IL254711B (en) 2021-06-30
CU20170128A7 (es) 2018-01-10
RS60605B1 (sr) 2020-08-31
CO2017011511A2 (es) 2017-11-21
TW201708226A (zh) 2017-03-01
IL254711A0 (en) 2017-11-30
EP3286193B1 (en) 2020-05-27
JP6783793B2 (ja) 2020-11-11
US10329296B2 (en) 2019-06-25
PH12017501736A1 (en) 2018-03-12
CA2982232C (en) 2023-03-28
TWI703145B (zh) 2020-09-01
CN107466294B (zh) 2020-01-17
LT3286193T (lt) 2020-08-10
KR20170137130A (ko) 2017-12-12
PT3286193T (pt) 2020-08-26
BR112017021843A2 (pt) 2018-07-10
WO2016166684A1 (en) 2016-10-20
JP2018511637A (ja) 2018-04-26
GEAP201914624A (el) 2019-10-10
MY189372A (en) 2022-02-08
HUE16718017T2 (hu) 2021-03-29
AR104261A1 (es) 2017-07-05
CU24451B1 (es) 2019-11-04
PL3286193T3 (pl) 2020-11-16
CN107466294A (zh) 2017-12-12
EP3286193A1 (en) 2018-02-28
HK1243705A1 (zh) 2018-07-20
ES2804519T3 (es) 2021-02-08
CA2982232A1 (en) 2016-10-20
DK3286193T3 (da) 2020-08-24
HU230880B1 (hu) 2018-11-29
SI3286193T1 (sl) 2020-10-30
UY36608A (es) 2016-09-30
KR102591750B1 (ko) 2023-10-19
CL2017002605A1 (es) 2018-03-16
SA517390161B1 (ar) 2021-07-12
US20180093989A1 (en) 2018-04-05
MX2017013201A (es) 2018-02-09
HUP1500169A2 (en) 2016-10-28
SG11201707772RA (en) 2017-10-30

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