UY36608A - Derivados de indol - Google Patents

Derivados de indol

Info

Publication number
UY36608A
UY36608A UY0001036608A UY36608A UY36608A UY 36608 A UY36608 A UY 36608A UY 0001036608 A UY0001036608 A UY 0001036608A UY 36608 A UY36608 A UY 36608A UY 36608 A UY36608 A UY 36608A
Authority
UY
Uruguay
Prior art keywords
compounds
general formula
well
relates
present
Prior art date
Application number
UY0001036608A
Other languages
English (en)
Inventor
Dr Beke Gyula
Dr Éles János
Dr Boros András
Dr Farkas Sándor
Dr Keseru György Miklós
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of UY36608A publication Critical patent/UY36608A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se relaciona con compuestos de la fórmula general (I),La presente invención se relaciona con nuevos derivados de diazepino-indol sustituido de la fórmula general (I), y con sales farmacéuticamente aceptable de los mismos, así como también con composiciones farmacéuticas que comprenden dichos compuestos, con nuevos intermedios de los mismos, así como también con el uso de dichos compuestos en tratamiento o prevención de trastornos asociados con actividad receptora de hormona que concentra melanina.
UY0001036608A 2015-04-15 2016-04-06 Derivados de indol UY36608A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1500169A HU230880B1 (hu) 2015-04-15 2015-04-15 Indol származékok

Publications (1)

Publication Number Publication Date
UY36608A true UY36608A (es) 2016-09-30

Family

ID=89991787

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036608A UY36608A (es) 2015-04-15 2016-04-06 Derivados de indol

Country Status (36)

Country Link
US (1) US10329296B2 (es)
EP (1) EP3286193B1 (es)
JP (1) JP6783793B2 (es)
KR (1) KR102591750B1 (es)
CN (1) CN107466294B (es)
AR (1) AR104261A1 (es)
AU (1) AU2016248969B2 (es)
CA (1) CA2982232C (es)
CL (1) CL2017002605A1 (es)
CO (1) CO2017011511A2 (es)
CU (1) CU24451B1 (es)
CY (1) CY1123185T1 (es)
DK (1) DK3286193T3 (es)
EA (1) EA034427B1 (es)
ES (1) ES2804519T3 (es)
GE (1) GEP20207067B (es)
HK (1) HK1243705A1 (es)
HR (1) HRP20201289T1 (es)
HU (2) HU230880B1 (es)
IL (1) IL254711B (es)
LT (1) LT3286193T (es)
MX (1) MX2017013201A (es)
MY (1) MY189372A (es)
NZ (1) NZ736551A (es)
PE (1) PE20180196A1 (es)
PH (1) PH12017501736A1 (es)
PL (1) PL3286193T3 (es)
PT (1) PT3286193T (es)
RS (1) RS60605B1 (es)
SA (1) SA517390161B1 (es)
SG (1) SG11201707772RA (es)
SI (1) SI3286193T1 (es)
TW (1) TWI703145B (es)
UA (1) UA121046C2 (es)
UY (1) UY36608A (es)
WO (1) WO2016166684A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP2200221A1 (hu) 2022-06-17 2023-12-28 Richter Gedeon Nyrt 4-[(5-klór-piridin-2-il)metoxi]-1-[3-(propán-2-il)-1H,2H,3H,4H,5H-[1,4]diazepino [1,7-a]indol-9-il]-1,2-dihidropiridin-2-on kristályos formái és ezek sói, valamint elõállításuk és alkalmazásuk
HUP2200222A1 (hu) 2022-06-17 2023-12-28 Richter Gedeon Nyrt MCHR1 antagonisták a Prader-Willi szindróma kezelésére

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8500370A (nl) * 1984-02-22 1985-09-16 Sandoz Ag Diazepinoindolen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
WO2001072752A2 (en) * 2000-03-14 2001-10-04 Pharmacia & Upjohn Company 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-a]INDOLE COMPOUNDS
MXPA06001638A (es) 2003-08-13 2006-04-28 Amgen Inc Antagonistas del receptor de la hormona concentradora de melanina.
CA2618112A1 (en) 2005-08-10 2007-02-15 Banyu Pharmaceutical Co., Ltd. Pyridone compound
WO2008134480A1 (en) 2007-04-25 2008-11-06 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists
US8198307B2 (en) 2007-05-11 2012-06-12 Korea Research Institute Of Chemical Technology Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
ES2523580T3 (es) * 2008-01-11 2014-11-27 Albany Molecular Research, Inc. Piridoindoles substituidos con (1-Azinona)
SA110310332B1 (ar) 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
US20120083489A1 (en) * 2009-06-03 2012-04-05 Christensen Iv Siegfried Benjamin Bis-pyridylpyridones as melanin-concentrating hormone receptor antagonists
JP2012532144A (ja) * 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ， インコーポレイテッド アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
WO2011127643A1 (en) * 2010-04-12 2011-10-20 Merck Sharp & Dohme Corp. Pyridone derivatives
US20120316200A1 (en) * 2010-04-12 2012-12-13 Merck Sharp & Dohme Corp. Pyridone derivatives
US8993765B2 (en) * 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US8933079B2 (en) 2012-03-07 2015-01-13 Boehringer Ingelheim International Gmbh Pyridone and pyridazinone derivatives as anti-obesity agents
WO2013149362A1 (en) 2012-04-06 2013-10-10 Glaxosmithkline Llc 1-(dihydronaphthalenyl)pyridones as melanin-concentrating hormone receptor 1 antagonists
US9586900B2 (en) 2012-09-05 2017-03-07 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
US20140163012A1 (en) * 2012-12-11 2014-06-12 Albany Molecular Research, Inc. Pyrido-/azepino-benzofuran and pyrido-/azepino-benzothiophene mch-1 antagonists, methods of making, and use thereof

Also Published As

Publication number Publication date
NZ736551A (en) 2024-08-30
US10329296B2 (en) 2019-06-25
SI3286193T1 (sl) 2020-10-30
EP3286193B1 (en) 2020-05-27
HK1243705A1 (zh) 2018-07-20
CA2982232A1 (en) 2016-10-20
EA201792170A1 (ru) 2018-03-30
WO2016166684A1 (en) 2016-10-20
PT3286193T (pt) 2020-08-26
HU230880B1 (hu) 2018-11-29
IL254711A0 (en) 2017-11-30
HUP1500169A2 (en) 2016-10-28
DK3286193T3 (da) 2020-08-24
JP6783793B2 (ja) 2020-11-11
UA121046C2 (uk) 2020-03-25
CA2982232C (en) 2023-03-28
SG11201707772RA (en) 2017-10-30
MY189372A (en) 2022-02-08
SA517390161B1 (ar) 2021-07-12
TWI703145B (zh) 2020-09-01
PH12017501736A1 (en) 2018-03-12
AR104261A1 (es) 2017-07-05
CO2017011511A2 (es) 2017-11-21
AU2016248969A1 (en) 2017-11-09
CL2017002605A1 (es) 2018-03-16
GEP20207067B (en) 2020-02-10
KR20170137130A (ko) 2017-12-12
KR102591750B1 (ko) 2023-10-19
HUE16718017T2 (hu) 2021-03-29
GEAP201914624A (es) 2019-10-10
PE20180196A1 (es) 2018-01-26
CU20170128A7 (es) 2018-01-10
LT3286193T (lt) 2020-08-10
IL254711B (en) 2021-06-30
EP3286193A1 (en) 2018-02-28
HRP20201289T1 (hr) 2020-11-13
ES2804519T3 (es) 2021-02-08
AU2016248969B2 (en) 2020-03-12
US20180093989A1 (en) 2018-04-05
RS60605B1 (sr) 2020-08-31
BR112017021843A2 (pt) 2018-07-10
CY1123185T1 (el) 2021-10-29
JP2018511637A (ja) 2018-04-26
CN107466294A (zh) 2017-12-12
EA034427B1 (ru) 2020-02-06
CU24451B1 (es) 2019-11-04
TW201708226A (zh) 2017-03-01
CN107466294B (zh) 2020-01-17
MX2017013201A (es) 2018-02-09
PL3286193T3 (pl) 2020-11-16

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Legal Events

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Effective date: 20240607