UY35276A - Nuevos compuestos que inhiben la actividad de Lp-PLA2 - Google Patents

Nuevos compuestos que inhiben la actividad de Lp-PLA2

Info

Publication number
UY35276A
UY35276A UY0001035276A UY35276A UY35276A UY 35276 A UY35276 A UY 35276A UY 0001035276 A UY0001035276 A UY 0001035276A UY 35276 A UY35276 A UY 35276A UY 35276 A UY35276 A UY 35276A
Authority
UY
Uruguay
Prior art keywords
pla2
activity
inhibit
new compounds
procedures
Prior art date
Application number
UY0001035276A
Other languages
English (en)
Inventor
Wan Zehong
Zhang Qing
Sang Yingxia
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50002724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY35276(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of UY35276A publication Critical patent/UY35276A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención se refiere a nuevos compuestos que inhiben la actividad de Lp-PLA2, a procedi mientos para su preparación, a procedimientos para su preparación, a composiciones que los contiene n y a su uso en el tratamiento de enfermedades asociadas con la actividad de Lp-PLA2, por ejemplo a terosclerosis, enfermedad de Alzheimer.
UY0001035276A 2013-01-25 2014-01-23 Nuevos compuestos que inhiben la actividad de Lp-PLA2 UY35276A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013070976 2013-01-25
CN2013001556 2013-12-12

Publications (1)

Publication Number Publication Date
UY35276A true UY35276A (es) 2014-08-29

Family

ID=50002724

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035276A UY35276A (es) 2013-01-25 2014-01-23 Nuevos compuestos que inhiben la actividad de Lp-PLA2

Country Status (23)

Country Link
US (1) US9708330B2 (es)
EP (1) EP2948452B1 (es)
JP (1) JP6306053B2 (es)
KR (1) KR20150108897A (es)
CN (1) CN105008368B (es)
AU (1) AU2014209949B2 (es)
BR (1) BR112015017759B1 (es)
CA (1) CA2899091A1 (es)
CL (1) CL2015002060A1 (es)
CR (1) CR20150390A (es)
EA (1) EA025885B1 (es)
ES (1) ES2642762T3 (es)
HK (1) HK1216425A1 (es)
IL (1) IL240046A0 (es)
MA (1) MA38284B1 (es)
MX (1) MX2015009633A (es)
PE (1) PE20151251A1 (es)
PH (1) PH12015501586A1 (es)
SG (1) SG11201505520WA (es)
TW (1) TW201443054A (es)
UY (1) UY35276A (es)
WO (1) WO2014114694A1 (es)
ZA (1) ZA201505025B (es)

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CN105008368B (zh) 2013-01-25 2017-02-01 葛兰素史密斯克莱知识产权发展有限公司 基于2,3‑二氢咪唑并[1,2‑c]嘧啶‑5(1H)‑酮的脂蛋白相关磷脂酶A2(Lp‑PLA2)抑制剂
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CN104892459A (zh) * 2015-06-16 2015-09-09 苏州明锐医药科技有限公司 利奥西呱中间体及其制备方法
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
CA3156783A1 (en) * 2019-11-09 2021-05-14 Yun Jin Tricycle dihydroimidazopyrimidone derivative, preparation method thereof, pharmaceutical composition and use thereof
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
CN113861220B (zh) * 2020-06-30 2023-06-16 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
CN114057740B (zh) * 2021-12-15 2024-04-02 上海赛默罗生物科技有限公司 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途
CN116120329A (zh) * 2022-08-04 2023-05-16 福贝生物医药科技(北京)有限公司 作为Lp-PLA2抑制剂的新型化合物及其用途

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KR20140059203A (ko) * 2011-07-27 2014-05-15 글락소 그룹 리미티드 2,3-디히드로이미다조[1,2-c]피리미딘-5(1h)-온 화합물의 lp-pla2 억제제로서의 용도
CN105008368B (zh) 2013-01-25 2017-02-01 葛兰素史密斯克莱知识产权发展有限公司 基于2,3‑二氢咪唑并[1,2‑c]嘧啶‑5(1H)‑酮的脂蛋白相关磷脂酶A2(Lp‑PLA2)抑制剂

Also Published As

Publication number Publication date
ES2642762T3 (es) 2017-11-20
WO2014114694A1 (en) 2014-07-31
BR112015017759A2 (pt) 2017-07-11
IL240046A0 (en) 2015-08-31
JP6306053B2 (ja) 2018-04-04
JP2016505058A (ja) 2016-02-18
EP2948452A1 (en) 2015-12-02
CR20150390A (es) 2015-10-19
EA201591379A1 (ru) 2016-01-29
TW201443054A (zh) 2014-11-16
EA025885B1 (ru) 2017-02-28
SG11201505520WA (en) 2015-08-28
AU2014209949A1 (en) 2015-07-30
MX2015009633A (es) 2015-11-30
HK1216425A1 (zh) 2016-11-11
BR112015017759B1 (pt) 2022-05-24
KR20150108897A (ko) 2015-09-30
US20150361082A1 (en) 2015-12-17
MA38284B1 (fr) 2018-05-31
CN105008368B (zh) 2017-02-01
PE20151251A1 (es) 2015-09-10
CN105008368A (zh) 2015-10-28
CL2015002060A1 (es) 2015-11-27
US9708330B2 (en) 2017-07-18
ZA201505025B (en) 2017-08-30
CA2899091A1 (en) 2014-07-31
PH12015501586A1 (en) 2015-10-05
EP2948452B1 (en) 2017-08-09
AU2014209949B2 (en) 2016-09-08
MA38284A1 (fr) 2017-12-29

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Effective date: 20211028