MX2015009633A - Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona. - Google Patents

Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona.

Info

Publication number
MX2015009633A
MX2015009633A MX2015009633A MX2015009633A MX2015009633A MX 2015009633 A MX2015009633 A MX 2015009633A MX 2015009633 A MX2015009633 A MX 2015009633A MX 2015009633 A MX2015009633 A MX 2015009633A MX 2015009633 A MX2015009633 A MX 2015009633A
Authority
MX
Mexico
Prior art keywords
pla2
dihydroimidazol
pyrimidin
inhibitors
associated phospholipase
Prior art date
Application number
MX2015009633A
Other languages
English (en)
Inventor
Zehong Wan
Yingxia Sang
Qing Zhang
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50002724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015009633(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MX2015009633A publication Critical patent/MX2015009633A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a nuevos compuestos que inhiben la actividad de Lp-PLA2, a procedimientos para su preparación, a composiciones que los contienen y a su uso en el tratamiento de enfermedades asociadas con la actividad de Lp-PLA2, por ejemplo aterosclerosis, enfermedad de Alzheimer.
MX2015009633A 2013-01-25 2014-01-23 Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona. MX2015009633A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2013070976 2013-01-25
CN2013001556 2013-12-12
PCT/EP2014/051286 WO2014114694A1 (en) 2013-01-25 2014-01-23 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors

Publications (1)

Publication Number Publication Date
MX2015009633A true MX2015009633A (es) 2015-11-30

Family

ID=50002724

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015009633A MX2015009633A (es) 2013-01-25 2014-01-23 Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona.

Country Status (23)

Country Link
US (1) US9708330B2 (es)
EP (1) EP2948452B1 (es)
JP (1) JP6306053B2 (es)
KR (1) KR20150108897A (es)
CN (1) CN105008368B (es)
AU (1) AU2014209949B2 (es)
BR (1) BR112015017759B1 (es)
CA (1) CA2899091A1 (es)
CL (1) CL2015002060A1 (es)
CR (1) CR20150390A (es)
EA (1) EA025885B1 (es)
ES (1) ES2642762T3 (es)
HK (1) HK1216425A1 (es)
IL (1) IL240046A0 (es)
MA (1) MA38284B1 (es)
MX (1) MX2015009633A (es)
PE (1) PE20151251A1 (es)
PH (1) PH12015501586A1 (es)
SG (1) SG11201505520WA (es)
TW (1) TW201443054A (es)
UY (1) UY35276A (es)
WO (1) WO2014114694A1 (es)
ZA (1) ZA201505025B (es)

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SG11201505520WA (en) 2013-01-25 2015-08-28 Glaxosmithkline Ip Dev Ltd 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA<sb>2</sb>) INHIBITORS
EP3172211B1 (en) 2014-07-22 2019-07-03 GlaxoSmithKline Intellectual Property Development Limited Tricyclic imidazo-pyrimidinone derivatives for the treatment of diseases mediated by lp-pla2
WO2016012917A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN104892459A (zh) * 2015-06-16 2015-09-09 苏州明锐医药科技有限公司 利奥西呱中间体及其制备方法
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
AU2020379796C1 (en) 2019-11-09 2024-05-02 Shanghai SIMR Biotechnology Co., Ltd Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
CN113861220B (zh) * 2020-06-30 2023-06-16 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN113912622B (zh) 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
CN114057740B (zh) * 2021-12-15 2024-04-02 上海赛默罗生物科技有限公司 螺环嘧啶酮衍生物、其制备方法、药物组合物和用途
CN116120329A (zh) * 2022-08-04 2023-05-16 福贝生物医药科技(北京)有限公司 作为Lp-PLA2抑制剂的新型化合物及其用途

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Also Published As

Publication number Publication date
MA38284A1 (fr) 2017-12-29
ZA201505025B (en) 2017-08-30
IL240046A0 (en) 2015-08-31
KR20150108897A (ko) 2015-09-30
ES2642762T3 (es) 2017-11-20
US9708330B2 (en) 2017-07-18
TW201443054A (zh) 2014-11-16
EA201591379A1 (ru) 2016-01-29
AU2014209949B2 (en) 2016-09-08
EP2948452B1 (en) 2017-08-09
HK1216425A1 (zh) 2016-11-11
AU2014209949A1 (en) 2015-07-30
CN105008368B (zh) 2017-02-01
BR112015017759A2 (pt) 2017-07-11
CA2899091A1 (en) 2014-07-31
PH12015501586A1 (en) 2015-10-05
JP2016505058A (ja) 2016-02-18
EP2948452A1 (en) 2015-12-02
BR112015017759B1 (pt) 2022-05-24
JP6306053B2 (ja) 2018-04-04
WO2014114694A1 (en) 2014-07-31
PE20151251A1 (es) 2015-09-10
UY35276A (es) 2014-08-29
CR20150390A (es) 2015-10-19
EA025885B1 (ru) 2017-02-28
MA38284B1 (fr) 2018-05-31
CL2015002060A1 (es) 2015-11-27
US20150361082A1 (en) 2015-12-17
CN105008368A (zh) 2015-10-28
SG11201505520WA (en) 2015-08-28

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