EA201891067A1 - [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИН-7-ИЛЬНОЕ СОЕДИНЕНИЕ - Google Patents
[1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИН-7-ИЛЬНОЕ СОЕДИНЕНИЕInfo
- Publication number
- EA201891067A1 EA201891067A1 EA201891067A EA201891067A EA201891067A1 EA 201891067 A1 EA201891067 A1 EA 201891067A1 EA 201891067 A EA201891067 A EA 201891067A EA 201891067 A EA201891067 A EA 201891067A EA 201891067 A1 EA201891067 A1 EA 201891067A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- triazolo
- compound
- ily
- pyrimidin
- pde2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Настоящее изобретение относится к новому [1,2,4]триазоло[1,5-a]пиримидинильному производному в качестве ингибитора фосфодиэстеразы 2 (PDE2). Настоящее изобретение также относится к фармацевтическим композициям, содержащим соединение, способам получения таких соединения и композиций и применению таких соединения и композиций для предупреждения и лечения расстройств, в которые вовлечена PDE2, таких как неврологические и психические расстройства.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15192661 | 2015-11-02 | ||
EP15192966 | 2015-11-04 | ||
PCT/EP2016/076420 WO2017076900A1 (en) | 2015-11-02 | 2016-11-02 | [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-7-YL COMPOUND |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201891067A1 true EA201891067A1 (ru) | 2018-10-31 |
EA036851B1 EA036851B1 (ru) | 2020-12-28 |
Family
ID=57256277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891067A EA036851B1 (ru) | 2015-11-02 | 2016-11-02 | [1,2,4]триазоло[1,5-a]пиримидин-7-ильное соединение |
Country Status (20)
Country | Link |
---|---|
US (1) | US10947239B2 (ru) |
EP (1) | EP3371188B1 (ru) |
JP (1) | JP6872541B2 (ru) |
KR (1) | KR20180075630A (ru) |
CN (1) | CN108349979B (ru) |
AU (1) | AU2016348549B2 (ru) |
BR (1) | BR112018008431A2 (ru) |
CA (1) | CA3001768C (ru) |
CO (1) | CO2018005163A2 (ru) |
EA (1) | EA036851B1 (ru) |
ES (1) | ES2765738T3 (ru) |
HK (1) | HK1256751A1 (ru) |
IL (1) | IL259004B (ru) |
MX (1) | MX2018005342A (ru) |
MY (1) | MY194700A (ru) |
PH (1) | PH12018500944A1 (ru) |
SG (1) | SG11201803605YA (ru) |
UA (1) | UA122423C2 (ru) |
WO (1) | WO2017076900A1 (ru) |
ZA (1) | ZA201802842B (ru) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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MA53944A (fr) | 2014-08-28 | 2021-08-25 | Asceneuron Sa | Inhibiteurs de la glycosidase |
BR112018008431A2 (pt) | 2015-11-02 | 2018-11-06 | Janssen Pharmaceutica Nv | composto de [1,2,4]triazolo[1,5-a]pirimidin-7-il |
EP3419971B1 (en) | 2016-02-25 | 2022-04-20 | Asceneuron SA | Glycosidase inhibitors |
MA43680A (fr) | 2016-02-25 | 2018-11-28 | Asceneuron Sa | Inhibiteurs de glycosidases |
AU2017222962B2 (en) | 2016-02-25 | 2021-03-25 | Asceneuron S. A. | Acid addition salts of piperazine derivatives |
US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
SG11201903892UA (en) * | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
ES2855032T3 (es) | 2016-11-02 | 2021-09-23 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
AU2017353313C1 (en) | 2016-11-02 | 2022-06-09 | Janssen Pharmaceutica Nv | (1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors |
EP3555094A1 (en) | 2016-12-16 | 2019-10-23 | Janssen Pharmaceutica NV | Bicyclic oga inhibitor compounds |
EP3672959A1 (en) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Linear glycosidase inhibitors |
WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
CN114605416B (zh) * | 2020-12-08 | 2023-12-01 | 奥锐特药业(天津)有限公司 | 阿卡替尼晶型i的制备方法 |
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AU676993B2 (en) | 1991-06-27 | 1997-04-10 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
KR20010034442A (ko) | 1998-01-27 | 2001-04-25 | 아벤티스 파마슈티칼즈 프로덕츠 인코포레이티드 | 치환된 옥소아자헤테로사이클릴 인자 Xa 억제제 |
US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
US20040014744A1 (en) | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
KR20050047132A (ko) | 2002-10-03 | 2005-05-19 | 버텍스 파마슈티칼스 인코포레이티드 | 신경계 질환 치료용 피페라진 및 피페리딘 유도체 |
EP1644003A1 (en) * | 2003-06-04 | 2006-04-12 | Vernalis (Cambridge) Limited | Triazolo ´1,5-a!pyrimidines and their use in medicine |
JP2007526894A (ja) | 2003-07-16 | 2007-09-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | グリコーゲンシンターゼキナーゼ3インヒビターとしてのトリアゾロピリミジン誘導体 |
WO2005063738A1 (ja) | 2003-12-29 | 2005-07-14 | Banyu Pharmaceutical Co.,Ltd | 新規2-へテロアリール置換ベンズイミダゾール誘導体 |
AU2005286731A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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JP2007332061A (ja) | 2006-06-14 | 2007-12-27 | Nippon Kayaku Co Ltd | 新規ピラゾロ[1,5−a]ピリミジン誘導体及びその用途 |
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MX344600B (es) * | 2011-06-27 | 2016-12-20 | Janssen Pharmaceutica Nv | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina. |
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TR201808280T4 (tr) | 2012-03-09 | 2018-07-23 | Lexicon Pharmaceuticals Inc | Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. |
KR102313353B1 (ko) * | 2013-07-29 | 2021-10-18 | 삼성전자주식회사 | 캐릭터 입력 방법 및 디스플레이 장치 |
JP6577479B2 (ja) | 2014-02-27 | 2019-09-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Nav チャンネル阻害剤としてのヘテロ環化合物及びその使用 |
EP3119765B1 (en) | 2014-03-19 | 2019-07-17 | Boehringer Ingelheim International GmbH | Heteroaryl syk inhibitors |
MA50375A (fr) * | 2014-04-23 | 2021-05-26 | Dart Neuroscience Cayman Ltd | Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2 |
CN105566321B (zh) | 2014-10-29 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
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WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
US20180305334A1 (en) | 2015-10-14 | 2018-10-25 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
BR112018008431A2 (pt) | 2015-11-02 | 2018-11-06 | Janssen Pharmaceutica Nv | composto de [1,2,4]triazolo[1,5-a]pirimidin-7-il |
WO2017157882A1 (en) | 2016-03-14 | 2017-09-21 | Université Catholique de Louvain | Serine biosynthetic pathway inhibitors |
SG11201903892UA (en) | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
ES2855032T3 (es) | 2016-11-02 | 2021-09-23 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
AU2017353313C1 (en) | 2016-11-02 | 2022-06-09 | Janssen Pharmaceutica Nv | (1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors |
EP3555094A1 (en) | 2016-12-16 | 2019-10-23 | Janssen Pharmaceutica NV | Bicyclic oga inhibitor compounds |
-
2016
- 2016-11-02 BR BR112018008431-0A patent/BR112018008431A2/pt not_active Application Discontinuation
- 2016-11-02 CA CA3001768A patent/CA3001768C/en active Active
- 2016-11-02 ES ES16793800T patent/ES2765738T3/es active Active
- 2016-11-02 JP JP2018521971A patent/JP6872541B2/ja active Active
- 2016-11-02 UA UAA201806063A patent/UA122423C2/uk unknown
- 2016-11-02 KR KR1020187015072A patent/KR20180075630A/ko not_active Application Discontinuation
- 2016-11-02 MY MYPI2018000611A patent/MY194700A/en unknown
- 2016-11-02 MX MX2018005342A patent/MX2018005342A/es active IP Right Grant
- 2016-11-02 SG SG11201803605YA patent/SG11201803605YA/en unknown
- 2016-11-02 EP EP16793800.0A patent/EP3371188B1/en active Active
- 2016-11-02 AU AU2016348549A patent/AU2016348549B2/en not_active Ceased
- 2016-11-02 US US15/772,859 patent/US10947239B2/en active Active
- 2016-11-02 EA EA201891067A patent/EA036851B1/ru unknown
- 2016-11-02 WO PCT/EP2016/076420 patent/WO2017076900A1/en active Application Filing
- 2016-11-02 CN CN201680063119.0A patent/CN108349979B/zh active Active
-
2018
- 2018-04-29 IL IL259004A patent/IL259004B/en active IP Right Grant
- 2018-04-30 ZA ZA2018/02842A patent/ZA201802842B/en unknown
- 2018-05-02 PH PH12018500944A patent/PH12018500944A1/en unknown
- 2018-05-16 CO CONC2018/0005163A patent/CO2018005163A2/es unknown
- 2018-12-11 HK HK18115831.1A patent/HK1256751A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
PH12018500944B1 (en) | 2018-11-19 |
IL259004B (en) | 2021-06-30 |
BR112018008431A2 (pt) | 2018-11-06 |
EP3371188B1 (en) | 2019-10-23 |
US20180327408A1 (en) | 2018-11-15 |
JP2018535968A (ja) | 2018-12-06 |
CN108349979A (zh) | 2018-07-31 |
KR20180075630A (ko) | 2018-07-04 |
UA122423C2 (uk) | 2020-11-10 |
AU2016348549B2 (en) | 2020-07-23 |
ES2765738T3 (es) | 2020-06-10 |
AU2016348549A1 (en) | 2018-04-26 |
IL259004A (en) | 2018-06-28 |
CN108349979B (zh) | 2021-04-09 |
JP6872541B2 (ja) | 2021-05-19 |
HK1256751A1 (zh) | 2019-10-04 |
EA036851B1 (ru) | 2020-12-28 |
ZA201802842B (en) | 2021-04-28 |
CA3001768C (en) | 2022-12-13 |
PH12018500944A1 (en) | 2018-11-19 |
CO2018005163A2 (es) | 2018-06-20 |
CA3001768A1 (en) | 2017-05-11 |
US10947239B2 (en) | 2021-03-16 |
EP3371188A1 (en) | 2018-09-12 |
MX2018005342A (es) | 2018-08-15 |
SG11201803605YA (en) | 2018-05-30 |
WO2017076900A1 (en) | 2017-05-11 |
MY194700A (en) | 2022-12-15 |
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