MA50375A - Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2 - Google Patents
Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2Info
- Publication number
- MA50375A MA50375A MA050375A MA50375A MA50375A MA 50375 A MA50375 A MA 50375A MA 050375 A MA050375 A MA 050375A MA 50375 A MA50375 A MA 50375A MA 50375 A MA50375 A MA 50375A
- Authority
- MA
- Morocco
- Prior art keywords
- triazolo
- pyrimidine
- compositions containing
- compounds used
- pde2 inhibitors
- Prior art date
Links
- 229940121828 Phosphodiesterase 2 inhibitor Drugs 0.000 title 1
- -1 [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE-7-YL Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983387P | 2014-04-23 | 2014-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50375A true MA50375A (fr) | 2021-05-26 |
Family
ID=53055118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050375A MA50375A (fr) | 2014-04-23 | 2015-04-22 | Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9932345B2 (fr) |
| EP (2) | EP3597649B8 (fr) |
| JP (1) | JP6626449B2 (fr) |
| KR (1) | KR102471058B1 (fr) |
| CN (2) | CN106459062A (fr) |
| AU (2) | AU2015249753B2 (fr) |
| BR (1) | BR112016024713B1 (fr) |
| CA (1) | CA2938294C (fr) |
| DK (2) | DK3597649T3 (fr) |
| ES (2) | ES2759246T3 (fr) |
| HR (1) | HRP20212035T1 (fr) |
| HU (1) | HUE057317T2 (fr) |
| IL (2) | IL248292A (fr) |
| MA (1) | MA50375A (fr) |
| MX (1) | MX358004B (fr) |
| NZ (1) | NZ725161A (fr) |
| PL (1) | PL3597649T3 (fr) |
| PT (1) | PT3597649T (fr) |
| RU (1) | RU2659070C9 (fr) |
| SG (1) | SG11201606216UA (fr) |
| SI (1) | SI3597649T1 (fr) |
| TW (1) | TWI664181B (fr) |
| WO (1) | WO2015164508A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ725161A (en) | 2014-04-23 | 2017-10-27 | Dart Neuroscience (Cayman) Ltd | Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors |
| JP6563017B2 (ja) | 2014-08-28 | 2019-08-21 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| US10239882B2 (en) | 2014-11-05 | 2019-03-26 | Dart Neuroscience (Cayman) Ltd. | Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors |
| AU2016348549B2 (en) * | 2015-11-02 | 2020-07-23 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound |
| MX2018010191A (es) | 2016-02-25 | 2019-05-20 | Asceneuron S A | Inhibidores de glucosidasa. |
| KR20180132060A (ko) | 2016-02-25 | 2018-12-11 | 아셰뉴론 에스아 | 피페라진 유도체의 산 부가 염 |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| EP3419971B1 (fr) | 2016-02-25 | 2022-04-20 | Asceneuron SA | Inhibiteurs de glycosidases |
| CA3038913A1 (fr) * | 2016-11-02 | 2018-05-11 | Janssen Pharmaceutica Nv | Composes de [1,2,4] triazolo [1,5-a] pyrimidine en tant qu'inhibiteurs de pde2 |
| CN109923116B (zh) | 2016-11-02 | 2022-12-06 | 詹森药业有限公司 | 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶衍生物 |
| EA039102B1 (ru) * | 2016-11-02 | 2021-12-03 | Янссен Фармацевтика Нв | Соединения [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2 |
| WO2018109198A1 (fr) | 2016-12-16 | 2018-06-21 | Janssen Pharmaceutica Nv | Composés inhibiteurs d'oga bicyclique |
| JP2020509004A (ja) * | 2017-02-27 | 2020-03-26 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｏｇａ阻害剤としての、ピペリジン、モルホリンまたはピペラジンで置換されている［１，２，４］−トリアゾロ［１，５−ａ］−ピリミジニル誘導体 |
| EP3672959A1 (fr) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Inhibiteurs linéaires de la glycosidase |
| WO2020039028A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Inhibiteurs de tétrahydro-benzoazépine glycosidase |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| WO2020039029A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Composés spiro utilisés en tant qu'inhibiteurs de glycosidases |
| CA3138307A1 (fr) | 2019-05-13 | 2020-11-19 | Ecolab Usa Inc. | 1,2,4-triazolo[1,5-a] derive de la pyrimidine comme inhibiteur de corrosion du cuivre |
| TW202220992A (zh) | 2020-08-05 | 2022-06-01 | 匈牙利商羅特格登公司 | 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2510111A1 (fr) * | 1981-07-24 | 1983-01-28 | Roussel Uclaf | Nouveaux derives du piperidin-3-yl indole, leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5478825A (en) | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
| HU208693B (en) * | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
| US9931318B2 (en) | 2003-04-08 | 2018-04-03 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
| EP2305353A1 (fr) | 2000-08-10 | 2011-04-06 | Cold Spring Harbor Laboratory | Apprentissage cognitif amélioré |
| US7868015B2 (en) | 2000-08-10 | 2011-01-11 | Cold Spring Harbor Laboratory | Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit |
| DE10064105A1 (de) | 2000-12-21 | 2002-06-27 | Bayer Ag | Neue Substituierte Imidazotriazinone |
| WO2002064211A1 (fr) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Inhibiteurs de thrombine |
| DE10108752A1 (de) | 2001-02-23 | 2002-09-05 | Bayer Ag | Neue Substituierte Imidazotriazinone |
| FR2832711B1 (fr) * | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
| AU2003276220A1 (en) | 2002-11-13 | 2004-06-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 2a (pde2a) |
| US20070275961A1 (en) | 2003-06-04 | 2007-11-29 | Vernalis (Cambridge) Limited. | Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine |
| WO2005041957A1 (fr) | 2003-10-29 | 2005-05-12 | Pfizer Products Inc. | Derives d'oxindole et leur utilisation comme inhibiteurs de la phosphodiesterase de type 2 |
| DE10356579A1 (de) | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
| EP1548011A1 (fr) | 2003-12-23 | 2005-06-29 | Neuro3D | Dérivés de 1,4-benzodiazépine-2-one comme inhibiteurs de PDE2 phosphodiesterase, leurs préparation et utilisation thérapeutique |
| CA2578368C (fr) | 2004-09-02 | 2013-07-02 | Altana Pharma Ag | Triazolophtalazines |
| JP5130053B2 (ja) | 2005-01-05 | 2013-01-30 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリアゾロフタラジン |
| BRPI0606379A2 (pt) | 2005-01-05 | 2009-06-23 | Nycomed Gmbh | triazolftalazinas |
| US7868016B2 (en) | 2005-07-13 | 2011-01-11 | Baxter International Inc. | Pharmaceutical formulations of endo-N-(9-methyl-9-azabicyclo[3,3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride |
| CN101321758A (zh) * | 2005-10-03 | 2008-12-10 | 阿斯利康(瑞典)有限公司 | 用于治疗哮喘和慢性阻塞性肺病的新5,6－二氢吡唑并[3,4－e][1,4]二氮杂－4(1H)－酮衍生物 |
| KR100844125B1 (ko) * | 2007-03-23 | 2008-07-04 | 한국화학연구원 | 7-(3′,4′-디알콕시페닐)-[1,2,4]트리아졸로[1,5-ａ]피리미딘 화합물, 이의 제조방법 및 이를 포함하는 천식 및만성폐쇄성 폐질환을 포함한 염증관련 질환, 관절염,아토피 피부염, 암 및 뇌질환의 치료 및 예방을 위한약제학적 조성물 |
| CA2684879A1 (fr) | 2007-05-15 | 2008-11-27 | Helicon Therapeutics, Inc. | Methodes d'identification des genes participant a la formation de la memoire au moyen d'arn interferent court (arnic) |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| WO2010054260A1 (fr) | 2008-11-07 | 2010-05-14 | Biotie Therapies Gmbh | Dérivés d'imidazo[5,1-c][1,2,4]benzotriazine en tant qu'inhibiteurs de phosphodiestérases |
| WO2010054253A1 (fr) | 2008-11-07 | 2010-05-14 | Biotie Therapies Gmbh | Dérivés de triazine en tant qu’inhibiteurs de phosphodiestérases |
| GEP20146098B (en) | 2009-03-31 | 2014-05-27 | Boehringer Ingelheim Int | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their usage as pde9a modulators |
| US8680116B2 (en) | 2009-07-22 | 2014-03-25 | Merck Sharp & Dohme Corp. | Quinolinone PDE2 inhibitors |
| CA2818903C (fr) * | 2010-12-14 | 2021-03-23 | Electrophoretics Limited | 5-(1,3-benzoxazol-2-yl)-4-(pyridine-4-yl)pyrimidine-2-amine et son utilisation comme inhibiteur de caseine kinase 1 delta |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| PE20140236A1 (es) * | 2011-02-23 | 2014-03-14 | Pfizer | IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS |
| AU2012265970A1 (en) | 2011-06-07 | 2013-11-28 | Pfizer Inc. | Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors |
| AU2012277912B2 (en) | 2011-06-27 | 2017-03-23 | Janssen Pharmaceutica Nv | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives |
| WO2013034755A1 (fr) | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Dérivés de triazolopyrazine et leur utilisation pour le traitement de troubles neurologiques et psychiatriques |
| WO2013034758A1 (fr) | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Triazolopyrazines substituées et leurs utilisations |
| JP2014526453A (ja) | 2011-09-09 | 2014-10-06 | ハー・ルンドベック・アクチエゼルスカベット | ピリジン化合物およびそれらの使用 |
| US20130116241A1 (en) * | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| CN103183675A (zh) * | 2011-12-27 | 2013-07-03 | 山东轩竹医药科技有限公司 | 磷酸二酯酶-4抑制剂 |
| WO2015012328A1 (fr) * | 2013-07-24 | 2015-01-29 | 武田薬品工業株式会社 | Composé hétérocyclique |
| NZ725161A (en) | 2014-04-23 | 2017-10-27 | Dart Neuroscience (Cayman) Ltd | Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors |
| US10239882B2 (en) | 2014-11-05 | 2019-03-26 | Dart Neuroscience (Cayman) Ltd. | Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors |
-
2015
- 2015-04-22 NZ NZ725161A patent/NZ725161A/en unknown
- 2015-04-22 PT PT191949304T patent/PT3597649T/pt unknown
- 2015-04-22 DK DK19194930.4T patent/DK3597649T3/da active
- 2015-04-22 AU AU2015249753A patent/AU2015249753B2/en active Active
- 2015-04-22 EP EP19194930.4A patent/EP3597649B8/fr active Active
- 2015-04-22 MX MX2016013860A patent/MX358004B/es active IP Right Grant
- 2015-04-22 MA MA050375A patent/MA50375A/fr unknown
- 2015-04-22 BR BR112016024713-2A patent/BR112016024713B1/pt active IP Right Grant
- 2015-04-22 EP EP15721086.5A patent/EP3134413B1/fr active Active
- 2015-04-22 HR HRP20212035TT patent/HRP20212035T1/hr unknown
- 2015-04-22 KR KR1020167032113A patent/KR102471058B1/ko active IP Right Grant
- 2015-04-22 RU RU2016143387A patent/RU2659070C9/ru active
- 2015-04-22 ES ES15721086T patent/ES2759246T3/es active Active
- 2015-04-22 HU HUE19194930A patent/HUE057317T2/hu unknown
- 2015-04-22 ES ES19194930T patent/ES2902806T3/es active Active
- 2015-04-22 CN CN201580030165.6A patent/CN106459062A/zh active Pending
- 2015-04-22 CA CA2938294A patent/CA2938294C/fr active Active
- 2015-04-22 CN CN201910367854.6A patent/CN110092788B/zh active Active
- 2015-04-22 WO PCT/US2015/027102 patent/WO2015164508A1/fr active Application Filing
- 2015-04-22 SG SG11201606216UA patent/SG11201606216UA/en unknown
- 2015-04-22 SI SI201531770T patent/SI3597649T1/sl unknown
- 2015-04-22 JP JP2016549758A patent/JP6626449B2/ja active Active
- 2015-04-22 PL PL19194930T patent/PL3597649T3/pl unknown
- 2015-04-22 DK DK15721086.5T patent/DK3134413T3/da active
- 2015-04-22 US US15/306,069 patent/US9932345B2/en active Active
- 2015-04-23 TW TW104113093A patent/TWI664181B/zh active
-
2016
- 2016-10-10 IL IL248292A patent/IL248292A/en active IP Right Grant
-
2017
- 2017-08-30 IL IL254224A patent/IL254224B/en active IP Right Grant
-
2018
- 2018-02-26 US US15/905,672 patent/US10501465B2/en active Active
-
2019
- 2019-11-25 US US16/694,869 patent/US11186582B2/en active Active
- 2019-12-20 AU AU2019283994A patent/AU2019283994C1/en active Active
-
2022
- 2022-06-27 US US17/850,668 patent/US20230192698A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA50375A (fr) | Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2 | |
| CL2019000942A1 (es) | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret. | |
| MA53675A (fr) | Composés substitués de pyrazolo[1,5-a]pyridine en tant qu'inhibiteurs de la kinase ret | |
| MA52987A (fr) | Dérivés de pyrazolo[1,5-a]pyrazin-4-yl en tant qu'inhibiteurs de jak | |
| MA41551A (fr) | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 | |
| ZA201700737B (en) | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer | |
| DK3322706T3 (da) | Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer | |
| SI3107914T1 (sl) | Pirazolo(1,5-A)pirimidin-5,7-diaminske spojine kot inhibitorji CDK in njihova terapevtska uporaba | |
| MA43169A (fr) | Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma | |
| TW201613925A (en) | Imidazopyrazines as LSD1 inhibitors | |
| MA51229A (fr) | Hétérocycles bicycliques utilisés comme inhibiteurs des fgfr | |
| MA42919A (fr) | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx | |
| MA42918A (fr) | Composés bicycliques utilisés en tant qu'inhibiteurs d'atx | |
| IL266305B (en) | History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors | |
| EA201891251A1 (ru) | Бициклические ингибиторы pad4 | |
| MA46690A (fr) | Composés de [1,2,4]triazolo [1,5-a]pyrimidine en tant qu'inhibiteurs de pde2 | |
| EP3328840A4 (fr) | Composés bicycliques triazolo substitués en tant qu'inhibiteurs de pde2 | |
| EP3319966A4 (fr) | Composés hétérocycliques bicycliques utilisés comme inhibiteurs de pde2 | |
| MA52593A (fr) | 1h-pyrazolo[4,3-b]pyridines en tant qu'inhibiteurs pde1 | |
| ZA201605666B (en) | Pyrazolo[1,5-a]pyrimidines as antiviral compounds | |
| CL2016000496A1 (es) | Compuestos derivados de 1,2,4-triazolo[1,5-a]-piridina, inhibidores de una janus cinasa, tal como jak1; composiciones farmacológicas; útiles para el tratamiento de enfermedades inflamatorias. | |
| MX2017007377A (es) | Compuestos organicos. | |
| ZA201607736B (en) | Analogs of 4h-pyrazolo[1,5-a]benzimidazole compounds as parp inhibitors | |
| EA201690716A1 (ru) | ПИРИДО[2,3-d]ПИРИМИДИН-4-ОНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ТАНКИРАЗЫ | |
| EA202191301A1 (ru) | СОСТАВ ТАБЛЕТОК 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛМЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА |