DK3597649T3 - Sammensætninger indeholdende substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer - Google Patents
Sammensætninger indeholdende substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer Download PDFInfo
- Publication number
- DK3597649T3 DK3597649T3 DK19194930.4T DK19194930T DK3597649T3 DK 3597649 T3 DK3597649 T3 DK 3597649T3 DK 19194930 T DK19194930 T DK 19194930T DK 3597649 T3 DK3597649 T3 DK 3597649T3
- Authority
- DK
- Denmark
- Prior art keywords
- triazolo
- pyrimidin
- compounds
- compositions containing
- containing substituted
- Prior art date
Links
- 229940121828 Phosphodiesterase 2 inhibitor Drugs 0.000 title 1
- -1 [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983387P | 2014-04-23 | 2014-04-23 | |
| EP15721086.5A EP3134413B1 (en) | 2014-04-23 | 2015-04-22 | Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3597649T3 true DK3597649T3 (da) | 2022-01-10 |
Family
ID=53055118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15721086.5T DK3134413T3 (da) | 2014-04-23 | 2015-04-22 | Substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer |
| DK19194930.4T DK3597649T3 (da) | 2014-04-23 | 2015-04-22 | Sammensætninger indeholdende substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15721086.5T DK3134413T3 (da) | 2014-04-23 | 2015-04-22 | Substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9932345B2 (da) |
| EP (2) | EP3134413B1 (da) |
| JP (1) | JP6626449B2 (da) |
| KR (1) | KR102471058B1 (da) |
| CN (2) | CN106459062A (da) |
| AU (2) | AU2015249753B2 (da) |
| BR (1) | BR112016024713B1 (da) |
| CA (1) | CA2938294C (da) |
| DK (2) | DK3134413T3 (da) |
| ES (2) | ES2759246T3 (da) |
| HR (1) | HRP20212035T1 (da) |
| HU (1) | HUE057317T2 (da) |
| IL (2) | IL248292A (da) |
| MA (1) | MA50375A (da) |
| MX (1) | MX358004B (da) |
| NZ (1) | NZ725161A (da) |
| PL (1) | PL3597649T3 (da) |
| PT (1) | PT3597649T (da) |
| RU (1) | RU2659070C9 (da) |
| SG (1) | SG11201606216UA (da) |
| SI (1) | SI3597649T1 (da) |
| TW (1) | TWI664181B (da) |
| WO (1) | WO2015164508A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA50375A (fr) | 2014-04-23 | 2021-05-26 | Dart Neuroscience Cayman Ltd | Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2 |
| MA53944A (fr) | 2014-08-28 | 2021-08-25 | Asceneuron Sa | Inhibiteurs de la glycosidase |
| TWI568737B (zh) | 2014-11-05 | 2017-02-01 | 達特神經科學（開曼）有限責任公司 | 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物 |
| BR112018008431A2 (pt) * | 2015-11-02 | 2018-11-06 | Janssen Pharmaceutica Nv | composto de [1,2,4]triazolo[1,5-a]pirimidin-7-il |
| EP3419971B1 (en) | 2016-02-25 | 2022-04-20 | Asceneuron SA | Glycosidase inhibitors |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| MA43680A (fr) | 2016-02-25 | 2018-11-28 | Asceneuron Sa | Inhibiteurs de glycosidases |
| AU2017222962B2 (en) | 2016-02-25 | 2021-03-25 | Asceneuron S. A. | Acid addition salts of piperazine derivatives |
| SG11201903892UA (en) * | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
| ES2855032T3 (es) | 2016-11-02 | 2021-09-23 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
| AU2017353313C1 (en) * | 2016-11-02 | 2022-06-09 | Janssen Pharmaceutica Nv | (1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors |
| EP3555094A1 (en) * | 2016-12-16 | 2019-10-23 | Janssen Pharmaceutica NV | Bicyclic oga inhibitor compounds |
| WO2018154133A1 (en) | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors |
| EP3672959A1 (en) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Linear glycosidase inhibitors |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| US11814734B2 (en) | 2019-05-13 | 2023-11-14 | Ecolab Usa Inc. | 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor |
| TW202220992A (zh) | 2020-08-05 | 2022-06-01 | 匈牙利商羅特格登公司 | 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物 |
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| FR2510111A1 (fr) * | 1981-07-24 | 1983-01-28 | Roussel Uclaf | Nouveaux derives du piperidin-3-yl indole, leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5478825A (en) | 1991-02-22 | 1995-12-26 | Egis Gyogyszergyar | 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives |
| HU208693B (en) | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them |
| US7868015B2 (en) | 2000-08-10 | 2011-01-11 | Cold Spring Harbor Laboratory | Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit |
| US9931318B2 (en) | 2003-04-08 | 2018-04-03 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
| WO2002013867A2 (en) | 2000-08-10 | 2002-02-21 | Cold Spring Harbor Laboratory | Augmented cognitive training |
| DE10064105A1 (de) | 2000-12-21 | 2002-06-27 | Bayer Ag | Neue Substituierte Imidazotriazinone |
| WO2002064211A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
| DE10108752A1 (de) | 2001-02-23 | 2002-09-05 | Bayer Ag | Neue Substituierte Imidazotriazinone |
| FR2832711B1 (fr) * | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
| AU2003276220A1 (en) | 2002-11-13 | 2004-06-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human phosphodiesterase 2a (pde2a) |
| EP1644003A1 (en) | 2003-06-04 | 2006-04-12 | Vernalis (Cambridge) Limited | Triazolo ´1,5-a!pyrimidines and their use in medicine |
| WO2005041957A1 (en) | 2003-10-29 | 2005-05-12 | Pfizer Products Inc. | Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors |
| DE10356579A1 (de) | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
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| NZ594567A (en) | 2009-03-31 | 2013-12-20 | Boehringer Ingelheim Int | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
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| CN103183675A (zh) * | 2011-12-27 | 2013-07-03 | 山东轩竹医药科技有限公司 | 磷酸二酯酶-4抑制剂 |
| US20160159808A1 (en) | 2013-07-24 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| MA50375A (fr) | 2014-04-23 | 2021-05-26 | Dart Neuroscience Cayman Ltd | Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2 |
| TWI568737B (zh) | 2014-11-05 | 2017-02-01 | 達特神經科學（開曼）有限責任公司 | 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物 |
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2015
- 2015-04-22 MA MA050375A patent/MA50375A/fr unknown
- 2015-04-22 BR BR112016024713-2A patent/BR112016024713B1/pt active IP Right Grant
- 2015-04-22 AU AU2015249753A patent/AU2015249753B2/en active Active
- 2015-04-22 CN CN201580030165.6A patent/CN106459062A/zh active Pending
- 2015-04-22 RU RU2016143387A patent/RU2659070C9/ru active
- 2015-04-22 CN CN201910367854.6A patent/CN110092788B/zh active Active
- 2015-04-22 HU HUE19194930A patent/HUE057317T2/hu unknown
- 2015-04-22 MX MX2016013860A patent/MX358004B/es active IP Right Grant
- 2015-04-22 ES ES15721086T patent/ES2759246T3/es active Active
- 2015-04-22 DK DK15721086.5T patent/DK3134413T3/da active
- 2015-04-22 US US15/306,069 patent/US9932345B2/en active Active
- 2015-04-22 PL PL19194930T patent/PL3597649T3/pl unknown
- 2015-04-22 PT PT191949304T patent/PT3597649T/pt unknown
- 2015-04-22 EP EP15721086.5A patent/EP3134413B1/en active Active
- 2015-04-22 JP JP2016549758A patent/JP6626449B2/ja active Active
- 2015-04-22 SG SG11201606216UA patent/SG11201606216UA/en unknown
- 2015-04-22 SI SI201531770T patent/SI3597649T1/sl unknown
- 2015-04-22 HR HRP20212035TT patent/HRP20212035T1/hr unknown
- 2015-04-22 CA CA2938294A patent/CA2938294C/en active Active
- 2015-04-22 KR KR1020167032113A patent/KR102471058B1/ko active IP Right Grant
- 2015-04-22 WO PCT/US2015/027102 patent/WO2015164508A1/en active Application Filing
- 2015-04-22 ES ES19194930T patent/ES2902806T3/es active Active
- 2015-04-22 DK DK19194930.4T patent/DK3597649T3/da active
- 2015-04-22 EP EP19194930.4A patent/EP3597649B8/en active Active
- 2015-04-22 NZ NZ725161A patent/NZ725161A/en unknown
- 2015-04-23 TW TW104113093A patent/TWI664181B/zh active
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2016
- 2016-10-10 IL IL248292A patent/IL248292A/en active IP Right Grant
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2017
- 2017-08-30 IL IL254224A patent/IL254224B/en active IP Right Grant
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2018
- 2018-02-26 US US15/905,672 patent/US10501465B2/en active Active
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2019
- 2019-11-25 US US16/694,869 patent/US11186582B2/en active Active
- 2019-12-20 AU AU2019283994A patent/AU2019283994C1/en active Active
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2022
- 2022-06-27 US US17/850,668 patent/US20230192698A1/en active Pending
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