MX366840B - Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde. - Google Patents
Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde.Info
- Publication number
- MX366840B MX366840B MX2017000522A MX2017000522A MX366840B MX 366840 B MX366840 B MX 366840B MX 2017000522 A MX2017000522 A MX 2017000522A MX 2017000522 A MX2017000522 A MX 2017000522A MX 366840 B MX366840 B MX 366840B
- Authority
- MX
- Mexico
- Prior art keywords
- novel
- substituted pyrimidines
- pde inhibitors
- medicaments
- indices
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
La invención se relaciona con compuestos novedosos de pirimidina condensada de la fórmula general (I) en los cuales los agrupamientos químicos, sustituyentes e índices son como se define en la descripción, y con su uso como medicamentos, en particular como medicamentos para el tratamiento de condiciones y enfermedades que se puedan tratar mediante la inhibición de la enzima de PDE4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14002451 | 2014-07-16 | ||
PCT/EP2015/001475 WO2016008592A1 (en) | 2014-07-16 | 2015-07-16 | Novel 2,5-substituted pyrimidines as pde inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2017000522A MX2017000522A (es) | 2017-05-01 |
MX366840B true MX366840B (es) | 2019-07-26 |
Family
ID=51210960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017000522A MX366840B (es) | 2014-07-16 | 2015-07-16 | Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde. |
Country Status (19)
Country | Link |
---|---|
US (1) | US9315490B2 (es) |
EP (2) | EP3415509A1 (es) |
JP (1) | JP6726655B2 (es) |
KR (1) | KR20170032420A (es) |
CN (1) | CN106488916A (es) |
AR (1) | AR101197A1 (es) |
AU (1) | AU2015291477B2 (es) |
BR (1) | BR112017000826A2 (es) |
CA (1) | CA2955062A1 (es) |
CL (1) | CL2017000105A1 (es) |
CO (1) | CO2017001523A2 (es) |
EA (1) | EA201790209A1 (es) |
EC (1) | ECSP17010482A (es) |
IL (1) | IL250025A0 (es) |
MX (1) | MX366840B (es) |
PE (1) | PE20170119A1 (es) |
TW (1) | TW201609708A (es) |
WO (1) | WO2016008592A1 (es) |
ZA (1) | ZA201701132B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR101198A1 (es) * | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Pirimidinas 2,5-sustituidas como inhibidores de pde4b |
AR101196A1 (es) * | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Compuestos de pirimidina sustituidos |
WO2017144633A1 (en) * | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Glycosidase inhibitors |
CN108570052A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用 |
WO2018234354A1 (en) | 2017-06-20 | 2018-12-27 | Grünenthal GmbH | NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS |
WO2018234353A1 (en) | 2017-06-20 | 2018-12-27 | Grünenthal GmbH | NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE |
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KR100331255B1 (ko) | 1993-07-02 | 2002-10-25 | 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 | 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도 |
AU7683500A (en) * | 1999-10-12 | 2001-04-23 | Takeda Chemical Industries Ltd. | Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof |
JP2001233875A (ja) * | 1999-10-12 | 2001-08-28 | Takeda Chem Ind Ltd | ピリミジン−5−カルボキサミド化合物、その製造法およびその用途 |
US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
DE10163991A1 (de) * | 2001-12-24 | 2003-07-03 | Merck Patent Gmbh | Pyrrolo-pyrimidine |
RU2008117151A (ru) * | 2005-09-30 | 2009-11-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Деазапурины, пригодные в качестве ингибиторов янус-киназ |
TW201512189A (zh) | 2013-04-16 | 2015-04-01 | Gruenenthal Chemie | 新型被取代之嘧啶縮合化合物 |
AR101196A1 (es) * | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Compuestos de pirimidina sustituidos |
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EA201790209A1 (ru) | 2017-07-31 |
JP2017520600A (ja) | 2017-07-27 |
PE20170119A1 (es) | 2017-03-30 |
US20160024053A1 (en) | 2016-01-28 |
JP6726655B2 (ja) | 2020-07-22 |
AU2015291477B2 (en) | 2019-02-21 |
ECSP17010482A (es) | 2017-05-31 |
MX2017000522A (es) | 2017-05-01 |
AR101197A1 (es) | 2016-11-30 |
ZA201701132B (en) | 2019-07-31 |
CA2955062A1 (en) | 2016-01-21 |
TW201609708A (zh) | 2016-03-16 |
BR112017000826A2 (pt) | 2017-12-05 |
CN106488916A (zh) | 2017-03-08 |
CL2017000105A1 (es) | 2017-07-21 |
EP3169680A1 (en) | 2017-05-24 |
US9315490B2 (en) | 2016-04-19 |
CO2017001523A2 (es) | 2017-05-10 |
KR20170032420A (ko) | 2017-03-22 |
EP3415509A1 (en) | 2018-12-19 |
IL250025A0 (en) | 2017-03-30 |
AU2015291477A1 (en) | 2017-03-09 |
WO2016008592A1 (en) | 2016-01-21 |
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