PE20170119A1 - Novedosas pirimidinas 2,5-sustituidas - Google Patents

Novedosas pirimidinas 2,5-sustituidas

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Publication number
PE20170119A1
PE20170119A1 PE2017000067A PE2017000067A PE20170119A1 PE 20170119 A1 PE20170119 A1 PE 20170119A1 PE 2017000067 A PE2017000067 A PE 2017000067A PE 2017000067 A PE2017000067 A PE 2017000067A PE 20170119 A1 PE20170119 A1 PE 20170119A1
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PE
Peru
Prior art keywords
alkyl
new
substituted pyrimidines
optionally substituted
substituted
Prior art date
Application number
PE2017000067A
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English (en)
Inventor
Antonio Nardi
Florian Jakob
Ingo Konetzki
Tobias Craan
Christian Hesslinger
Andre Welbers
Original Assignee
Gruenenthal Chemie
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Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20170119A1 publication Critical patent/PE20170119A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

La presente invencion se refiere a pirimidinas 2,5-sustituidas de formula (I), donde: A, B, C son N o CH; R1 es (C1-C6)-alquilo, (C1-C6)-hidroxialquilo, entre otros; G es fenilo o heteroarilo de 5 o 6 miembros opcionalmente sustituido; R4 es H, (C1-C6)-alquilo, entre otros; R2 y R3 son H o (C1-C6)- alquilo, (C1-C6)-haloalquilo, entre otros o R2 y R3 junto a N forman un residuo heteroalifatico monociclico o biciclico de entre 3 y 12 miembros opcionalmente sustituido. Tambien se refiere a un medicamento. Dichos compuestos inhiben la enzima fosfodiesterasa 4 (PDE4), siendo utiles en el tratamiento de enfermedades inflamatorias de las articulaciones, piel, ojos, enfermedades gastrointestinales, entre otras
PE2017000067A 2014-07-16 2015-07-16 Novedosas pirimidinas 2,5-sustituidas PE20170119A1 (es)

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EP14002451 2014-07-16

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PE20170119A1 true PE20170119A1 (es) 2017-03-30

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US (1) US9315490B2 (es)
EP (2) EP3169680A1 (es)
JP (1) JP6726655B2 (es)
KR (1) KR20170032420A (es)
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AU2017222958B2 (en) * 2016-02-25 2019-07-18 Asceneuron S. A. Glycosidase inhibitors
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