PE20181287A1 - Ciano tienotriazolpirazinas y usos de las mismas - Google Patents

Ciano tienotriazolpirazinas y usos de las mismas

Info

Publication number
PE20181287A1
PE20181287A1 PE2018000366A PE2018000366A PE20181287A1 PE 20181287 A1 PE20181287 A1 PE 20181287A1 PE 2018000366 A PE2018000366 A PE 2018000366A PE 2018000366 A PE2018000366 A PE 2018000366A PE 20181287 A1 PE20181287 A1 PE 20181287A1
Authority
PE
Peru
Prior art keywords
halogen
alkyl
anothriazolpirazines
cyane
same
Prior art date
Application number
PE2018000366A
Other languages
English (en)
Inventor
James E Bradner
Jun Qin
Minoru Tanaka
Dennis Buckley
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of PE20181287A1 publication Critical patent/PE20181287A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Se refiere a compuestos ciano tienotriazolpirazinas de formulas I y II, donde RA1 es H, halogeno, entre otros; RA2 es H, halogeno, entre otros; X1 es N o CR5; R5 es H, halogeno, entre otros; RB es H, halogeno, entre otros; R1 es H, halogeno, alquilo, entre otros; R2 es H, halogeno, alquilo, entre otros; RC es halogeno, alquenilo, entre otros; el anillo C es arilo o heteroarilo; RM es -CN, -N(RF)2; RF es H, alquilo opcionalmente sustitutido, entre otros; c es 0, 1, 2, 3 o 4. Tambien se refiere a composiciones farmaceuticas. Dichos compuestos son moleculas de union a bromodominios y/o proteinas que contienen bromodominio y son utiles para el tratamiento de enfermedades proliferativas, cardiovasculares, entre otras
PE2018000366A 2015-09-11 2016-09-09 Ciano tienotriazolpirazinas y usos de las mismas PE20181287A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562217521P 2015-09-11 2015-09-11

Publications (1)

Publication Number Publication Date
PE20181287A1 true PE20181287A1 (es) 2018-08-07

Family

ID=58240288

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000366A PE20181287A1 (es) 2015-09-11 2016-09-09 Ciano tienotriazolpirazinas y usos de las mismas

Country Status (20)

Country Link
US (1) US11306105B2 (es)
EP (1) EP3347021A4 (es)
JP (1) JP2018526421A (es)
KR (1) KR20180049058A (es)
CN (1) CN108472300A (es)
AU (1) AU2016319116B2 (es)
BR (1) BR112018004618A2 (es)
CA (1) CA2996974A1 (es)
CL (2) CL2018000621A1 (es)
CO (1) CO2018002483A2 (es)
CR (1) CR20180200A (es)
HK (1) HK1256417A1 (es)
IL (1) IL257594A (es)
MX (1) MX2018003031A (es)
PE (1) PE20181287A1 (es)
PH (1) PH12018550027A1 (es)
RU (1) RU2750164C2 (es)
SG (1) SG10202007090UA (es)
WO (1) WO2017044849A1 (es)
ZA (1) ZA201801548B (es)

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US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
PE20181086A1 (es) * 2015-09-11 2018-07-05 Dana Farber Cancer Inst Inc Acetamida tienotrizolodiazepinas y usos de las mismas
BR112018004618A2 (pt) 2015-09-11 2018-09-25 Dana-Farber Cancer Institute, Inc. ciano tienotriazoldiazepinas e usos das mesmas
BR112018009798A8 (pt) 2015-11-25 2019-02-26 Dana Farber Cancer Inst Inc inibidores de bromodomínio bivalentes e usos dos mesmos
JP7417519B2 (ja) 2017-09-22 2024-01-18 石薬集団中奇制薬技術（石家庄）有限公司 チエノジアゼピン誘導体とその応用
CN108084193A (zh) * 2017-12-19 2018-05-29 郭守东 一种brd4蛋白抑制剂
EP3849987B1 (en) * 2018-09-11 2024-04-17 F. Hoffmann-La Roche AG Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
WO2022221786A2 (en) * 2022-06-22 2022-10-20 Plexium, Inc. Compounds and pharmaceutical compositions that modulate brd4

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