EA201790282A1 - Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофил-эластазы - Google Patents

Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофил-эластазы

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Publication number
EA201790282A1
EA201790282A1 EA201790282A EA201790282A EA201790282A1 EA 201790282 A1 EA201790282 A1 EA 201790282A1 EA 201790282 A EA201790282 A EA 201790282A EA 201790282 A EA201790282 A EA 201790282A EA 201790282 A1 EA201790282 A1 EA 201790282A1
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EA
Eurasian Patent Office
Prior art keywords
substituted bicyclic
elastasy
neutrofil
application
activity inhibitors
Prior art date
Application number
EA201790282A
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English (en)
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EA033263B1 (ru
Inventor
Торстен Ост
Ральф Андерскевитц
Кристиан Гнамм
Хольгер Хёш
Герд Моршхойзер
Штефан Петерс
Уве Йёрг Рис
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA201790282A1 publication Critical patent/EA201790282A1/ru
Publication of EA033263B1 publication Critical patent/EA033263B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Настоящее изобретение относится к замещенным бициклическим дигидропиримидинонам формулы 1и их применению в качестве ингибиторов активности нейтрофил-эластазы, фармацевтическим композициям, которые их содержат, и способам их применения в качестве средств для лечения и/или предотвращения легочных, желудочно-кишечных и мочеполовых заболеваний, воспалительных заболеваний кожи и глаз и других аутоиммунных и аллергических нарушений, отторжения аллотрансплантата, и онкологических заболеваний.
EA201790282A 2014-07-31 2015-07-30 Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофил-эластазы EA033263B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179288 2014-07-31
PCT/EP2015/067501 WO2016016365A1 (en) 2014-07-31 2015-07-30 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

Publications (2)

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EA201790282A1 true EA201790282A1 (ru) 2017-07-31
EA033263B1 EA033263B1 (ru) 2019-09-30

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US (1) US9475779B2 (ru)
EP (2) EP3539952B1 (ru)
JP (1) JP6345337B2 (ru)
KR (1) KR102420210B1 (ru)
CN (2) CN107253933B (ru)
AP (1) AP2016009632A0 (ru)
AU (1) AU2015295283B2 (ru)
CA (1) CA2956745C (ru)
CL (1) CL2017000117A1 (ru)
CO (1) CO2017000745A2 (ru)
CY (1) CY1121933T1 (ru)
DK (1) DK3174861T3 (ru)
EA (1) EA033263B1 (ru)
ES (1) ES2740428T3 (ru)
HR (1) HRP20191353T1 (ru)
HU (1) HUE045530T2 (ru)
IL (1) IL249687B (ru)
LT (1) LT3174861T (ru)
ME (1) ME03526B (ru)
MX (1) MX2017001347A (ru)
MY (1) MY182438A (ru)
NZ (1) NZ727554A (ru)
PE (1) PE20170524A1 (ru)
PH (1) PH12017500114A1 (ru)
PL (1) PL3174861T3 (ru)
PT (1) PT3174861T (ru)
RS (1) RS59040B1 (ru)
SA (1) SA517380781B1 (ru)
SG (1) SG11201700658UA (ru)
SI (1) SI3174861T1 (ru)
UA (1) UA118130C2 (ru)
WO (1) WO2016016365A1 (ru)

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AU2015295283B2 (en) 2019-12-19
JP6345337B2 (ja) 2018-06-20
MY182438A (en) 2021-01-25
CL2017000117A1 (es) 2017-09-15
CN106660988B (zh) 2019-06-21
WO2016016365A1 (en) 2016-02-04
EP3539952B1 (en) 2022-06-22
EP3174861A1 (en) 2017-06-07
NZ727554A (en) 2022-09-30
IL249687A0 (en) 2017-02-28
PH12017500114A1 (en) 2017-05-29
SG11201700658UA (en) 2017-02-27
KR20170032465A (ko) 2017-03-22
HRP20191353T1 (hr) 2019-11-01
LT3174861T (lt) 2019-07-10
SI3174861T1 (sl) 2019-08-30
ME03526B (me) 2020-04-20
UA118130C2 (uk) 2018-11-26
AP2016009632A0 (en) 2016-12-31
KR102420210B1 (ko) 2022-07-13
JP2017525687A (ja) 2017-09-07
CN106660988A (zh) 2017-05-10
CN107253933B (zh) 2021-10-26
CO2017000745A2 (es) 2017-04-10
EP3174861B1 (en) 2019-05-15
RS59040B1 (sr) 2019-08-30
DK3174861T3 (da) 2019-08-12
SA517380781B1 (ar) 2020-09-21
EA033263B1 (ru) 2019-09-30
PE20170524A1 (es) 2017-05-19
IL249687B (en) 2019-11-28
EP3539952A1 (en) 2019-09-18
PT3174861T (pt) 2019-09-04
US9475779B2 (en) 2016-10-25
HUE045530T2 (hu) 2020-01-28
US20160031829A1 (en) 2016-02-04
AU2015295283A1 (en) 2017-01-12
CA2956745A1 (en) 2016-02-04
CA2956745C (en) 2023-03-14
CY1121933T1 (el) 2020-10-14
MX2017001347A (es) 2017-04-27
PL3174861T3 (pl) 2019-11-29
CN107253933A (zh) 2017-10-17
ES2740428T3 (es) 2020-02-05
BR112017001554A2 (pt) 2017-11-21

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