EA201500816A1 - Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофильной эластазы - Google Patents

Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофильной эластазы

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Publication number
EA201500816A1
EA201500816A1 EA201500816A EA201500816A EA201500816A1 EA 201500816 A1 EA201500816 A1 EA 201500816A1 EA 201500816 A EA201500816 A EA 201500816A EA 201500816 A EA201500816 A EA 201500816A EA 201500816 A1 EA201500816 A1 EA 201500816A1
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EA
Eurasian Patent Office
Prior art keywords
substituted bicyclic
elastasy
neutrofil
application
activity inhibitors
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EA201500816A
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English (en)
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EA030569B1 (ru
Inventor
Кристиан Гнамм
Торстен Ост
Штефан Петерс
Хольгер Хёш
Уве Йёрг Рис
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Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA201500816A1 publication Critical patent/EA201500816A1/ru
Publication of EA030569B1 publication Critical patent/EA030569B1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данное изобретение относится к замещенным бициклическим дигидропиримидинонам формулы 1и к их применению в качестве ингибиторов активности нейтрофильной эластазы, к фармацевтическим композициям, которые их содержат, и способам их использования в качестве средств лечения и/или предотвращения лёгочных, желудочно-кишечных и мочеполовых заболеваний, воспалительных заболеваний кожи и глаз и других аутоиммунных и аллергических расстройств, отторжения аллотрансплантата и онкологических заболеваний.
EA201500816A 2013-02-06 2014-02-05 Замещенные бициклические дигидропиримидиноны и их применение в качестве ингибиторов активности нейтрофильной эластазы EA030569B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13154256 2013-02-06
PCT/EP2014/052217 WO2014122160A1 (en) 2013-02-06 2014-02-05 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

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EA201500816A1 true EA201500816A1 (ru) 2016-01-29
EA030569B1 EA030569B1 (ru) 2018-08-31

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US (4) US20140221335A1 (ru)
EP (1) EP2953943B1 (ru)
JP (1) JP6130519B2 (ru)
KR (1) KR102221201B1 (ru)
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AP (1) AP2015008535A0 (ru)
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