EA201790795A1 - СОЕДИНЕНИЯ 4Н-ПИРИДО[1,2-a]ПИРИМИДИН-4-ОНА - Google Patents
СОЕДИНЕНИЯ 4Н-ПИРИДО[1,2-a]ПИРИМИДИН-4-ОНАInfo
- Publication number
- EA201790795A1 EA201790795A1 EA201790795A EA201790795A EA201790795A1 EA 201790795 A1 EA201790795 A1 EA 201790795A1 EA 201790795 A EA201790795 A EA 201790795A EA 201790795 A EA201790795 A EA 201790795A EA 201790795 A1 EA201790795 A1 EA 201790795A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- pyrido
- pyrimidin
- compositions
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/06—Zinc compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы I или II, способам их получения и их применению в качестве фармацевтических агентов или композиций для лечения неврологических расстройств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2014904868A AU2014904868A0 (en) | 2014-12-02 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | |
PCT/AU2015/000730 WO2016086261A1 (en) | 2014-12-02 | 2015-12-02 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201790795A1 true EA201790795A1 (ru) | 2017-07-31 |
EA031505B1 EA031505B1 (ru) | 2019-01-31 |
Family
ID=56090727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790795A EA031505B1 (ru) | 2014-12-02 | 2015-12-02 | СОЕДИНЕНИЯ 4Н-ПИРИДО[1,2-а]ПИРИМИДИН-4-ОНА |
Country Status (10)
Country | Link |
---|---|
US (4) | US10287285B2 (ru) |
EP (1) | EP3227292B1 (ru) |
JP (2) | JP6784942B2 (ru) |
KR (1) | KR20170088851A (ru) |
CN (2) | CN107001360B (ru) |
AU (2) | AU2015358284B2 (ru) |
BR (1) | BR112017011335A2 (ru) |
CA (1) | CA2968090A1 (ru) |
EA (1) | EA031505B1 (ru) |
WO (1) | WO2016086261A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017040879A1 (en) * | 2015-09-04 | 2017-03-09 | Lysosomal Therapeutics Inc. | Thiazolo(3,2-a) pyrimidinone and other heterobicyclic pyrimidinone compounds for use in medical therapy |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022897A (en) * | 1974-03-04 | 1977-05-10 | E. R. Squibb & Sons, Inc. | CNS active compounds |
US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
HU178910B (en) * | 1977-08-19 | 1982-07-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
AU2002951868A0 (en) * | 2002-10-04 | 2002-10-24 | Prana Biotechnology Limited | Compound i |
NZ539211A (en) * | 2002-10-04 | 2008-05-30 | Prana Biotechnology Ltd | Neurologically-active compounds |
AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
CA2683756A1 (en) * | 2006-04-14 | 2007-10-25 | Prana Biotechnology Limited | Method of treatment of age-related macular degeneration(amd) |
US8163760B2 (en) * | 2006-06-22 | 2012-04-24 | Prana Biotechnology Limited | Use of pyridopyrimidine compounds in the treatment of gliomas |
US8785452B2 (en) * | 2008-06-17 | 2014-07-22 | Institut National De La Sante Et De La Recherche Medicale | Anti-infective compounds |
EP2157433A1 (en) | 2008-08-18 | 2010-02-24 | Centre National De La Recherche Scientifique (Cnrs) | New method for identifying compounds useful for treating and/or preventing diseases associated with bone loss |
WO2010136778A1 (en) * | 2009-05-29 | 2010-12-02 | Kudos Pharmaceuticals Limited | Dibenzothiophene derivatives as dna- pk inhibitors |
CN102812023A (zh) * | 2010-01-13 | 2012-12-05 | 韩国巴斯德研究所 | 抗感染吡啶并(1,2-a)嘧啶类 |
-
2015
- 2015-12-02 BR BR112017011335-0A patent/BR112017011335A2/pt not_active Application Discontinuation
- 2015-12-02 EP EP15865227.1A patent/EP3227292B1/en active Active
- 2015-12-02 EA EA201790795A patent/EA031505B1/ru unknown
- 2015-12-02 CA CA2968090A patent/CA2968090A1/en not_active Abandoned
- 2015-12-02 JP JP2017529392A patent/JP6784942B2/ja active Active
- 2015-12-02 WO PCT/AU2015/000730 patent/WO2016086261A1/en active Application Filing
- 2015-12-02 CN CN201580063673.4A patent/CN107001360B/zh not_active Expired - Fee Related
- 2015-12-02 US US15/529,891 patent/US10287285B2/en not_active Expired - Fee Related
- 2015-12-02 AU AU2015358284A patent/AU2015358284B2/en not_active Ceased
- 2015-12-02 KR KR1020177013830A patent/KR20170088851A/ko not_active Application Discontinuation
- 2015-12-02 CN CN202010904358.2A patent/CN111961050A/zh active Pending
-
2019
- 2019-05-10 US US16/409,296 patent/US10738050B2/en active Active
-
2020
- 2020-06-24 US US16/910,896 patent/US11008319B2/en active Active
- 2020-09-25 AU AU2020239797A patent/AU2020239797A1/en not_active Abandoned
- 2020-10-07 JP JP2020169555A patent/JP2021011492A/ja not_active Ceased
-
2021
- 2021-04-07 US US17/224,512 patent/US20210230159A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170267676A1 (en) | 2017-09-21 |
CN107001360A (zh) | 2017-08-01 |
AU2015358284A1 (en) | 2017-06-15 |
WO2016086261A1 (en) | 2016-06-09 |
US20190352301A1 (en) | 2019-11-21 |
JP2017537108A (ja) | 2017-12-14 |
KR20170088851A (ko) | 2017-08-02 |
US10287285B2 (en) | 2019-05-14 |
CN111961050A (zh) | 2020-11-20 |
AU2020239797A1 (en) | 2020-10-29 |
CN107001360B (zh) | 2020-09-18 |
JP2021011492A (ja) | 2021-02-04 |
AU2015358284B2 (en) | 2020-07-02 |
US10738050B2 (en) | 2020-08-11 |
US20200317670A1 (en) | 2020-10-08 |
EP3227292B1 (en) | 2022-03-09 |
JP6784942B2 (ja) | 2020-11-18 |
EP3227292A1 (en) | 2017-10-11 |
BR112017011335A2 (pt) | 2018-02-20 |
EA031505B1 (ru) | 2019-01-31 |
US20210230159A1 (en) | 2021-07-29 |
CA2968090A1 (en) | 2016-06-09 |
US11008319B2 (en) | 2021-05-18 |
EP3227292A4 (en) | 2018-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201990657A1 (ru) | Соединения и композиции в качестве ингибиторов эндосомальных toll-подобных рецепторов | |
EA201692301A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
PH12016501898A1 (en) | Quinoxaline derivatives useful as fgfr kinase modulators | |
EA201692177A1 (ru) | Соединения и композиции в качестве агонистов toll-подобного рецептора 7 | |
PH12016501570A1 (en) | Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor agonists | |
EA201792047A1 (ru) | Новые соединения | |
MX2018000396A (es) | Compuestos aza sustituidos como inhibidores de cinasa 4 asociada al receptor de interleucina 1 (irak-4). | |
NZ724878A (en) | Compounds and compositions as toll-like receptor 7 agonists | |
EA201790273A1 (ru) | Флагеллиновые композиции и их применение | |
MY192717A (en) | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof | |
EA201990240A1 (ru) | Новые трициклические соединения в качестве противораковых средств | |
UY36056A (es) | “compuestos de heteroarilo o arilo bicíclicos fusionados “. | |
TR201901886T4 (tr) | DNA-PK inhibitörleri. | |
PH12017500401A1 (en) | Therapeutic compounds as inhibitors of the orexin-1 receptor | |
EA201500383A1 (ru) | Производные 1,2,4-триазина для лечения вирусных инфекций | |
EA201890449A1 (ru) | Фумагиллиновые гетероциклические соединения и способы их получения и применения | |
EA201790949A1 (ru) | Замещенные 2,4-диаминохинолины в качестве новых противораковых средств | |
EA201691674A1 (ru) | 1,2-замещенные циклопентаны в качестве антагонистов рецептора орексина | |
EA201990400A1 (ru) | Соединения и композиции и их применение | |
EA201491520A1 (ru) | НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ C-met ПРОТЕИНКИНАЗ | |
EA201690783A1 (ru) | Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний | |
EA201891710A1 (ru) | Терапевтические соединения | |
WO2014035846A3 (en) | Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use | |
MY180844A (en) | Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions | |
EA201791432A1 (ru) | Композиции на основе пролекарства монометилфумарата |