EA201990678A1 - Гетероарилкарбоксамидные соединения в качестве ингибиторов ripk2 - Google Patents

Гетероарилкарбоксамидные соединения в качестве ингибиторов ripk2

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Publication number
EA201990678A1
EA201990678A1 EA201990678A EA201990678A EA201990678A1 EA 201990678 A1 EA201990678 A1 EA 201990678A1 EA 201990678 A EA201990678 A EA 201990678A EA 201990678 A EA201990678 A EA 201990678A EA 201990678 A1 EA201990678 A1 EA 201990678A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
methods
heteroarylcarboxamide
ripk2 inhibitors
relates
Prior art date
Application number
EA201990678A
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English (en)
Other versions
EA038128B1 (ru
Inventor
Пинжун Лю
Крейг Эндрю Миллер
Маолинь Юй
Чжунхуа Чжан
Забине Руппель
Анил К. Падьяна
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA201990678A1 publication Critical patent/EA201990678A1/ru
Publication of EA038128B1 publication Critical patent/EA038128B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Настоящее изобретение относится к соединениям формулы (I)или их фармацевтически приемлемым солям, где R, R, X, Y и Het имеют значения, указанные в данной заявке. Также изобретение относится к фармацевтическим композициям, которые содержат эти соединения, способам использования этих соединений для лечения различных заболеваний и расстройств, к способам получения этих соединений и промежуточных соединений, используемых в этих способах.
EA201990678A 2016-09-15 2017-09-06 Гетероарилкарбоксамидные соединения в качестве ингибиторов ripk2 EA038128B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662394779P 2016-09-15 2016-09-15
PCT/US2017/050197 WO2018052772A1 (en) 2016-09-15 2017-09-06 Heteroaryl carboxamide compounds as inhibitors of ripk2

Publications (2)

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EA201990678A1 true EA201990678A1 (ru) 2019-09-30
EA038128B1 EA038128B1 (ru) 2021-07-09

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US (3) US10138241B2 (ru)
EP (1) EP3512833B1 (ru)
JP (1) JP6733050B2 (ru)
KR (1) KR102472736B1 (ru)
CN (1) CN110023290B (ru)
AR (1) AR109650A1 (ru)
AU (1) AU2017327539B2 (ru)
BR (1) BR112019003320B1 (ru)
CA (1) CA3037141A1 (ru)
CL (1) CL2019000476A1 (ru)
CO (1) CO2019001181A2 (ru)
CY (1) CY1123494T1 (ru)
DK (1) DK3512833T3 (ru)
EA (1) EA038128B1 (ru)
ES (1) ES2816003T3 (ru)
HR (1) HRP20201494T1 (ru)
HU (1) HUE051551T2 (ru)
IL (1) IL265062B (ru)
LT (1) LT3512833T (ru)
MA (1) MA46229B1 (ru)
MX (1) MX2019003026A (ru)
NZ (1) NZ750416A (ru)
PE (1) PE20190979A1 (ru)
PH (1) PH12019500497A1 (ru)
PL (1) PL3512833T3 (ru)
PT (1) PT3512833T (ru)
RS (1) RS60729B1 (ru)
SA (1) SA519401322B1 (ru)
SI (1) SI3512833T1 (ru)
TW (1) TWI749062B (ru)
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WO (1) WO2018052772A1 (ru)

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CN110023290A (zh) 2019-07-16
PT3512833T (pt) 2020-09-24
JP2019529407A (ja) 2019-10-17
HRP20201494T1 (hr) 2020-12-11
CN110023290B (zh) 2022-08-12
MA46229B1 (fr) 2020-10-28
AR109650A1 (es) 2019-01-09
KR102472736B1 (ko) 2022-12-02
WO2018052772A1 (en) 2018-03-22
JP6733050B2 (ja) 2020-07-29
IL265062B (en) 2021-04-29
EA038128B1 (ru) 2021-07-09
MX2019003026A (es) 2019-07-01
CL2019000476A1 (es) 2019-05-31
PL3512833T3 (pl) 2021-01-11
UA123287C2 (uk) 2021-03-10
CY1123494T1 (el) 2022-03-24
AU2017327539A1 (en) 2019-02-21
NZ750416A (en) 2022-04-29
ES2816003T3 (es) 2021-03-31
CA3037141A1 (en) 2018-03-22
BR112019003320B1 (pt) 2024-02-20
AU2017327539B2 (en) 2020-12-24
CO2019001181A2 (es) 2019-02-19
KR20190047046A (ko) 2019-05-07
MA46229A (fr) 2019-07-24
SA519401322B1 (ar) 2022-05-10
TWI749062B (zh) 2021-12-11
EP3512833A1 (en) 2019-07-24
US20190048000A1 (en) 2019-02-14
PH12019500497A1 (en) 2019-12-11
HUE051551T2 (hu) 2021-03-01
RS60729B1 (sr) 2020-09-30
PE20190979A1 (es) 2019-07-09
BR112019003320A2 (pt) 2019-06-04
LT3512833T (lt) 2020-10-12
EP3512833B1 (en) 2020-07-29
US20180072717A1 (en) 2018-03-15
US10138241B2 (en) 2018-11-27
US11130754B2 (en) 2021-09-28
TW201823227A (zh) 2018-07-01
US20220081437A1 (en) 2022-03-17
SI3512833T1 (sl) 2020-11-30
DK3512833T3 (da) 2020-10-12

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