SA519401322B1 - مركبات أريل كربوكساميد غير متجانسة كمثطبات لكيناز بروتين سيرين/ ثريونين متداخل مع المستقبل 2 - Google Patents

مركبات أريل كربوكساميد غير متجانسة كمثطبات لكيناز بروتين سيرين/ ثريونين متداخل مع المستقبل 2

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SA519401322B1
SA519401322B1 SA519401322A SA519401322A SA519401322B1 SA 519401322 B1 SA519401322 B1 SA 519401322B1 SA 519401322 A SA519401322 A SA 519401322A SA 519401322 A SA519401322 A SA 519401322A SA 519401322 B1 SA519401322 B1 SA 519401322B1
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Saudi Arabia
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inhibitors
receptor
protein kinase
threonine protein
carboxamide compounds
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SA519401322A
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English (en)
Inventor
انيل كيه باديانا
سابين روبيل
زهونجهوا زهانج
بينجرونج ليو
كرينج اندريو ميلير
ماولين يو
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بوهرينجر انجلهيم انترناشونال جى ام بى اتش
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Publication of SA519401322B1 publication Critical patent/SA519401322B1/ar

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

يتعلق الاختراع الحالي بمركبات بالصيغة (I): I أو أملاح مقبولة صيدلانياً منها، حيث R1، R2، X، Y، وHET هي كما تم تعريفها في هذه الوثيقة. يتعلق الاختراع أيضاً بتركيبات صيدلانية تشتمل على هذه المركبات، طرق استخدام هذه المركبات في معالجة الأمراض والاضطرابات المختلفة، عمليات لتحضير هذه المركبات والمركبات الوسيطة المفيدة في هذه العمليات.
SA519401322A 2016-09-15 2019-03-14 مركبات أريل كربوكساميد غير متجانسة كمثطبات لكيناز بروتين سيرين/ ثريونين متداخل مع المستقبل 2 SA519401322B1 (ar)

Applications Claiming Priority (2)

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US201662394779P 2016-09-15 2016-09-15
PCT/US2017/050197 WO2018052772A1 (en) 2016-09-15 2017-09-06 Heteroaryl carboxamide compounds as inhibitors of ripk2

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SA519401322B1 true SA519401322B1 (ar) 2022-05-10

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US (3) US10138241B2 (ar)
EP (1) EP3512833B1 (ar)
JP (1) JP6733050B2 (ar)
KR (1) KR102472736B1 (ar)
CN (1) CN110023290B (ar)
AR (1) AR109650A1 (ar)
AU (1) AU2017327539B2 (ar)
BR (1) BR112019003320B1 (ar)
CA (1) CA3037141A1 (ar)
CL (1) CL2019000476A1 (ar)
CO (1) CO2019001181A2 (ar)
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PL (1) PL3512833T3 (ar)
PT (1) PT3512833T (ar)
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CN110023290A (zh) 2019-07-16
PT3512833T (pt) 2020-09-24
JP2019529407A (ja) 2019-10-17
HRP20201494T1 (hr) 2020-12-11
CN110023290B (zh) 2022-08-12
MA46229B1 (fr) 2020-10-28
AR109650A1 (es) 2019-01-09
KR102472736B1 (ko) 2022-12-02
EA201990678A1 (ru) 2019-09-30
WO2018052772A1 (en) 2018-03-22
JP6733050B2 (ja) 2020-07-29
IL265062B (en) 2021-04-29
EA038128B1 (ru) 2021-07-09
MX2019003026A (es) 2019-07-01
CL2019000476A1 (es) 2019-05-31
PL3512833T3 (pl) 2021-01-11
UA123287C2 (uk) 2021-03-10
CY1123494T1 (el) 2022-03-24
AU2017327539A1 (en) 2019-02-21
NZ750416A (en) 2022-04-29
ES2816003T3 (es) 2021-03-31
CA3037141A1 (en) 2018-03-22
BR112019003320B1 (pt) 2024-02-20
AU2017327539B2 (en) 2020-12-24
CO2019001181A2 (es) 2019-02-19
KR20190047046A (ko) 2019-05-07
MA46229A (fr) 2019-07-24
TWI749062B (zh) 2021-12-11
EP3512833A1 (en) 2019-07-24
US20190048000A1 (en) 2019-02-14
PH12019500497A1 (en) 2019-12-11
HUE051551T2 (hu) 2021-03-01
RS60729B1 (sr) 2020-09-30
PE20190979A1 (es) 2019-07-09
BR112019003320A2 (pt) 2019-06-04
LT3512833T (lt) 2020-10-12
EP3512833B1 (en) 2020-07-29
US20180072717A1 (en) 2018-03-15
US10138241B2 (en) 2018-11-27
US11130754B2 (en) 2021-09-28
TW201823227A (zh) 2018-07-01
US20220081437A1 (en) 2022-03-17
SI3512833T1 (sl) 2020-11-30
DK3512833T3 (da) 2020-10-12

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