MX2018013191A - Compuestos de pirimidina como inhibidores de la quinasa jak. - Google Patents
Compuestos de pirimidina como inhibidores de la quinasa jak.Info
- Publication number
- MX2018013191A MX2018013191A MX2018013191A MX2018013191A MX2018013191A MX 2018013191 A MX2018013191 A MX 2018013191A MX 2018013191 A MX2018013191 A MX 2018013191A MX 2018013191 A MX2018013191 A MX 2018013191A MX 2018013191 A MX2018013191 A MX 2018013191A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- kinase inhibitors
- pyrimidine compounds
- jak kinase
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La invención provee compuestos de fórmula (I): (ver Fórmula) donde las variables se definen en la memoria descriptiva, o una sal farmacéuticamente aceptable de los mismos, que son inhibidores de las quinasas JAK. La invención también provee composiciones farmacéuticas que comprenden tales compuestos, métodos de uso de tales compuestos para tratar enfermedades gastrointestinales y otras enfermedades inflamatorias, y procesos e intermediarios útiles para preparar tales compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662328737P | 2016-04-28 | 2016-04-28 | |
PCT/US2017/029796 WO2017189822A1 (en) | 2016-04-28 | 2017-04-27 | Pyrimidine compounds as jak kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018013191A true MX2018013191A (es) | 2019-02-13 |
Family
ID=58672793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018013191A MX2018013191A (es) | 2016-04-28 | 2017-04-27 | Compuestos de pirimidina como inhibidores de la quinasa jak. |
Country Status (20)
Country | Link |
---|---|
US (3) | US10028960B2 (es) |
EP (1) | EP3433253B1 (es) |
JP (1) | JP6881879B2 (es) |
KR (1) | KR102244257B1 (es) |
CN (1) | CN109071529B (es) |
AU (1) | AU2017258186B2 (es) |
BR (1) | BR112018072168A2 (es) |
CA (1) | CA3020506A1 (es) |
CL (1) | CL2018003060A1 (es) |
CO (1) | CO2018011408A2 (es) |
DK (1) | DK3433253T3 (es) |
EA (1) | EA035226B1 (es) |
ES (1) | ES2779880T3 (es) |
IL (1) | IL262386B (es) |
MX (1) | MX2018013191A (es) |
PT (1) | PT3433253T (es) |
SG (1) | SG11201809342YA (es) |
TW (1) | TWI726094B (es) |
WO (1) | WO2017189822A1 (es) |
ZA (1) | ZA201807179B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3303348T (pt) | 2015-05-28 | 2019-11-15 | Theravance Biopharma R&D Ip Llc | Compostos de naftiridina como inibidores da jak cinase |
DK3371185T3 (da) | 2015-11-03 | 2020-11-30 | Topivert Pharma Ltd | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer |
EP3712152B1 (en) | 2015-11-03 | 2021-01-13 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
US10028960B2 (en) | 2016-04-28 | 2018-07-24 | Theravance Biopharma R&D Ip, Llc | Pyrimidine compounds as JAK kinase inhibitors |
JP7218364B2 (ja) | 2017-10-27 | 2023-02-06 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | Jakキナーゼ阻害剤としてのピリミジン化合物 |
WO2019246273A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor |
TWI740288B (zh) * | 2018-11-27 | 2021-09-21 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
TWI741423B (zh) * | 2018-11-30 | 2021-10-01 | 大陸商江蘇豪森藥業集團有限公司 | 雜芳類衍生物調節劑、其製備方法和應用 |
AR118768A1 (es) | 2019-04-24 | 2021-10-27 | Theravance Biopharma R&D Ip Llc | Derivados de pirimidina como inhibidores de las cinasas jak |
US11439641B2 (en) | 2019-04-24 | 2022-09-13 | Theravance Biopharma R&D Ip, Llc | Pyrimidine JAK inhibitors for the treatment of skin diseases |
JP2023528239A (ja) * | 2020-05-14 | 2023-07-04 | テラバンス バイオファーマ アールアンドディー アイピー リミテッド ライアビリティ カンパニー | 腸管選択的jak3阻害剤の投与 |
WO2022083687A1 (zh) * | 2020-10-21 | 2022-04-28 | 南京明德新药研发有限公司 | 硒杂环类化合物及其应用 |
WO2023011359A1 (zh) * | 2021-08-05 | 2023-02-09 | 南京明德新药研发有限公司 | 桥环类化合物及其应用 |
CN113883920B (zh) * | 2021-10-25 | 2024-01-23 | 安徽华铂再生资源科技有限公司 | 一种降低空分装置空冷塔出口温度的方法 |
WO2023202706A1 (zh) * | 2022-04-21 | 2023-10-26 | 南京明德新药研发有限公司 | 硒杂环类化合物的盐型和晶型及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
BR0116411A (pt) | 2000-12-21 | 2003-11-11 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
EP1841760B1 (en) * | 2004-12-30 | 2011-08-10 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
CA2629781A1 (en) | 2005-11-16 | 2007-05-24 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
AU2007263655A1 (en) | 2006-06-30 | 2008-01-03 | Astrazeneca Ab | Pyrimidine derivatives useful in the treatment of cancer |
US8222256B2 (en) | 2006-07-05 | 2012-07-17 | Exelixis, Inc. | Methods of using IGFIR and ABL kinase modulators |
CN104011050A (zh) | 2011-12-22 | 2014-08-27 | 霍夫曼-拉罗奇有限公司 | 作为丝氨酸/苏氨酸激酶抑制剂的2,4-二氨基-嘧啶衍生物 |
WO2015094803A1 (en) * | 2013-12-16 | 2015-06-25 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
NO2721710T3 (es) * | 2014-08-21 | 2018-03-31 | ||
PT3303348T (pt) | 2015-05-28 | 2019-11-15 | Theravance Biopharma R&D Ip Llc | Compostos de naftiridina como inibidores da jak cinase |
US10028960B2 (en) * | 2016-04-28 | 2018-07-24 | Theravance Biopharma R&D Ip, Llc | Pyrimidine compounds as JAK kinase inhibitors |
-
2017
- 2017-04-27 US US15/498,803 patent/US10028960B2/en not_active Expired - Fee Related
- 2017-04-27 EA EA201892436A patent/EA035226B1/ru unknown
- 2017-04-27 WO PCT/US2017/029796 patent/WO2017189822A1/en active Application Filing
- 2017-04-27 DK DK17722324.5T patent/DK3433253T3/da active
- 2017-04-27 TW TW106114033A patent/TWI726094B/zh not_active IP Right Cessation
- 2017-04-27 CA CA3020506A patent/CA3020506A1/en not_active Abandoned
- 2017-04-27 PT PT177223245T patent/PT3433253T/pt unknown
- 2017-04-27 MX MX2018013191A patent/MX2018013191A/es active IP Right Grant
- 2017-04-27 AU AU2017258186A patent/AU2017258186B2/en not_active Ceased
- 2017-04-27 BR BR112018072168-9A patent/BR112018072168A2/pt not_active Application Discontinuation
- 2017-04-27 ES ES17722324T patent/ES2779880T3/es active Active
- 2017-04-27 CN CN201780026437.4A patent/CN109071529B/zh not_active Expired - Fee Related
- 2017-04-27 EP EP17722324.5A patent/EP3433253B1/en active Active
- 2017-04-27 KR KR1020187034319A patent/KR102244257B1/ko active IP Right Grant
- 2017-04-27 SG SG11201809342YA patent/SG11201809342YA/en unknown
- 2017-04-27 JP JP2018555938A patent/JP6881879B2/ja active Active
-
2018
- 2018-06-21 US US16/014,233 patent/US10485803B2/en active Active
- 2018-10-15 IL IL262386A patent/IL262386B/en unknown
- 2018-10-25 CO CONC2018/0011408A patent/CO2018011408A2/es unknown
- 2018-10-26 CL CL2018003060A patent/CL2018003060A1/es unknown
- 2018-10-26 ZA ZA2018/07179A patent/ZA201807179B/en unknown
-
2019
- 2019-10-18 US US16/656,927 patent/US11110095B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2017258186B2 (en) | 2020-09-17 |
US11110095B2 (en) | 2021-09-07 |
US20180303836A1 (en) | 2018-10-25 |
PT3433253T (pt) | 2020-04-30 |
CA3020506A1 (en) | 2017-11-02 |
ZA201807179B (en) | 2019-08-28 |
IL262386B (en) | 2021-08-31 |
EP3433253B1 (en) | 2020-02-12 |
US10028960B2 (en) | 2018-07-24 |
CL2018003060A1 (es) | 2018-12-14 |
EA201892436A1 (ru) | 2019-04-30 |
WO2017189822A1 (en) | 2017-11-02 |
EA035226B1 (ru) | 2020-05-19 |
DK3433253T3 (da) | 2020-04-06 |
KR20190002591A (ko) | 2019-01-08 |
AU2017258186A1 (en) | 2018-11-15 |
JP6881879B2 (ja) | 2021-06-02 |
TW201739747A (zh) | 2017-11-16 |
CO2018011408A2 (es) | 2018-11-13 |
KR102244257B1 (ko) | 2021-04-26 |
ES2779880T3 (es) | 2020-08-20 |
US20200046709A1 (en) | 2020-02-13 |
SG11201809342YA (en) | 2018-11-29 |
IL262386A (en) | 2018-11-29 |
JP2019514903A (ja) | 2019-06-06 |
CN109071529B (zh) | 2021-08-06 |
TWI726094B (zh) | 2021-05-01 |
US10485803B2 (en) | 2019-11-26 |
EP3433253A1 (en) | 2019-01-30 |
BR112018072168A2 (pt) | 2019-02-12 |
CN109071529A (zh) | 2018-12-21 |
US20170312280A1 (en) | 2017-11-02 |
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Legal Events
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FG | Grant or registration |