DK3371185T3 - 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer - Google Patents
4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer Download PDFInfo
- Publication number
- DK3371185T3 DK3371185T3 DK16793974.3T DK16793974T DK3371185T3 DK 3371185 T3 DK3371185 T3 DK 3371185T3 DK 16793974 T DK16793974 T DK 16793974T DK 3371185 T3 DK3371185 T3 DK 3371185T3
- Authority
- DK
- Denmark
- Prior art keywords
- chinase
- hexahydroimidazo
- janus
- imidazo
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1519382.4A GB201519382D0 (en) | 2015-11-03 | 2015-11-03 | Kinase inhibitors |
GB201606971 | 2016-04-21 | ||
PCT/GB2016/053392 WO2017077288A1 (en) | 2015-11-03 | 2016-11-02 | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3371185T3 true DK3371185T3 (da) | 2020-11-30 |
Family
ID=57256357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16793974.3T DK3371185T3 (da) | 2015-11-03 | 2016-11-02 | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer |
Country Status (8)
Country | Link |
---|---|
US (2) | US10556901B2 (da) |
EP (2) | EP3831830A1 (da) |
CA (1) | CA3037248A1 (da) |
DK (1) | DK3371185T3 (da) |
ES (1) | ES2840650T3 (da) |
PL (1) | PL3371185T3 (da) |
PT (1) | PT3371185T (da) |
WO (1) | WO2017077288A1 (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017077283A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
US10556901B2 (en) | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
CA3001542C (en) | 2015-11-03 | 2021-02-16 | Theravance Biopharma R&D Ip, Llc | Jak kinase inhibitor compounds for treatment of respiratory disease |
PT3592742T (pt) * | 2017-03-09 | 2021-07-30 | Theravance Biopharma R&D Ip Llc | Inibidores de jak contendo uma amida heterocíclica com 4 membros |
SG11201909376TA (en) | 2017-05-01 | 2019-11-28 | Theravance Biopharma R&D Ip Llc | Crystalline forms of a jak inhibitor compound |
BR112019022665A2 (pt) | 2017-05-01 | 2020-05-19 | Theravance Biopharma R&D Ip Llc | métodos de tratamento usando um composto inibidor de jak |
AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
ES2955717T3 (es) * | 2018-09-04 | 2023-12-05 | Theravance Biopharma R&D Ip Llc | Amidas heterocíclicas de 5 a 7 elementos como inhibidores de JAK |
CN112638902A (zh) | 2018-09-04 | 2021-04-09 | 施万生物制药研发Ip有限责任公司 | 用于制备jak抑制剂的方法及其中间体 |
US10947229B2 (en) | 2018-09-04 | 2021-03-16 | Theravance Biopharma R&D Ip, Llc | Dimethyl amino azetidine amides as JAK inhibitors |
CA3113667A1 (en) | 2018-10-29 | 2020-05-07 | Theravance Biopharma R&D Ip, Llc | 2-azabicyclo hexane compound as jak inhibitor |
JP2022518741A (ja) | 2019-01-23 | 2022-03-16 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | JAKキナーゼ阻害剤としてのイミダゾ[1,5-a]ピリジン、1,2,4-トリアゾロ[4,3-a]ピリジンおよびイミダゾ[1,5-a]ピラジン |
CN114075200A (zh) * | 2020-08-14 | 2022-02-22 | 河南迈英诺医药科技有限公司 | 用于治疗重症肺炎的jak抑制剂化合物 |
CN114075199A (zh) * | 2020-08-14 | 2022-02-22 | 河南迈英诺医药科技有限公司 | Jak抑制剂化合物及其用途 |
BR112021016751B8 (pt) | 2019-02-25 | 2023-11-21 | Henan Medinno Pharmaceutical Tech Co Ltd | Compostos, composições farmacêuticas e usos dos compostos |
TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
CN117343063A (zh) * | 2022-07-04 | 2024-01-05 | 河南迈英诺医药科技有限公司 | 作为trk抑制剂和/或ret抑制剂的化合物及其用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
EP2175858B1 (en) | 2007-07-11 | 2014-09-10 | Pfizer Inc. | Pharmaceutical compositions and methods of treating dry eye disorders |
US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
FR2981917B1 (fr) | 2011-10-26 | 2013-11-15 | Cadorit Ag | Recipient pour emballer un premier fluide et un deuxieme fluide |
AU2013277637C1 (en) | 2012-06-22 | 2019-10-24 | Mimetogen Pharmaceuticals Inc. | Synthesis of beta-turn peptidomimetic cyclic compounds |
AU2015260905A1 (en) | 2014-05-14 | 2016-12-01 | Pfizer Inc. | Pyrazolopyridines and pyrazolopyrimidines |
EP3303348B1 (en) | 2015-05-28 | 2019-08-07 | Theravance Biopharma R&D IP, LLC | Naphthyridine compounds as jak kinase inhibitors |
US10556901B2 (en) | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
CA3001542C (en) | 2015-11-03 | 2021-02-16 | Theravance Biopharma R&D Ip, Llc | Jak kinase inhibitor compounds for treatment of respiratory disease |
WO2017077283A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
TWI703147B (zh) | 2015-11-24 | 2020-09-01 | 美商施萬生物製藥研發Ip有限責任公司 | 用於治療胃腸發炎性疾病之jak抑制劑化合物之前藥 |
EA035226B1 (ru) | 2016-04-28 | 2020-05-19 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Пиримидиновые соединения в качестве ингибиторов jak киназы |
PT3592742T (pt) * | 2017-03-09 | 2021-07-30 | Theravance Biopharma R&D Ip Llc | Inibidores de jak contendo uma amida heterocíclica com 4 membros |
-
2016
- 2016-11-02 US US15/772,887 patent/US10556901B2/en not_active Expired - Fee Related
- 2016-11-02 PL PL16793974T patent/PL3371185T3/pl unknown
- 2016-11-02 WO PCT/GB2016/053392 patent/WO2017077288A1/en active Application Filing
- 2016-11-02 DK DK16793974.3T patent/DK3371185T3/da active
- 2016-11-02 EP EP20199005.8A patent/EP3831830A1/en not_active Withdrawn
- 2016-11-02 EP EP16793974.3A patent/EP3371185B1/en active Active
- 2016-11-02 ES ES16793974T patent/ES2840650T3/es active Active
- 2016-11-02 PT PT167939743T patent/PT3371185T/pt unknown
- 2016-11-02 CA CA3037248A patent/CA3037248A1/en not_active Abandoned
-
2019
- 2019-12-11 US US16/710,074 patent/US10882859B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
PT3371185T (pt) | 2020-12-28 |
EP3831830A1 (en) | 2021-06-09 |
WO2017077288A1 (en) | 2017-05-11 |
CA3037248A1 (en) | 2017-05-11 |
PL3371185T3 (pl) | 2021-04-06 |
EP3371185A1 (en) | 2018-09-12 |
US10882859B2 (en) | 2021-01-05 |
US20180370963A1 (en) | 2018-12-27 |
ES2840650T3 (es) | 2021-07-07 |
US10556901B2 (en) | 2020-02-11 |
US20200223843A1 (en) | 2020-07-16 |
EP3371185B1 (en) | 2020-09-30 |
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