AR118768A1 - Derivados de pirimidina como inhibidores de las cinasas jak - Google Patents

Derivados de pirimidina como inhibidores de las cinasas jak

Info

Publication number
AR118768A1
AR118768A1 ARP200101152A ARP200101152A AR118768A1 AR 118768 A1 AR118768 A1 AR 118768A1 AR P200101152 A ARP200101152 A AR P200101152A AR P200101152 A ARP200101152 A AR P200101152A AR 118768 A1 AR118768 A1 AR 118768A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
inhibitors
pyrimidine derivatives
jak kinases
Prior art date
Application number
ARP200101152A
Other languages
English (en)
Inventor
Daniel D Long
Jianhua Chao
Philip A Gerken
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of AR118768A1 publication Critical patent/AR118768A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

Compuestos ésteres derivados de pirimidinas sustituidas como inhibidores de JAK, composiciones farmacéuticas que los comprenden y su uso para el tratamiento de enfermedades inflamatorias y autoinmunes cutáneas tales como psoriasis, vitiligo y lupus discoide. Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable de este; caracterizado porque X es -O- o un enlace; R se selecciona del grupo que consiste en C₁₋₈ alquilo, un grupo heterocíclico de 4 a 7 miembros, y un grupo cicloalquilo de 3 a 8 miembros, donde los grupos C₁₋₈ alquilo, heterocíclico y cicloalquilo están sustituidos opcionalmente con 1 a 3 Rᵃ; y cada Rᵃ se selecciona independientemente del grupo que consiste en C₁₋₄ alquilo, CN, F, OH, C₁₋₄ alquilo-OH y C₁₋₄ alcoxi.
ARP200101152A 2019-04-24 2020-04-23 Derivados de pirimidina como inhibidores de las cinasas jak AR118768A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962837829P 2019-04-24 2019-04-24

Publications (1)

Publication Number Publication Date
AR118768A1 true AR118768A1 (es) 2021-10-27

Family

ID=70740750

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200101152A AR118768A1 (es) 2019-04-24 2020-04-23 Derivados de pirimidina como inhibidores de las cinasas jak

Country Status (7)

Country Link
US (2) US11155549B2 (es)
EP (1) EP3958969B1 (es)
JP (1) JP7470713B2 (es)
AR (1) AR118768A1 (es)
CA (1) CA3135383A1 (es)
TW (1) TW202106682A (es)
WO (1) WO2020219639A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102613503B1 (ko) 2017-10-27 2023-12-13 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 키나제 저해제로서 피리미딘 화합물
AR118768A1 (es) * 2019-04-24 2021-10-27 Theravance Biopharma R&D Ip Llc Derivados de pirimidina como inhibidores de las cinasas jak
EP3959213A1 (en) * 2019-04-24 2022-03-02 Theravance Biopharma R&D IP, LLC Pyrimidine jak inhibitors for the treatment of skin diseases
US20210212962A1 (en) * 2020-01-13 2021-07-15 Sol-Gel Technologies Ltd. Methods and compositions for the treatment of granuloma annulare or subcutaneous inflammation and non-infection granulomatous diseases
AU2022263067A1 (en) * 2021-04-22 2023-11-02 Shenzhen Chipscreen Biosciences Co., Ltd. Pharmaceutical composition containing jak3/jak1/tbk1 selective inhibitor and medical use thereof

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US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
CA2422371C (en) 2000-09-15 2010-05-18 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US20030105090A1 (en) 2000-12-21 2003-06-05 David Bebbington Pyrazole compounds useful as protein kinase inhibitors
CN101360740A (zh) 2005-11-16 2009-02-04 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶
EP2044063A1 (en) 2006-06-30 2009-04-08 Astra Zeneca AB Pyrimidine derivatives useful in the treatment of cancer
US8222256B2 (en) 2006-07-05 2012-07-17 Exelixis, Inc. Methods of using IGFIR and ABL kinase modulators
BR112014015549A8 (pt) 2011-12-22 2017-07-04 Hoffmann La Roche composto, método de inibição da atividade pak1, método para o tratamento, processo, composição, utilização de um composto e invenção
WO2015094803A1 (en) 2013-12-16 2015-06-25 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
NO2721710T3 (es) * 2014-08-21 2018-03-31
EP3303348B1 (en) * 2015-05-28 2019-08-07 Theravance Biopharma R&D IP, LLC Naphthyridine compounds as jak kinase inhibitors
KR102244257B1 (ko) 2016-04-28 2021-04-26 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 키나제 저해제로서 피리미딘 화합물
KR102613503B1 (ko) 2017-10-27 2023-12-13 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 키나제 저해제로서 피리미딘 화합물
WO2020108516A1 (zh) 2018-11-27 2020-06-04 江苏豪森药业集团有限公司 含氮杂芳类衍生物调节剂、其制备方法和应用
JP2022510980A (ja) 2018-11-30 2022-01-28 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 ヘテロ芳香族誘導体調節因子、その製造方法及び使用
AR118768A1 (es) * 2019-04-24 2021-10-27 Theravance Biopharma R&D Ip Llc Derivados de pirimidina como inhibidores de las cinasas jak
EP3959213A1 (en) 2019-04-24 2022-03-02 Theravance Biopharma R&D IP, LLC Pyrimidine jak inhibitors for the treatment of skin diseases
CN113372364A (zh) 2020-03-10 2021-09-10 明慧医药（上海）有限公司 一类jak激酶抑制剂及其制备和应用
CN113372351A (zh) 2020-03-10 2021-09-10 明慧医药（杭州）有限公司 一类jak激酶抑制剂及其制备和应用

Also Published As

Publication number Publication date
JP2022529370A (ja) 2022-06-21
US20200339580A1 (en) 2020-10-29
US20220009926A1 (en) 2022-01-13
CA3135383A1 (en) 2020-10-29
US11155549B2 (en) 2021-10-26
EP3958969B1 (en) 2024-01-10
JP7470713B2 (ja) 2024-04-18
TW202106682A (zh) 2021-02-16
EP3958969A1 (en) 2022-03-02
EP3958969C0 (en) 2024-01-10
WO2020219639A1 (en) 2020-10-29
US11845747B2 (en) 2023-12-19

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