PE20200341A1 - Composiciones y compuestos terapeuticos y metodos para utilizarlos - Google Patents

Composiciones y compuestos terapeuticos y metodos para utilizarlos

Info

Publication number
PE20200341A1
PE20200341A1 PE2019001932A PE2019001932A PE20200341A1 PE 20200341 A1 PE20200341 A1 PE 20200341A1 PE 2019001932 A PE2019001932 A PE 2019001932A PE 2019001932 A PE2019001932 A PE 2019001932A PE 20200341 A1 PE20200341 A1 PE 20200341A1
Authority
PE
Peru
Prior art keywords
compositions
methods
therapeutic compounds
compound
pharmaceutically acceptable
Prior art date
Application number
PE2019001932A
Other languages
English (en)
Inventor
Mark Zak
F Anthony Romero
Yun-Xing Cheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20200341A1 publication Critical patent/PE20200341A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Referido a un compuesto de formula I, o una sal o estereoisomero farmaceuticamente aceptable de ese, en donde R1 es H o CH3; R2 es halogeno, alquilo C1-C6, alquenilo C2-C6, entre otros; R3 es H o NH2; R4 es H o CH3 y R5 es H o NH2. Este compuesto es inhibidor de JAK cinasa. Tambien se refiere a composiciones farmaceuticas que incluyen tal inhibidor JAK y un portador, adyuvante o vehiculo farmaceuticamente aceptable, y su uso en el tratamiento de enfermedad inflamatoria, como el asma.
PE2019001932A 2017-05-22 2018-05-21 Composiciones y compuestos terapeuticos y metodos para utilizarlos PE20200341A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017085276 2017-05-22
US201862640865P 2018-03-09 2018-03-09
PCT/EP2018/063262 WO2018215389A1 (en) 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
PE20200341A1 true PE20200341A1 (es) 2020-02-14

Family

ID=62386421

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001932A PE20200341A1 (es) 2017-05-22 2018-05-21 Composiciones y compuestos terapeuticos y metodos para utilizarlos

Country Status (19)

Country Link
US (3) US10307426B2 (es)
EP (1) EP3630766A1 (es)
JP (2) JP7256757B2 (es)
KR (1) KR20200010390A (es)
CN (1) CN110650959B (es)
AU (1) AU2018274577A1 (es)
BR (1) BR112019024322A2 (es)
CA (1) CA3061236A1 (es)
CL (1) CL2019003258A1 (es)
CO (1) CO2019010559A2 (es)
CR (1) CR20190520A (es)
MA (1) MA48942A (es)
MX (1) MX2019013308A (es)
PE (1) PE20200341A1 (es)
PH (1) PH12019502601A1 (es)
RU (1) RU2769696C2 (es)
SG (1) SG11201909735YA (es)
TW (1) TW201902896A (es)
WO (1) WO2018215389A1 (es)

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EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
EP3986899A1 (en) * 2019-06-18 2022-04-27 F. Hoffmann-La Roche AG Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
AU2020297415A1 (en) 2019-06-18 2022-01-06 F. Hoffmann-La Roche Ag Pyrazolopyrimidine sulfone inhibitors of JAK kinases and uses thereof
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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CN110678467B (zh) 2017-05-22 2023-06-13 豪夫迈·罗氏有限公司 治疗化合物和组合物及其使用方法

Also Published As

Publication number Publication date
RU2019141734A3 (es) 2021-08-10
US20200352951A1 (en) 2020-11-12
BR112019024322A2 (pt) 2020-06-16
WO2018215389A1 (en) 2018-11-29
PH12019502601A1 (en) 2020-06-08
CN110650959A (zh) 2020-01-03
TW201902896A (zh) 2019-01-16
US10307426B2 (en) 2019-06-04
US20190240227A1 (en) 2019-08-08
MX2019013308A (es) 2020-02-12
MA48942A (fr) 2020-04-08
KR20200010390A (ko) 2020-01-30
RU2769696C2 (ru) 2022-04-05
CL2019003258A1 (es) 2020-04-17
US20180333416A1 (en) 2018-11-22
CA3061236A1 (en) 2018-11-29
RU2019141734A (ru) 2021-06-23
JP2020520959A (ja) 2020-07-16
SG11201909735YA (en) 2019-11-28
CR20190520A (es) 2020-01-21
JP7256757B2 (ja) 2023-04-12
AU2018274577A1 (en) 2019-10-10
CO2019010559A2 (es) 2019-10-09
EP3630766A1 (en) 2020-04-08
JP2023058657A (ja) 2023-04-25
CN110650959B (zh) 2023-04-18

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