PE20190656A1 - Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 - Google Patents

Compuestos de tiazolo-piridina sustituida como inhibidores de malt1

Info

Publication number
PE20190656A1
PE20190656A1 PE2019000282A PE2019000282A PE20190656A1 PE 20190656 A1 PE20190656 A1 PE 20190656A1 PE 2019000282 A PE2019000282 A PE 2019000282A PE 2019000282 A PE2019000282 A PE 2019000282A PE 20190656 A1 PE20190656 A1 PE 20190656A1
Authority
PE
Peru
Prior art keywords
malt1
inhibitors
pyridine compounds
tiazolo
compounds replaced
Prior art date
Application number
PE2019000282A
Other languages
English (en)
Inventor
Gagan Kukreja
Nageswara Rao Irlapati
Arun Rangnath Jagdale
Gokul Keruji Deshmukh
Vinod Popatrao Vyavahare
Kiran Chandrashekhar Kulkarni
Neelima Sinha
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of PE20190656A1 publication Critical patent/PE20190656A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

Referido a compuestos de tiazolo-piridina sustituida, de formula (I), en el que R1 se selecciona de H, halogeno, ciano, entre otros; R2 se selecciona de alquilo, alquilo sustituido, cicloalquilo, entre otros; R3 se selecciona de heteroarilo, heteroarilo sustituido, arilo, entre otros. Un compuesto seleccionado es 1-(5-cloro-6-metoxipiridin-3-il)-3-(7-ciclopropil-2-metiltiazolo[5,4-b]piridin-6-il)urea. Ademas, se refiere a su uso como inhibidores de MALT1 en el tratamiento de enfermedades o trastornos inflamatorios y autoinmunes, como el cancer; metodos para sintetizar dichos compuestos y composiciones farmaceuticas que los contiene.
PE2019000282A 2016-07-29 2017-07-28 Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 PE20190656A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201621026107 2016-07-29

Publications (1)

Publication Number Publication Date
PE20190656A1 true PE20190656A1 (es) 2019-05-08

Family

ID=59745317

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019000282A PE20190656A1 (es) 2016-07-29 2017-07-28 Compuestos de tiazolo-piridina sustituida como inhibidores de malt1

Country Status (15)

Country Link
US (1) US20190275012A9 (es)
JP (1) JP2019522035A (es)
KR (1) KR20190033607A (es)
CN (1) CN110312724A (es)
AU (1) AU2017302182B2 (es)
CA (1) CA3032334A1 (es)
CL (1) CL2019000221A1 (es)
DO (1) DOP2019000020A (es)
IL (1) IL289474A (es)
MX (1) MX2019001132A (es)
PE (1) PE20190656A1 (es)
PH (1) PH12019500214A1 (es)
RU (1) RU2019104890A (es)
SG (1) SG11201900745VA (es)
WO (1) WO2018020474A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11248007B2 (en) 2017-03-08 2022-02-15 Cornell University Inhibitors of MALT1 and uses thereof
JP7271540B2 (ja) * 2017-11-17 2023-05-11 へパジーン セラピューティクス （エイチケイ） リミテッド Ａｓｋ１阻害剤としての尿素誘導体
AU2019289223B2 (en) 2018-06-18 2023-09-21 Janssen Pharmaceutica Nv Pyrazole derivatives as MALT1 inhibitors
BR112020025844A2 (pt) 2018-06-18 2021-03-23 Janssen Pharmaceutica Nv derivados de pirazol como inibidores de malt1
CN109265453A (zh) * 2018-10-23 2019-01-25 华侨大学 一种用作caspase-3激活剂的缩氨基脲类衍生物及其应用
IL303962A (en) 2018-11-28 2023-08-01 Takeda Pharmaceuticals Co The tricyclic compound
MA55593A (fr) * 2019-04-11 2022-02-16 Janssen Pharmaceutica Nv Cycles pyridine contenant des dérivés servant d'inhibiteurs de malt1
WO2021000855A1 (en) * 2019-07-01 2021-01-07 Qilu Regor Therapeutics Inc. Malt1 inhibitors and uses thereof
WO2021063735A1 (en) * 2019-10-02 2021-04-08 Basf Se New bicyclic pyridine derivatives
CA3161339A1 (en) * 2019-12-27 2021-07-01 Schrodinger, Inc. Cyclic compounds and methods of using same
US20230192685A1 (en) 2020-05-27 2023-06-22 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
WO2021262969A1 (en) 2020-06-24 2021-12-30 The General Hospital Corporation Materials and methods of treating cancer
CN116710089A (zh) * 2020-11-12 2023-09-05 莫诺泰罗斯疗法公司 治疗癌症的材料和方法
WO2023148501A1 (en) 2022-02-03 2023-08-10 C4X Discovery Limited Heterocyclic derivatives as malt1 inhibitors
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑
WO2023192506A1 (en) * 2022-03-31 2023-10-05 Rarified Biosciences, Inc. Malt1 modulators and uses thereof

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US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
PL355148A1 (en) * 1999-11-05 2004-04-05 Warner-Lambert Company Prevention of plaque rupture by acat inhibitors
AU2003222667A1 (en) * 2002-04-23 2003-11-10 Chugai Seiyaku Kabushiki Kaisha 1,3-thiazoles as lxr modulators in the treatment of cardiovascular diseases
WO2008146259A2 (en) 2007-06-01 2008-12-04 University Of Lausanne Malt1 specific cleavage in assay and screening method
ATE553769T1 (de) 2007-11-21 2012-05-15 Vib Vzw Inhibitoren der malt1-proteolytischen aktivität und ihre verwendung
KR20140049028A (ko) * 2011-07-26 2014-04-24 그뤼넨탈 게엠베하 바닐로이드 수용체 리간드로서의 치환된 바이사이클릭 방향족 카복스아미드 및 우레아 유도체
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CN105188376B (zh) 2012-11-09 2017-12-01 康奈尔大学 Malt1的小分子抑制剂
WO2014086478A1 (en) 2012-12-03 2014-06-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of malt1 protease
EP4001275A1 (en) 2013-06-26 2022-05-25 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH (s)-enantiomer of mepazine as paracaspase (malt1) inhibitor for the treatment of cancer
EP3097124B1 (en) 2014-01-21 2018-12-19 Helmholtz Zentrum München Means and methods for detecting activated malt1
WO2015181747A1 (en) * 2014-05-28 2015-12-03 Novartis Ag Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors
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US10711036B2 (en) 2015-08-28 2020-07-14 Cornell University MALT1 inhibitors and uses thereof
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US11248007B2 (en) * 2017-03-08 2022-02-15 Cornell University Inhibitors of MALT1 and uses thereof

Also Published As

Publication number Publication date
IL289474A (en) 2022-02-01
JP2019522035A (ja) 2019-08-08
CA3032334A1 (en) 2018-02-01
PH12019500214A1 (en) 2019-10-28
RU2019104890A (ru) 2020-08-31
US20190275012A9 (en) 2019-09-12
CN110312724A (zh) 2019-10-08
CL2019000221A1 (es) 2019-06-07
RU2019104890A3 (es) 2020-08-31
WO2018020474A1 (en) 2018-02-01
AU2017302182A1 (en) 2019-03-07
US20190160045A1 (en) 2019-05-30
KR20190033607A (ko) 2019-03-29
MX2019001132A (es) 2019-12-16
DOP2019000020A (es) 2019-04-30
AU2017302182B2 (en) 2021-11-04
SG11201900745VA (en) 2019-02-27

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