CU20180028A7 - DERIVADOS DE IMIDAZO[4,5-b]PIRIDINA, ÚTILES COMO INHIBIDORES DUALES DE DYRK1/CLK1 Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN - Google Patents
DERIVADOS DE IMIDAZO[4,5-b]PIRIDINA, ÚTILES COMO INHIBIDORES DUALES DE DYRK1/CLK1 Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENENInfo
- Publication number
- CU20180028A7 CU20180028A7 CUP2018000028A CU20180028A CU20180028A7 CU 20180028 A7 CU20180028 A7 CU 20180028A7 CU P2018000028 A CUP2018000028 A CU P2018000028A CU 20180028 A CU20180028 A CU 20180028A CU 20180028 A7 CU20180028 A7 CU 20180028A7
- Authority
- CU
- Cuba
- Prior art keywords
- pharmaceutical compositions
- dyrk1
- piridine
- clk1
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
<p>La presente invención se refiere a compuestos de fórmula (I):<br /> ESPACIO PARA FÓRMULA</p> <p>en la que R1, R2, R3, R4 y R5 son como se definen en la descripción, así como a composiciones farmacéuticas que los contienen.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1559252A FR3041639B1 (fr) | 2015-09-30 | 2015-09-30 | NOUVEAUX DERIVES D'IMIDAZO[4,5-b]PYRIDINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
PCT/EP2016/073395 WO2017055530A1 (en) | 2015-09-30 | 2016-09-30 | New imidazo[4,5-b]pyridine derivatives as dual dyrk1/clk1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20180028A7 true CU20180028A7 (es) | 2018-07-05 |
Family
ID=54979755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2018000028A CU20180028A7 (es) | 2015-09-30 | 2016-09-30 | DERIVADOS DE IMIDAZO[4,5-b]PIRIDINA, ÚTILES COMO INHIBIDORES DUALES DE DYRK1/CLK1 Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN |
Country Status (26)
Country | Link |
---|---|
US (1) | US20180273528A1 (es) |
EP (1) | EP3356363A1 (es) |
JP (1) | JP2018535931A (es) |
KR (1) | KR20180054858A (es) |
CN (1) | CN108137581A (es) |
AU (1) | AU2016333505A1 (es) |
BR (1) | BR112018006157A2 (es) |
CA (1) | CA2999935A1 (es) |
CL (1) | CL2018000783A1 (es) |
CO (1) | CO2018003473A2 (es) |
CR (1) | CR20180181A (es) |
CU (1) | CU20180028A7 (es) |
DO (1) | DOP2018000083A (es) |
EA (1) | EA201890821A1 (es) |
EC (1) | ECSP18023253A (es) |
FR (1) | FR3041639B1 (es) |
HK (1) | HK1255804A1 (es) |
IL (1) | IL258341A (es) |
MA (1) | MA43020A (es) |
MX (1) | MX2018003860A (es) |
NI (1) | NI201800043A (es) |
PE (1) | PE20181331A1 (es) |
PH (1) | PH12018500650A1 (es) |
SV (1) | SV2018005657A (es) |
TN (1) | TN2018000090A1 (es) |
WO (1) | WO2017055530A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108822103A (zh) * | 2018-07-28 | 2018-11-16 | 刘凤娟 | 一种咪唑并[4,5-b]吡啶化合物及其制备方法和应用 |
EP3856186A4 (en) * | 2018-09-28 | 2022-07-06 | Arizona Board of Regents on behalf of the University of Arizona | SMALL MOLECULE DYRK1/CLK INHIBITORS AND THEIR USES |
WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
MX2021005047A (es) | 2018-10-31 | 2021-09-08 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1. |
EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
WO2021050824A1 (en) * | 2019-09-11 | 2021-03-18 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105189481A (zh) * | 2013-03-13 | 2015-12-23 | 艾伯维公司 | 吡啶cdk9激酶抑制剂 |
-
2015
- 2015-09-30 FR FR1559252A patent/FR3041639B1/fr not_active Expired - Fee Related
-
2016
- 2016-09-30 KR KR1020187012175A patent/KR20180054858A/ko unknown
- 2016-09-30 EA EA201890821A patent/EA201890821A1/ru unknown
- 2016-09-30 MA MA043020A patent/MA43020A/fr unknown
- 2016-09-30 PE PE2018000443A patent/PE20181331A1/es unknown
- 2016-09-30 JP JP2018516194A patent/JP2018535931A/ja active Pending
- 2016-09-30 AU AU2016333505A patent/AU2016333505A1/en not_active Abandoned
- 2016-09-30 CN CN201680058054.0A patent/CN108137581A/zh not_active Withdrawn
- 2016-09-30 TN TNP/2018/000090A patent/TN2018000090A1/en unknown
- 2016-09-30 CA CA2999935A patent/CA2999935A1/en not_active Abandoned
- 2016-09-30 WO PCT/EP2016/073395 patent/WO2017055530A1/en active Application Filing
- 2016-09-30 CU CUP2018000028A patent/CU20180028A7/es unknown
- 2016-09-30 CR CR20180181A patent/CR20180181A/es unknown
- 2016-09-30 EP EP16774682.5A patent/EP3356363A1/en not_active Withdrawn
- 2016-09-30 MX MX2018003860A patent/MX2018003860A/es unknown
- 2016-09-30 US US15/763,248 patent/US20180273528A1/en not_active Abandoned
- 2016-09-30 BR BR112018006157A patent/BR112018006157A2/pt not_active Application Discontinuation
-
2018
- 2018-03-22 SV SV2018005657A patent/SV2018005657A/es unknown
- 2018-03-23 PH PH12018500650A patent/PH12018500650A1/en unknown
- 2018-03-23 NI NI201800043A patent/NI201800043A/es unknown
- 2018-03-25 IL IL258341A patent/IL258341A/en unknown
- 2018-03-26 CL CL2018000783A patent/CL2018000783A1/es unknown
- 2018-03-26 EC ECIEPI201823253A patent/ECSP18023253A/es unknown
- 2018-03-27 DO DO2018000083A patent/DOP2018000083A/es unknown
- 2018-03-28 CO CONC2018/0003473A patent/CO2018003473A2/es unknown
- 2018-11-15 HK HK18114643.2A patent/HK1255804A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2017055530A1 (en) | 2017-04-06 |
IL258341A (en) | 2018-05-31 |
FR3041639B1 (fr) | 2019-01-25 |
CR20180181A (es) | 2018-06-22 |
MX2018003860A (es) | 2018-08-16 |
EP3356363A1 (en) | 2018-08-08 |
FR3041639A1 (es) | 2017-03-31 |
PE20181331A1 (es) | 2018-08-20 |
CL2018000783A1 (es) | 2018-09-21 |
US20180273528A1 (en) | 2018-09-27 |
AU2016333505A1 (en) | 2018-04-19 |
MA43020A (fr) | 2018-08-08 |
ECSP18023253A (es) | 2018-04-30 |
CO2018003473A2 (es) | 2018-07-10 |
HK1255804A1 (zh) | 2019-08-23 |
TN2018000090A1 (en) | 2019-07-08 |
SV2018005657A (es) | 2018-07-31 |
CN108137581A (zh) | 2018-06-08 |
CA2999935A1 (en) | 2017-04-06 |
EA201890821A1 (ru) | 2018-10-31 |
JP2018535931A (ja) | 2018-12-06 |
BR112018006157A2 (pt) | 2018-10-09 |
NI201800043A (es) | 2018-06-21 |
PH12018500650A1 (en) | 2018-10-01 |
DOP2018000083A (es) | 2018-10-15 |
KR20180054858A (ko) | 2018-05-24 |
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