MX2019001132A - Compuestos de tiazolo-piridina sustituida como inhibidores de malt1. - Google Patents

Compuestos de tiazolo-piridina sustituida como inhibidores de malt1.

Info

Publication number
MX2019001132A
MX2019001132A MX2019001132A MX2019001132A MX2019001132A MX 2019001132 A MX2019001132 A MX 2019001132A MX 2019001132 A MX2019001132 A MX 2019001132A MX 2019001132 A MX2019001132 A MX 2019001132A MX 2019001132 A MX2019001132 A MX 2019001132A
Authority
MX
Mexico
Prior art keywords
pyridine compounds
malt1 inhibitors
substituted thiazolo
disclosed
compounds
Prior art date
Application number
MX2019001132A
Other languages
English (en)
Inventor
Rao Irlapati Nageswara
Keruji Deshmukh Gokul
Kumar Kamboj Rajender
P Palle Venkata
Kukreja Gagan
Rangnath Jagdale Arun
Popatrao Vyavahare Vinod
Chandrashekhar Kulkarni Kiran
Sinha Neelma
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX2019001132A publication Critical patent/MX2019001132A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Se describen compuestos de la fórmula general (I), en donde R1-R3 son tal como se definen en la presente, para uso como inhibidores de MALT1 en el tratamiento de enfermedades o trastornos autoinmunes e inflamatorios. También se describen métodos para sintetizar los compuestos. También se describen composiciones farmacéuticas que contienen un compuesto de la invención y un método para tratar a un paciente por una enfermedad o trastorno autoinmune o inflamatorio, por ejemplo, un cáncer, mediante la administración de un compuesto de la invención.
MX2019001132A 2016-07-29 2017-07-28 Compuestos de tiazolo-piridina sustituida como inhibidores de malt1. MX2019001132A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621026107 2016-07-29
PCT/IB2017/054612 WO2018020474A1 (en) 2016-07-29 2017-07-28 Substituted thiazolo-pyridine compounds as malt1 inhibitors

Publications (1)

Publication Number Publication Date
MX2019001132A true MX2019001132A (es) 2019-12-16

Family

ID=59745317

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019001132A MX2019001132A (es) 2016-07-29 2017-07-28 Compuestos de tiazolo-piridina sustituida como inhibidores de malt1.

Country Status (15)

Country Link
US (1) US20190275012A9 (es)
JP (1) JP2019522035A (es)
KR (1) KR20190033607A (es)
CN (1) CN110312724A (es)
AU (1) AU2017302182B2 (es)
CA (1) CA3032334A1 (es)
CL (1) CL2019000221A1 (es)
DO (1) DOP2019000020A (es)
IL (1) IL289474A (es)
MX (1) MX2019001132A (es)
PE (1) PE20190656A1 (es)
PH (1) PH12019500214A1 (es)
RU (1) RU2019104890A (es)
SG (1) SG11201900745VA (es)
WO (1) WO2018020474A1 (es)

Families Citing this family (16)

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EP3592731A4 (en) * 2017-03-08 2020-10-07 Cornell University MALT1 INHIBITORS AND THEIR USES
EP3710441A1 (en) * 2017-11-17 2020-09-23 Hepagene Therapeutics, Inc. Urea derivatives as inhibitors of ask1
US10888550B2 (en) 2018-06-18 2021-01-12 Janssen Pharmaceutica Nv Pyrazole derivatives as MALT1 inhibitors
CN112585128B (zh) 2018-06-18 2023-02-21 詹森药业有限公司 作为malt1抑制剂的吡唑衍生物
CN109265453A (zh) * 2018-10-23 2019-01-25 华侨大学 一种用作caspase-3激活剂的缩氨基脲类衍生物及其应用
EP3888652A4 (en) 2018-11-28 2022-10-19 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
KR20210151880A (ko) 2019-04-11 2021-12-14 얀센 파마슈티카 엔.브이. Malt1 억제제로서의 피리딘 고리 함유 유도체
TW202115077A (zh) * 2019-07-01 2021-04-16 大陸商上海齊魯銳格醫藥研發有限公司 Ｍａｌｔ１抑制劑及其用途
WO2021063735A1 (en) * 2019-10-02 2021-04-08 Basf Se New bicyclic pyridine derivatives
JP2023509886A (ja) * 2019-12-27 2023-03-10 シュレーディンガー， インコーポレイテッド 環式化合物およびその使用方法
JPWO2021241611A1 (es) 2020-05-27 2021-12-02
US20230235077A1 (en) 2020-06-24 2023-07-27 The General Hospital Corporation Materials and methods of treating cancer
WO2022101676A1 (en) * 2020-11-12 2022-05-19 Monopteros Therapeutics,Inc. Materials and methods of treating cancer
WO2023148501A1 (en) 2022-02-03 2023-08-10 C4X Discovery Limited Heterocyclic derivatives as malt1 inhibitors
WO2023192506A1 (en) * 2022-03-31 2023-10-05 Rarified Biosciences, Inc. Malt1 modulators and uses thereof
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑

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US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
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HUP0203160A3 (en) * 1999-11-05 2006-02-28 Warner Lambert Co Prevention of plaque rupture by acat inhibitors
WO2003090746A1 (en) * 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha 1,3-thiazoles as lxr modulators in the treatment of cardiovascular diseases
US9051595B2 (en) 2007-06-01 2015-06-09 University Of Lausanne Malt1 specific cleavage in assay and screening method
ATE553769T1 (de) 2007-11-21 2012-05-15 Vib Vzw Inhibitoren der malt1-proteolytischen aktivität und ihre verwendung
CA2842976A1 (en) * 2011-07-26 2013-01-31 Grunenthal Gmbh Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands
ES2716276T3 (es) * 2011-08-02 2019-06-11 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh Inhibición selectiva de proteasa MALT1 mediante derivados de fenotiazina
WO2013053765A1 (en) 2011-10-11 2013-04-18 Proyecto De Biomedicina Cima, S.L. A non-human animal model of mucosa-associated lymphoid tissue (malt) lymphoma
SG11201503642YA (en) 2012-11-09 2015-06-29 Univ Cornell Small molecule inhibitors of malt1
WO2014086478A1 (en) 2012-12-03 2014-06-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of malt1 protease
EP3013818B1 (en) 2013-06-26 2021-12-29 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (s)-enantiomer of mepazine as paracaspase (malt1) inhibitor for treating cancer
WO2015110406A1 (en) 2014-01-21 2015-07-30 Helmholtz Zentrum München Means and methods for detecting activated malt1
LT3149001T (lt) 2014-05-28 2019-08-12 Novartis Ag Naujieji pirazolo pirimidino dariniai ir jų panaudojimas kaip malt1 inhibitorių
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Also Published As

Publication number Publication date
RU2019104890A3 (es) 2020-08-31
IL289474A (en) 2022-02-01
CN110312724A (zh) 2019-10-08
CA3032334A1 (en) 2018-02-01
WO2018020474A1 (en) 2018-02-01
PH12019500214A1 (en) 2019-10-28
US20190275012A9 (en) 2019-09-12
JP2019522035A (ja) 2019-08-08
AU2017302182A1 (en) 2019-03-07
RU2019104890A (ru) 2020-08-31
CL2019000221A1 (es) 2019-06-07
DOP2019000020A (es) 2019-04-30
SG11201900745VA (en) 2019-02-27
KR20190033607A (ko) 2019-03-29
PE20190656A1 (es) 2019-05-08
US20190160045A1 (en) 2019-05-30
AU2017302182B2 (en) 2021-11-04

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