ES8401486A1 - Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Info

Publication number
ES8401486A1
ES8401486A1 ES517193A ES517193A ES8401486A1 ES 8401486 A1 ES8401486 A1 ES 8401486A1 ES 517193 A ES517193 A ES 517193A ES 517193 A ES517193 A ES 517193A ES 8401486 A1 ES8401486 A1 ES 8401486A1
Authority
ES
Spain
Prior art keywords
4alkyl
group
amino
compounds
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517193A
Other languages
English (en)
Other versions
ES517193A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8401486A1 publication Critical patent/ES8401486A1/es
Publication of ES517193A0 publication Critical patent/ES517193A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZO 4,5-C PIRIDINA, DE FORMULA (I), EN LA QUE N ES 1, 2 O 3; R1 ES HALOGENO, UN GRUPO HIDROXI O UN GRUPO AMINO; R2 REPRESENTA UN GRUPO ALCOHILO DE 1 A 4 ATOMOS DE CARBONO; R3 REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO O UN GRUPO HIDROXI; Y M ES 0 O 1, Y SUS N-OXIDOS Y SUS SALES DE ADICION DE ACIDOS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R3 TIENE EL SIGNIFICADO YA INDICADO; Y X E Y, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS UN GRUPOAMINO, CON UN COMPUESTO DE FORMULA (III), EN LA QUE R1 Y N TIENEN EL SIGNIFICADO YA INDICADO; Y Z REPRESENTA UN GRUPO CAPAZ DE REACCIONAR CON GRUPOS X E Y PARA FORMAR UN SISTEMA DE ANILLO IMIDAZO.DE APLICACION EN EL TRATAMIENTO DE FALLOS CARDIACOS.
ES517193A 1981-11-10 1982-11-08 Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. Granted ES517193A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8133930 1981-11-10
GB8133942 1981-11-10
GB8213846 1982-05-12

Publications (2)

Publication Number Publication Date
ES8401486A1 true ES8401486A1 (es) 1983-12-01
ES517193A0 ES517193A0 (es) 1983-12-01

Family

ID=27261362

Family Applications (2)

Application Number Title Priority Date Filing Date
ES517193A Granted ES517193A0 (es) 1981-11-10 1982-11-08 Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
ES523083A Expired ES8503351A1 (es) 1981-11-10 1983-06-08 Un procedimiento para preparar nuevos derivados de imidazo (4,5-c) piridina (como divisional de la solicitud de patente de invencion num. 517.193, presentada el 8 de noviembre de 1982)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES523083A Expired ES8503351A1 (es) 1981-11-10 1983-06-08 Un procedimiento para preparar nuevos derivados de imidazo (4,5-c) piridina (como divisional de la solicitud de patente de invencion num. 517.193, presentada el 8 de noviembre de 1982)

Country Status (17)

Country Link
US (1) US4603139A (es)
EP (1) EP0079083B1 (es)
KR (1) KR890000022B1 (es)
AR (1) AR241247A1 (es)
AU (1) AU9030682A (es)
DD (1) DD205904A5 (es)
DK (1) DK161325C (es)
ES (2) ES517193A0 (es)
FI (1) FI79312C (es)
GB (1) GB2113675B (es)
GR (1) GR76746B (es)
IE (1) IE56478B1 (es)
IL (1) IL67206A0 (es)
MC (1) MC1491A1 (es)
NO (1) NO158100C (es)
PH (1) PH22764A (es)
PT (1) PT75820B (es)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1295330C (en) * 1985-03-29 1992-02-04 James M. Greene Synthesis of inotropic imidazo(4,5-c) pyridine
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
ZA889365B (en) * 1987-12-22 1990-08-29 Lilly Co Eli Hydrates of andinotropic agent
GB8822170D0 (en) * 1988-09-21 1988-10-26 Pfizer Ltd Therapeutic agents
DE69104481T2 (de) * 1990-05-09 1995-02-09 Pfizer Imidazo[4,5-c]pyridine als paf antagonisten.
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
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EP2987487B1 (en) * 2009-08-10 2020-10-07 Samumed, LLC Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
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WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
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WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
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US10392383B2 (en) 2015-08-03 2019-08-27 Samumed, Llc 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017023984A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023972A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10226448B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
WO2017024015A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10285982B2 (en) 2015-08-03 2019-05-14 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10166218B2 (en) 2015-08-03 2019-01-01 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017023993A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
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CN108472290A (zh) 2015-11-06 2018-08-31 萨穆梅德有限公司 治疗骨关节炎
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Also Published As

Publication number Publication date
GR76746B (es) 1984-08-30
FI79312C (fi) 1989-12-11
IL67206A0 (en) 1983-03-31
EP0079083A1 (en) 1983-05-18
EP0079083B1 (en) 1991-02-27
FI823846A0 (fi) 1982-11-09
NO158100B (no) 1988-04-05
FI79312B (fi) 1989-08-31
DK161325B (da) 1991-06-24
GB2113675A (en) 1983-08-10
ES517193A0 (es) 1983-12-01
AU9030682A (en) 1983-05-19
MC1491A1 (fr) 1983-09-12
DD205904A5 (de) 1984-01-11
DK499582A (da) 1983-05-11
ES523083A0 (es) 1985-02-16
IE822667L (en) 1983-05-10
ES8503351A1 (es) 1985-02-16
DK161325C (da) 1991-12-02
PT75820A (en) 1982-12-01
GB2113675B (en) 1985-10-30
NO823732L (no) 1983-05-11
KR890000022B1 (ko) 1989-03-06
KR840002398A (ko) 1984-07-02
NO158100C (no) 1988-07-13
FI823846L (fi) 1983-05-11
IE56478B1 (en) 1991-08-14
AR241247A1 (es) 1992-03-31
PT75820B (en) 1986-06-11
US4603139A (en) 1986-07-29
PH22764A (en) 1988-12-12

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